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The estimation model of vectorial capacity depend on midgut flora in mosquito.

Research Project

Project/Area Number 22405038
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Applied veterinary science
Research InstitutionObihiro University of Agriculture and Veterinary Medicine

Principal Investigator

FUKUMOTO Shinya  帯広畜産大学, 原虫病研究センター, 准教授 (50376422)

Co-Investigator(Kenkyū-buntansha) KANUKA Hirotaka  東京慈恵会医科大学, 医学部, 教授 (50342770)
KOIKE Masanori  帯広畜産大学, 畜産学部, 教授 (00205303)
Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Keywordsベクター / 腸内細菌 / マラリア / ハマダラカ / ブルキナファソ
Outline of Final Research Achievements

This study aims to investigate the correlation of midgut flora of malaria vector and vectorial capacity in anopheline mosquito of Burukina Faso. We analyzed the vector flora, prevalence in vector, and prevalence in human using Malaria as the study model for vector-borne diseases.
As the result of the survey, it was demonstrated that the phenotypic variation of vector flora correlated to vectorial capacity of the mosquitoes. This finding indicated that artificial flora manipulation strategy to the vector insects is useful for the control of vector-borne diseases.

Report

(5 results)
  • 2014 Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (21 results)

All 2015 2013 2012 2011 2010

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (13 results)

  • [Journal Article] Intra-specific diversity of Serratia marcescens in Anopheles mosquito midgut defines Plasmodium transmission capacity2013

    • Author(s)
      Bando, H. Okado, K. Guelbeogo, W. M. Badolo, A. Aonuma, H. Nelson, B. Fukumoto, S. Xuan, X. Sagnon, N. Kanuka, H.
    • Journal Title

      Sci Rep

      Volume: 3 Issue: 1 Pages: 1641-1641

    • DOI

      10.1038/srep01641

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] In vitro and in vivo antimalarial activities of T-2307, a novel arylamidine.2012

    • Author(s)
      Kimura, A., Nishikawa, H., Nomura, N., Mitsuyama, J., Fukumoto, S., Inoue, N.Kawazu, S.
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 56 Issue: 4 Pages: 2191-3

    • DOI

      10.1128/aac.05856-11

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial peroxidase TPx-2 is not essential in the blood and insect stages of Plasmodium berghei.2012

    • Author(s)
      Masuda-Suganuma, H., Usui, M., Fukumoto, S., Inoue, N.Kawazu, S.
    • Journal Title

      Parasit Vectors

      Volume: 5 Issue: 1 Pages: 252-252

    • DOI

      10.1186/1756-3305-5-252

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calcium signal regulates temperature-dependent transformation of sporozoites in malaria parasite development2011

    • Author(s)
      Doi, Y. Shinzawa, N. Fukumoto, S. Okano, H. Kanuka, H.
    • Journal Title

      Exp Parasitol

      Volume: 128 Issue: 2 Pages: 176-80

    • DOI

      10.1016/j.exppara.2011.02.011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of the observational method for Plasmodium berghei oocysts in the midgut of mosquitoes2011

    • Author(s)
      Usui, M. Fukumoto, S. Inoue, N. Kawazu, S.
    • Journal Title

      Parasit Vectors

      Volume: 4 Issue: 1 Pages: 118-118

    • DOI

      10.1186/1756-3305-4-118

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of proboscis of the malaria vector mosquito Anopheles stephensi in host-seeking behavior2011

    • Author(s)
      Maekawa E, Aonuma H, Nelson B, Yoshimura A, Tokunaga F, Fukumoto S, Kanuka H
    • Journal Title

      Parasit Vectors

      Volume: 4 Pages: 10-10

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A single fluorescence-based LAMP reaction for identifying multiple parasites in mosquitoes2010

    • Author(s)
      Aonuma H, Yoshimura A, Kobayashi T, Okado K, Badolo A, Nelson B, Kanuka H, Fukumoto S
    • Journal Title

      Exp Parasitol

      Volume: 125 Pages: 179-183

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ADF2 is required for transformation of the ookinete and sporozoite in malaria parasite development2010

    • Author(s)
      Doi Y, Shinzawa N, Fukumoto S, Okano H, Kanuka H
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 397 Pages: 668-672

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] フィールド採集ハマダラカからの等温遺伝子増幅法による熱帯熱マラリア原虫検出法の検討2015

    • Author(s)
      曽賀晃、アタナセ バドロ、纐纈摩美、福本晋也
    • Organizer
      第67回日本衛生動物学会
    • Place of Presentation
      金沢大学宝町キャンパス(石川県金沢市)
    • Year and Date
      2015-03-27 – 2015-03-29
    • Related Report
      2013 Annual Research Report
  • [Presentation] LAMP法によるG119S Ace1R変異検出法の開発と西アフリカ-ブルキナファソ採集ガンビアハマダラカでの検証2015

    • Author(s)
      アタナセ バドロ、纐纈摩美、福本晋也
    • Organizer
      第67回日本衛生動物学会
    • Place of Presentation
      金沢大学宝町キャンパス(石川県金沢市)
    • Year and Date
      2015-03-27 – 2015-03-29
    • Related Report
      2013 Annual Research Report
  • [Presentation] Development of LAMP-based method to detect 1014F kdr and 119S ace-1R mutations in field collected Anopheles gambiae s.l.2013

    • Author(s)
      A. Badolo A., Fukumoto S., Okado K., Aonuma H., Guelbeogo W.M., Bando H., Yoshimura A., Sagnon N’F and Kanuka H.
    • Organizer
      6th MIM Pan-African Malaria Conference. "Moving towards malaria elimination: Investing in research and control"
    • Place of Presentation
      The International Convention Centre, Durban, South Africa
    • Year and Date
      2013-10-06 – 2013-10-11
    • Related Report
      2013 Annual Research Report
  • [Presentation] 西アフリカに生息するマラリア媒介蚊の腸内細菌種内多様性に関する研究2013

    • Author(s)
      伴戸寛徳、岡戸清、青沼宏佳、福本晋也、嘉糠洋陸
    • Organizer
      第156回日本獣医学会
    • Place of Presentation
      岐阜大学( 岐阜県岐阜市 )
    • Year and Date
      2013-09-20 – 2013-09-22
    • Related Report
      2013 Annual Research Report
  • [Presentation] Amino acid related host nutrition dynamics during malaria infection.2013

    • Author(s)
      Saiki E, Nagao K, Fukumoto S, Bannai M, Kanuka H
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology : Malaria.
    • Place of Presentation
      JW Marriott New Orleans, New Orleans, Louisiana USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] 非共生細菌の表現型揺らぎが規定するベクター・寄生虫間相互作用2013

    • Author(s)
      嘉糠洋陸、伴戸寛徳、岡戸清、Guelbego Wamdaogo、Badolo Athanase、青沼宏佳、福本晋也、NFale Sagnon
    • Organizer
      第82回日本寄生虫学会
    • Place of Presentation
      東京医科歯科大学( 東京都文京区 )
    • Related Report
      2012 Annual Research Report
  • [Presentation] マラリア原虫感染時の宿主血中アミノ酸インフォマティクス2013

    • Author(s)
      齋木選射、長尾健児、福本晋也、坂内慎、嘉糠洋陸
    • Organizer
      第82回日本寄生虫学会
    • Place of Presentation
      東京医科歯科大学( 東京都文京区 )
    • Related Report
      2012 Annual Research Report
  • [Presentation] 長残光性蓄光材のAnopheles stephensi に対する誘引性の評価2013

    • Author(s)
      竹下準也,石井嶺広,小池正徳,福本晋也,嘉糠洋陸,相内大吾
    • Organizer
      第57回日本応用動物昆虫学会大会
    • Place of Presentation
      日本大学( 神奈川藤沢市 )
    • Related Report
      2012 Annual Research Report
  • [Presentation] Amino acid related host nutrition dynamics during malaria infection.2012

    • Author(s)
      Saiki E, Nagao K, Fukumoto S, Bannai M, Kanuka H.
    • Organizer
      第14回日韓寄生虫学セミナー
    • Place of Presentation
      青島パームビーチホテル( 宮崎県宮崎市 )
    • Related Report
      2012 Annual Research Report
  • [Presentation] 野生蚊の虫体および虫体内から分離された昆虫寄生性アナモルフ菌類のAnopheles stephensi雌成虫に対する致死性・感染性の比較2012

    • Author(s)
      石井嶺広 、竹下準也, 石山海嗣, 小池正徳, 嘉糠洋陸, 福本晋也, 相内大吾
    • Organizer
      第56回日本応用動物昆虫学会大会
    • Place of Presentation
      奈良県
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腸内細菌の“ゆらぎ”が宿主-病原体相互作用に与える影響2011

    • Author(s)
      伴戸寛徳、岡戸清、Moussa Guelbeogo、Athanase Badolo、青沼宏佳、福本晋也、N’Fale Sagnon、嘉糠洋陸
    • Organizer
      第34 回日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] Impact of intra-specific diversity of mosquito midgut bacteria on Plasmodium development2011

    • Author(s)
      Hironori Bando, Kiyoshi Okado, Moussa Guelbeogo, Athanase Badolo, Hiroka Aonuma, Shinya Fukumoto, N’Fale Sagnon, and Hirotaka Kanuka
    • Organizer
      第80回米国熱帯医学会
    • Place of Presentation
      フィラデルフィア
    • Related Report
      2011 Annual Research Report
  • [Presentation] 宿主-病原体相互作用における腸管内細菌のゆらぎ2010

    • Author(s)
      宿主-病原体相互作用
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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