Clinical application of diagnosis method of bovine major histocompatibility complex genes associated with resistanceand susceptibility to bovine leukemia virus-induced lymphomain East Asia

• Project/Area Number: 22405040
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Applied veterinary science
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: AIDA Yoko 独立行政法人理化学研究所, 分子ウイルス学特別研究ユニット, ユニットリーダー (50182994)
• Co-Investigator(Renkei-kenkyūsha): ONUMA Misao 北海道大学, (連合)獣医学研究科, 名誉教授 (70109510)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2012: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2010: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
• Keywords: BoLA クラスIIDRB3 / PCR-Sequence based typing(SBT)法 / BLV,BLV nested PCR / フィリピン / ホルスタイン / ブラーマン / Native cattle / BoLAクラスIIDRB3 / PCR-SBT法 / 新規・既知アリル / 東南アジア / 固有品種 / 交雑種 / 多型性 / BoLAクラスII DRB3・DQA1 / BLV nested PCR / 中国山東省

Research Abstract

We previously demonstrated that bovine leukocyte antigens (BoLA)-DRB3 alleles associated with resistance or susceptibility to development of bovine leukemia virus (BLV)-induced B lymphoma and analyzed distribution of these alleles in Japan and South-America. However, until now, none of the South-east Asian breed had been characterized for BoLA-DRB3 genes by PCR-sequence based typing (SBT). Hence, we here sequenced exon 2 of the BoLA class II DRB3 gene from 981 cattle including Holstein, Sahiwal, Brahman, Philippine Native and its cross breed, corrected from five islands of Philippine using modified SBT method which is suitable for Philippine cattle. In addition, we detected BLV by a new BLV-CoCoMo-qPCR. We identified the 75 previously reported alleles and 6 novel alleles. Interestingly, the number found in each breed is extent high level, indicating that that Asian breeds reveal extent high level of polymorphism for BoLA-DRB3 distributions. Our result also showed BLV-infected cattle with the susceptibility-associated allele was significantly lower than that in Japan.

Research Products

• [Journal Article] Characterization of bovine MHC class II DRB3 diversity in Latin America Creole cattle breeds (2013)
  • Author(s): Giovambattista G., Takeshima S-n., Veronica M.R., Matsumoto Y, Angela A. Franco, Saito H., Onuma M., and Aida Y
  • Journal Title: Gene Volume: 519 Pages: 150-158
  • Peer Reviewed
• [Journal Article] Identification of bovine leukemia virus proviral load in Japanese Black cattle (2013)
  • Author(s): Miyasaka T. , Takeshima S-n. , Jimba M. , Kobayashi N. , Matsuhashi T. , Matsumoto Y. , Sentsui H. and Aida Y
  • Journal Title: Tissue Antigens Volume: 81 Pages: 72-82
  • Peer Reviewed
• [Journal Article] 兵庫県中部でみられたホルスタイン種における牛白血病の病態及び発症要因の検討 (2013)
  • Author(s): 富田啓介, 中条正樹,加茂前優花,矢島和枝,浦本京也,竹嶋伸之輔,間 陽子
  • Journal Title: 日本獣医師会雑誌 Volume: 2、66 Pages: 109-114
  • NAID: 10031168955
  • Peer Reviewed
• [Journal Article] Ohashi K., Enhanced expression of LAG-3 on lymphocyte subpopulations from persistently lymphocytotic cattle infected with bovine leukemia virus (2013)
  • Author(s): Konnai, S., Suzuki, S., Shirai, T., Ikebuchi, R., Okagawa, T., Sunden., Y, Mingala C.N., Onuma, M., Murata, S
  • Journal Title: Comp. Immunol. Microbiol. Infect. Dis Volume: 36 Pages: 63-69
  • Peer Reviewed
• [Journal Article] Importin α/Qip1 Is Involved in Multiplication of Mutant Influenza Virus with Alanine Mutation at Amino Acid 9 Independently of Nuclear Tranport Function (2013)
  • Author(s): Sasaki Y. , Hagiwara K. , Kakisaka M. , Yamada K. , Murakami T. , Aida Y.
  • Journal Title: PLoS ONE Volume: 8-1
  • Peer Reviewed
• [Journal Article] Characterization of Meq proteins from field isolates of Marek’s disease virus in Japan. (2013)
  • Author(s): Murata, S., Hashiguchi T., Hayashi, Y., Yamamoto Y., Matsuyama-Kato A., Takasaki S., Isezaki M., Onuma M., Konnai S., Ohashi K.
  • Journal Title: Infect. Genet. Evol. Volume: -
  • NAID: 120005317003
  • Peer Reviewed
• [Journal Article] Isolation, cloning and pathologic analysis of Trypanosoma evansi field isolates (2013)
  • Author(s): Mekata H., Konnai S., Mingala C.N., Abes N.S., Gutierrez A., Dargantes A.P., Witola W.H., Inoue N., Onuma M., Murata S., Ohash K.
  • Journal Title: Parasitol. Res. Volume: -
  • Peer Reviewed
• [Journal Article] Enhanced expression of LAG-3 on lymphocyte subpopulations from persistently lymphocytotic cattle infected with bovine leukemia virus (2013)
  • Author(s): Konnai S., Suzuki S., Shirai T., Ikebuchi R., Okagawa T., Sunden Y, Mingala C.N., Onuma M., Murata S., Ohashi K.
  • Journal Title: Comp. Immunol. Microbiol. Infect. Dis Volume: 36 Pages: 63-69
  • Peer Reviewed
• [Journal Article] BLV-CoCoMo-qPCR: a useful tool for evaluating bovine leukemia virus infection status (2012)
  • Author(s): Jimba M, Takeshima S-n, Kohara J, Kobayashi N, Matsuhashi T, Omori T, Nunoya T and Aida Y
  • Journal Title: BMC Vet Res Volume: 8 Pages: 167-167
  • Peer Reviewed
• [Journal Article] The pH-sensitive fusogenic3-methyl-glutarylated hyperbranched oly(glycidol) (MGlu-HPG)-conjugated liposome induces antigen-specific cellular and humoral immunity (2012)
  • Author(s): Hebishima T, Yuba E, Kono K, Takeshima S-n, Ito Y and Aida Y
  • Journal Title: Clin. Vaccine Immunol Volume: 19 Pages: 1492-1498
  • Peer Reviewed
• [Journal Article] Association between BoLA-DRB3 and somatic cell count in Holstein cattle from Argentina (2012)
  • Author(s): Baltian L. , Ripoli M. , Sanfilippo S. , Takeshima S-n., Aida Y., Giovambattista G
  • Journal Title: Molecular Biology Reports
  • Peer Reviewed
• [Journal Article] Visualizing spatiotemporal dynamics of apoptosis after G1 arrest by human T cell leukemia virus type 1 Tax and insights into gene expression changes using microarraybased gene expression analysis (2012)
  • Author(s): Arainga M., Murakami H., Aida Y
  • Journal Title: BMC Genomics Volume: 13 Pages: 275-275
  • Peer Reviewed
• [Journal Article] Identification of bovine leukemia virus Tax function associated with host cell transcription, signaling, stress response and immune response pathway by microarray-based gene expression analysis (2012)
  • Author(s): Arainga M., Takeda E., Aida Y
  • Journal Title: BMC Genomics Volume: 13 Pages: 121-121
  • Peer Reviewed
• [Journal Article] Effects of interferon tau on cattle persistently infected with bovine viral diarrhea virus (2012)
  • Author(s): Kohara, J., Nishikura, Y., Konnai, S., Tajima, M., Onuma, M
  • Journal Title: Jpn. J. Vet. Res Volume: 60 Pages: 63-70
  • Peer Reviewed
• [Journal Article] Increased bovine Tim-3 and its ligand expressions during bovine leukemia virus infection (2012)
  • Author(s): Okagawa, T., Konnai, S., Ikebuchi, R., Suzuki, S., Shirai, T., Sunden, Y., Onuma M., Murata, S., Ohashi, K
  • Journal Title: Vet. Res Volume: 43 Pages: 45-45
  • Peer Reviewed
• [Journal Article] BLV-CoCoMo-qPCR: a useful tool for evaluating bovine leukemia virus infection status (2012)
  • Author(s): Jimba M., Takeshima S-n., Kohara J., Kobayashi N., Matsuhashi T., Omori T., Nunoya T., Aida Y.
  • Journal Title: BMC Vet. Res Volume: 8 Pages: 167-167
  • Peer Reviewed
• [Journal Article] Association between BoLA-DRB3 and somatic cell count in Holstein cattle from Argentina (2012)
  • Author(s): Baltian L. , Ripoli M. , Sanfilippo S. , Takeshima S-n., Aida Y.,Giovambattista G.
  • Journal Title: Molecular Biology Reports Volume: -
  • Peer Reviewed
• [Journal Article] The pH-sensitive fusogenic3-methyl-glutarylated hyperbranched poly(glycidol) (MGlu-HPG)-conjugated liposome induces antigen-specific cellular and (2012)
  • Author(s): Hebishima T., Yuba E., Kono K., Takeshima S-n., Ito Y., Aida Y.
  • Journal Title: Clin. Vaccine Immunol. Volume: 19 Pages: 1492-1498
  • Peer Reviewed
• [Journal Article] Identification of a novel compound with anitiviral activity against influenza A virus depending on PA subunit of viral RNA polymerase (2012)
  • Author(s): Yamada K. , Koyama H., Hagiwara K., Ueda A. , Sasaki Y. , Kanesashi S-n. , Ueno R. , Nakamura H. , Kuwata K. , Shimizu K. , Suzuki M. , Aida Y.
  • Journal Title: Microbes and Infection Volume: 14 Pages: 740-747
  • Peer Reviewed
• [Journal Article] The 5’Flanking Reagion and Intron1 of the Bovine Prion Protein Gene(PRNP)Are Responsible for Negative Feedback Regulation of the Prion Protein (2012)
  • Author(s): Xue G. , Aida Y. , Onodera T. , Sakudo A.
  • Journal Title: PLoS ONE Volume: 7, e32870 Pages: 1-7
  • Peer Reviewed
• [Journal Article] Visualizing spatiotemporal dynamics of apoptosis after G1 arrest by human T cell leukemia virus type 1 Tax and insights into gene expression changes using microarray- (2012)
  • Author(s): Arainga M., Murakami H., Aida Y.
  • Journal Title: BMC Genomics Volume: 13 Pages: 275-275
  • Peer Reviewed
• [Journal Article] Identification of bovine leukemia virus Tax function associated with host cell transcription, signaling, stress response and immune response pathway by microarray-based gene expression analysis (2012)
  • Author(s): Arainga M., Takeda E., Aida Y.
  • Journal Title: BMC Genomics Volume: 13 Pages: 121-121
  • Peer Reviewed
• [Journal Article] Effects of interferon tau on cattle persistently infected with bovine viral diarrhea virus (2012)
  • Author(s): Kohara J., Nishikura Y., Konnai S., Tajima M., Onuma M.
  • Journal Title: Jpn. J. Vet. Res. Volume: 60 Pages: 63-70
  • Peer Reviewed
• [Journal Article] Increased bovine Tim-3 and its ligand expressions during bovine leukemia virus infection. (2012)
  • Author(s): Okagawa T., Konnai S., Ikebuchi R., Suzuki S., Shirai T., Sunden Y., Onuma M., Murata S., Ohashi K.
  • Journal Title: Vet. Res Volume: 43 Pages: 45-45
  • Peer Reviewed
• [Journal Article] Kinetics of regulatory dendritic cells in inflammatory responses during Trypanosoma evansi infection (2012)
  • Author(s): Mekata H., Konnai S., Mingala C.N., Abes N.S., Gutierrez A., Dargantes A.P., Witola W.H., Inoue N., Onuma M., Murata S., Ohash K.
  • Journal Title: Parasite Immunol. Volume: 34 Pages: 318-329
  • Peer Reviewed
• [Journal Article] Association between BoLA-DRB3 and somatic cell score in Holstein cattle from Argentina (2012)
  • Author(s): Baltian LR, Ripoli MV, Sanfilippo S, Takeshima S-N, Aida Y, Giovambattista G
  • Journal Title: Molecular Biology Reports Volume: (in press)
  • Peer Reviewed
• [Journal Article] Identification of bovine leukemia virus Tax function associated with Host cell transcription, signaling, stress response and immune Response pathway by Microarray-based gene exoression analysis (2012)
  • Author(s): Mariluz Arainga-Ramirez, Eri Takeda, Yoko Aida
  • Journal Title: BMC Genomics Volume: (in press)
  • Peer Reviewed
• [Journal Article] Visualizing spatiotemporal dynamics of apoptosis after G1 arrest by human T cell leukemia virus type 1 Tax and insights into gene expression changes using microarray-based gene expression analysis (2012)
  • Author(s): Mariluz Arainga-Ramirez, Hironobu Murakami, Yoko Aida
  • Journal Title: BMC Genomics Volume: (in press)
  • Peer Reviewed
• [Journal Article] ホルスタイン種における牛白血病の病態及び発症要因の検討 (2012)
  • Author(s): 富田啓介, 中条正樹, 加茂前優花, 塚本洋, 柴折浩幸, 岡畑一幸, 矢島和枝, 浦本京也, 竹嶋伸之輔, 間陽子
  • Journal Title: 日本獣医師会雑誌 Volume: (in press)
  • Peer Reviewed
• [Journal Article] The 5' flanking region and intronl of the bovine prion protein gene (PRNP) are responsible for negative feedback regulation of the prion protein (2012)
  • Author(s): Guangai Xue, Yoko Aida, Takashi Onodera, Akikazu Sakudo
  • Journal Title: PLoS ONE Volume: (in press)
  • Peer Reviewed
• [Journal Article] pH-sensitive fusogenic3-methyl-glutarylated hyperbranchedpoly(glycidol) (MGlu-HPG)- onjugatedliposome induces antigen-specificcellular and humoral immunity (2011)
  • Author(s): Hebishima T, Yuba E, Kono K, Takeshima S-n,Ito Y and Aida Y
  • Journal Title: Clin. Vaccine Immunol
  • Peer Reviewed
• [Journal Article] Imaging and microarray analyses of cell cycle arrest and apoptosis by Human T cell Leukemia Virus type 1 (HTLV-1) Tax (2011)
  • Author(s): Arainga M., Aida Y
  • Volume: A175
  • Peer Reviewed
• [Journal Article] Regulation of host cellular gene transcription by Bovine Leukemia Virus (BLV) Tax, wild type and mutants (2011)
  • Author(s): Arainga M., Takeda E., Aida Y
  • Journal Title: Retovirology Volume: 8
  • Peer Reviewed
• [Journal Article] BLV-CoCoMo-qPCR: comparison of other detection methods for BLV infection and kinetics analysis in experimental transmission of BLV in cattle (2011)
  • Author(s): Jimba M., Takeshima S-n., Matsumoto Y., Kobayashi N., Matsuhashi T., Kohara J., Aida Y
  • Journal Title: Retovirology Volume: A21
  • Peer Reviewed
• [Journal Article] Bovine MHC class II molecule plays a key role in bovine leukemia virus (BLV)-induced lymophoma (2011)
  • Author(s): Aida Y., Takeshima S-n., Matsumoto Y., Miyasaka T., Miyazaki Y., Tanabe Y., W. C. Davis, Okada K.
  • Journal Title: Retovirology Volume: A7
  • Peer Reviewed
• [Journal Article] Induction of antigen-specific cellular and humoral immunity by pH-sensitive carbonate apatite (2011)
  • Author(s): Hebishima T, Tada S., Takeshima S-n, Akaike T, Ito Y, Aida Y
  • Journal Title: revised in Biochem. Biophys. Res. Commun Volume: 415 Pages: 597-601
  • Peer Reviewed
• [Journal Article] Indentification and bovine majot histocompatibility complex class II haplotypes in JapaneseBlack and Holstein cattle in Japan (2011)
  • Author(s): Miyasaka T., Takeshima S-n., Matsumoto Y., Kobayashi N., Matsuhashi T.,Miyazaki Y., Tanabe Y., Ishibashi K., Sentsui S., and Aida Y
  • Journal Title: J. Dairy Sci Volume: 95 Pages: 420-31
  • Peer Reviewed
• [Journal Article] A New Method for Typing Bovine Major Histocompatibility Complex Class II DRB3 Alleles by Combining Two Established PCR Sequence-Based (2011)
  • Author(s): Takeshima S-n., Matsumoto Y, Miyasaka T, Arainga M., Saito H., Onuma M. and Aida Y
  • Journal Title: Techniques, Tissue Antigens Volume: 78 Pages: 208-213
  • Peer Reviewed
• [Journal Article] Increase of cells expressing PD-L1 in bovine leukemia virus infection and enhancement of anti-viral immune responses in vitro via PD-L1 blockade (2011)
  • Author(s): Ikebuchi, R., Konnai, S., Shirai, T., Sunden, Y., Murata, S., Onuma M., Ohashi, K
  • Journal Title: Vet. Res Volume: 42 Pages: 103-103
  • Peer Reviewed
• [Journal Article] Molecular cloning of bovine lymphocyte activation gene-3 and its expression characteristics in bovine leukemia virus-infected cattle. Vet. Immunol (2011)
  • Author(s): Shirai, T., Konnai, S., Ikebuchi, R., Okagawa, T., Suzuki, S., Sunden, Y., Onuma, M., Murata, S., Ohashi, K
  • Journal Title: Immunopathol Volume: 44 Pages: 462-467
  • Peer Reviewed
• [Journal Article] A New Method for Typing Bovine Major Histocompatibility Complex Class II DRB3 Alleles by Combining Two Established PCR Sequence-Based Techniques (2011)
  • Author(s): Shin-nosuke Takeshima, Yuki Matsumoto, Taku Miyasaka, Arainga Ramirez, Maliruz Anamelva, Hideki Saito, Misao Onuma, Yoko Aida
  • Journal Title: Tissue Antigens Volume: 78 Pages: 208-213
  • Peer Reviewed
• [Journal Article] The diversity of bovine MHC class II DRB3 and DQA1 alleles in different herds of Japanese Black and Holstein cattle in Japan (2011)
  • Author(s): Taku Miyasaka, Shin-nosuke Takeshima, Yuki Matusmoto, Naohiko Kobayashi, Tamako Matsuhashi, Yoshiyuki Miyazaki, Yoshihiro Tanabe, Kazuki Ishibashi, Hiroshi Sentsui, Yoko Aida
  • Journal Title: Gene Volume: 472 Pages: 42-49
  • Peer Reviewed
• [Journal Article] Indentification and bovine majot histocompatibility complex class II haplotypes in Japanese Black and Hlstein cattle in Japan (2011)
  • Author(s): Taku Miyasaka, Shin-nosuke Takeshima, Hiroshi Sentsui, Yoko Aida
  • Journal Title: J.Dairy Sci. Volume: 95 Pages: 420-431
  • Peer Reviewed
• [Journal Article] Induction of antigen-specific cellular and humoral immunity by pH-sensitive carbonate apatite (2011)
  • Author(s): Takehisa Hebishima, Seiichi Tada, Shin-nosuke Takeshima, Toshihiro Akaike, Yoshihiro Ito, Yoko Aida
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 415 Pages: 597-601
  • Peer Reviewed
• [Journal Article] Bovine MHC class II molecule plays a key role in bovine leukemia virus (BLV)-induced lymophoma (2011)
  • Author(s): Yoko Aida, Shin-nosuke Takeshima, Yuki Matsumoto, Taku Miyasaka, Yoshiyuki Miyazaki, Yoshiro Tanabe, William C.Davis, Kosuke Okada
  • Journal Title: Retovirology Volume: 8
  • Peer Reviewed
• [Journal Article] BLV-CoCoMo-qPCR : comparison of other detection methods for BLV infection and kinetics analysis in experimental transmission of BLV in cattle (2011)
  • Author(s): Mayuko Jimba, Shin-nosuke Takeshima, Yuki Matsumoto, Naohiko Kobayashi, Tamako Matsuhashi, Junko Kohara, Yoko Aida
  • Journal Title: Retovirology Volume: 8
  • Peer Reviewed
• [Journal Article] Regulation of host cellular gene transcription by Bovine Leukemia Virus (BLV) Tax, wild type and mutants (2011)
  • Author(s): Mariluz Arainga-Ramirez, Eri Takeda, Yoko Aida
  • Journal Title: Retovirology Volume: 8
  • Peer Reviewed
• [Journal Article] 牛白血病ワクチンの開発と新しい疾病防御戦略 (2011)
  • Author(s): 間陽子、竹嶋伸之輔
  • Journal Title: 臨床獣医 Volume: 29 Pages: 23-29
  • Peer Reviewed
• [Journal Article] 牛白血病の世界における感染拡大の現状と防御対策 (2011)
  • Author(s): 間陽子、竹嶋伸之輔
  • Journal Title: Journal of Veterinary Medicine Volume: 64(2) Pages: 115-120
• [Journal Article] The diversity of bovine MHC class II DRB3 and DQA1 alleles in different herds of Japanese Black and Holstein cattle in Japan (2010)
  • Author(s): Miyasaka T., Takeshima S-n., Matsumoto Y., Kobayashi N., Matsuhashi T.,Miyazaki Y., Tanabe Y., Ishibashi K., Sentsui S., and Aida Y
  • Journal Title: Gene Volume: 472 Pages: 42-49
  • Peer Reviewed
• [Journal Article] BLV-CoCoMo-qPCR: Quantitation of bovine leukemia virus proviral load using the CoCoMo algorithm (2010)
  • Author(s): Jimba M., Takeshima S-n, Matoba K., Daiji Endoh D., Aida Y
  • Journal Title: Retroviology Volume: 7 Pages: 91-91
  • NAID: 120005761598
  • Peer Reviewed
• [Journal Article] BLV-CoCoMo-qPCR : Quantitation of bovine leukemia virus proviral load using the CoCoMo algorithm (2010)
  • Author(s): Mayuko Jimba, Shin-nosuke Takeshima, Kazuhiro Matoba, Daiji Endoh, Yoko Aida
  • Journal Title: Retorovirology Volume: 7 Pages: 91-110
  • NAID: 120005761598
  • Peer Reviewed
• [Journal Article] The diversity of bovine MHC class II DRB3 and DQA1 alleles in different Herds of Japanese Black and Holstein cattle in Japan (2010)
  • Author(s): Taku Miyasaka, Shin-nosuke Takeshima, Yuki Matsumoto, Naohiko Kobayashi, Tamako Matsuhashi, Yoshiyuki Miyazaki, Yoshihiro Tanabe, Kazuki Ishibashi, Hiroshi Sentsui, Yoko Aida
  • Journal Title: Gene Volume: 472 Pages: 42-49
  • Peer Reviewed
• [Presentation] 地方病性牛白血病の宿主発症要因の一考察 (2013)
  • Author(s): 斉藤 恵津子、間 陽子、竹嶋 伸之輔、松本 有生
  • Organizer: 平成24年度食肉衛生技術研修会・食肉衛生発表会
  • Place of Presentation: 東京
• [Presentation] インシリコ牛白血病ナノワクチンの開発 (2012)
  • Author(s): 間 陽子
  • Organizer: ナノバイオテクノロジーに基づくDDS 技術による新世代ワクチン技術
  • Place of Presentation: 東京
  • Year and Date: 2012-12-18
• [Presentation] BLV 発症感受性を標的にしたワクチン開発 (2012)
  • Author(s): 竹嶋伸之輔
  • Organizer: シンポジウム牛白血病の新しい制圧戦略平成23 年度日本獣医師会獣医学術年次大会
  • Place of Presentation: 札幌
  • Year and Date: 2012-02-05
• [Presentation] BLV 発症を制御するMHC 遺伝子と新たなる疾病対策 (2012)
  • Author(s): 間陽子
  • Organizer: シンポジウム牛白血病の新しい制圧戦略平成23 年度日本獣医師会獣医学術年次大会
  • Place of Presentation: 札幌
  • Year and Date: 2012-02-05
• [Presentation] BLV発症を制御するMHC遺伝子と新たなる疾病対策 (2012)
  • Author(s): 間陽子
  • Organizer: シンポジウム牛白血病の新しい制圧戦略平成23年度日本獣医師会獣医学術年次大会
  • Place of Presentation: 札幌コンベンションホール(札幌市)(招待講演)
  • Year and Date: 2012-02-05
• [Presentation] 南米大陸におけるウシMHC クラスIIDRB3 遺伝子の頻度調査 (2012)
  • Author(s): 竹嶋 伸之輔、松本 有生、金 智潤、宮坂 卓、Valdivia G., Guillermo G.、 小沼 操、間陽子
  • Organizer: 日本動物遺伝育種学会第13回大会
  • Place of Presentation: 仙台
• [Presentation] フィリピン固有品種におけるウシMHC クラスII DRB3 およびミトコンドリアDNA D-loop 領域の解析 (2012)
  • Author(s): 竹嶋 伸之輔、大橋 未来、宮坂 卓、松本有生、Mingala Claro、小沼 操、間 陽子
  • Organizer: 第21回日本組織適合性学会大会
  • Place of Presentation: 東京
• [Presentation] 牛白血病ウイルス(BLV)プロウイルスロードとBoLA クラスII 遺伝子多型相関性の解析 (2012)
  • Author(s): 宮坂 卓 、竹嶋 伸之輔 、松本 有生、神馬 繭子、小林 直彦、 松橋 珠子、 泉對博 、間 陽子
  • Organizer: 第21回日本組織適合性学会大会
  • Place of Presentation: 東京
• [Presentation] Identification of bovine leukocyte antigen (BoLA) class II haprotypes that are regulated bovine leukemia virus (BLV) proviral load in Japanese Black cattle (2012)
  • Author(s): Aida Y., Miyasaka T., Jimba M., Matsumoto Y., Kobayashi N., Matsuhashi T., Sentsui H.,Takeshima S-n.
  • Organizer: 33rd Conference of the International Society for Animal Genetics
  • Place of Presentation: Cairns, Australia
• [Presentation] Novel Th epitope of bovine leukemia virus detected in disease susceptibility cattle determined by BoLA-DRB3 allele (2012)
  • Author(s): Takeshima S-n., Kim,J.,Kyoj H., Matsumoto Y., Ohmori T., Nunoya T., Matoba K., Aida Y.
  • Organizer: 33rd Conference of the International Society for Animal Genetics
  • Place of Presentation: Cairns, Australia.
• [Presentation] インシリコ牛白血病ナノワクチンの開発 (2012)
  • Author(s): 間陽子
  • Organizer: ナノバイオテクノロジーに基づくDDS技術による新世代ワクチン技術
  • Place of Presentation: 東京大学
  • Invited
• [Presentation] Identification of BLV Tax Function Associated with Host Cell Transcription, Signaling, Stress Response and Immune Response Pathway by Microarray (2012)
  • Author(s): Yoko Aida, Mariluz Arainga
  • Organizer: 24th Workshop on Retroviral Pathogenesis
  • Place of Presentation: アメリカ
• [Presentation] 南米大陸におけるウシMHCクラスIIDRB3遺伝子の頻度調査 (2012)
  • Author(s): 竹嶋 伸之輔、松本 有生、金 智潤、宮坂 卓、Valdivia Gabriela Guillermo Giovambattista、 小沼 操、間 陽子
  • Organizer: 日本動物遺伝育種学会第13回大会
  • Place of Presentation: 東北大学
• [Presentation] i n silico およびナノ粒子を用いた新しい牛白血病ワクチン開発動物用ワクチン (2012)
  • Author(s): 竹嶋 伸之輔、金 智潤、蛇島 武久、萩原 恭二、松本 有生、多田 誠一、Pallavi Ananda、 伊藤 嘉浩、沖本 憲明、山岸 純也、弓場 英司、河野 健司、大森 崇司、布谷 鉄夫、的場 和弘、間 陽子
  • Organizer: バイオ医薬品研究会学術集会
  • Place of Presentation: 岩手大学
  • Invited
• [Presentation] 牛白血病ウイルス感染牛における乳汁中ウイルス遺伝子の検出 (2012)
  • Author(s): 小原 潤子、櫻井 由絵、松本 有生、竹嶋 伸之輔、間 陽子
  • Organizer: 第154回日本獣医学会学術集会
  • Place of Presentation: 岩手大学
• [Presentation] Haplotype determination of upstream regulatory region and the second exon of bovine DRB3 gene (2012)
  • Author(s): Guillermo Giovambattista、 Ripoli Maria、竹嶋 伸之輔、Laura Baltian、間 陽子
  • Organizer: 第21回日本組織適合性学会大会
  • Place of Presentation: 明治大学
• [Presentation] インシリコ手法によるウシMHCクラスII分子を標的とする抗BLV高親和性ペプチドワクチンの設計 (2012)
  • Author(s): 山岸 純也、沖本 憲明、竹嶋 伸之輔、金 智潤、萩原 恭二、間 陽子、泰地 真弘人
  • Organizer: 第21回日本組織適合性学会大会
  • Place of Presentation: 明治大学
• [Presentation] 新規ウシ主要組織適合抗原(MHC)クラスII遺伝子ハプロタイプの同定とその分布 (2012)
  • Author(s): 宮坂 卓、竹嶋 伸之輔、泉對 博、間 陽子
  • Organizer: 第21回日本組織適合性学会大会
  • Place of Presentation: 明治大学
• [Presentation] フィリピン固有品種におけるウシMHCクラスII DRB3およびミトコンドリアDNA D-loop領域の解析 (2012)
  • Author(s): 竹嶋 伸之輔、大橋 未来、宮坂 卓、松本 有生、Mingala Claro、小沼 操、間 陽子
  • Organizer: 第21回日本組織適合性学会大会
  • Place of Presentation: 明治大学
• [Presentation] ウシレトロウイルスによる白血病発症を規定する感受性MHCアリルに対するGagおよびEnv由来ペプチドのエピトープマッピング (2012)
  • Author(s): 竹嶋 伸之輔、的場 和弘、萩原 恭二、金 智潤、山岸 純也、Davis William、大森 崇司、 布谷 鉄夫、沖本 憲明、間 陽子
  • Organizer: 第21回日本組織適合性学会大会
  • Place of Presentation: 明治大学
• [Presentation] 発症感受性アリル情報に基づく牛白血病ワクチンの開発 (2012)
  • Author(s): 間陽子
  • Organizer: 第21回日本組織適合性学会大会
  • Place of Presentation: 明治大学
  • Invited
• [Presentation] 牛白血病ウイルス（ＢＬＶ）プロウイルスロードとBoLAクラスII遺伝子多型相関性の解析 (2012)
  • Author(s): 宮坂 卓 、竹嶋 伸之輔 、松本 有生、 神馬 繭子、小林 直彦、 松橋 珠子、 泉對 博 、間 陽子
  • Organizer: 第21回日本組織適合性学会大会
  • Place of Presentation: 明治大学
• [Presentation] Association of bovine leukemia virus (BLV) Tax function and various host responses by gene expression microarray (2012)
  • Author(s): Yoko Aida, Mariluz Arainga, Eri Takeda, Kazunori Yamada, Mayuko Jimba, Shin-nosuke Takeshima
  • Organizer: 33rd Conference of the International Society for Animal Genetics
  • Place of Presentation: オーストラリア
• [Presentation] Identification of bovine leukocyte antigen (BoLA) class II haprotypes that are regulated bovine leukemia virus (BLV) proviral load in Japanese Black cattle (2012)
  • Author(s): Yoko Aida, Taku Miyasaka, Mayuko Jimba, Yuki Matsumoto, Naohiko Kobayashi, Tamako Matsuhashi, Hiroshi Sentsui and Shin-nosuke Takeshima
  • Organizer: 33rd Conference of the International Society for Animal Genetics
  • Place of Presentation: オーストラリア
• [Presentation] Novel Th epitope of bovine leukemia virus detected in disease susceptibility cattle determined by BoLA-DRB3 allele (2012)
  • Author(s): Shin-nosuke Takeshima, Jiyun Kim, Kyoji Hagiwara, Yuki Matsumoto, Takashi Ohmori, Tetsuo Nunoya, Kazuhiro Matoba, and Yoko Aida
  • Organizer: 33rd Conference of the International Society for Animal Genetics
  • Place of Presentation: オーストラリア
• [Presentation] Nuclear Import process as potential antiviral target for flu and AIDS (2012)
  • Author(s): 間陽子
  • Organizer: Loveland/Jans Lab Seminar
  • Place of Presentation: オーストラリア
  • Invited
• [Presentation] Synthesis of positively and negatively charged cholesterol-recombinant human gelatins for the cellular uptake of proteins and immune reactions (2012)
  • Author(s): Kadengodlu Ananda、蛇島 武久、竹嶋 伸之輔、伊藤 美香、ＬＩＵ ＭＩＮＧＺＨＥ、阿部 洋、 間 陽子、Aigaki Toshiro、伊藤 嘉浩
  • Organizer: 第21回日本組織適合性学会大会
  • Place of Presentation: 明治大学
• [Presentation] HIV-1 Vprによる細胞周期G2期停止に関与する宿主因子のハイスループットスクリーニング法の確立 (2012)
  • Author(s): 村上知行、間陽子
  • Organizer: 第26回日本エイズ学会学術集会・総会
  • Place of Presentation: 慶応大学
• [Presentation] HIV Vprによる細胞周期G2期停止に関与する新規宿主因子の同定 (2012)
  • Author(s): 村上知行、間陽子
  • Organizer: 第60回日本ウイルス学会学術集会
  • Place of Presentation: グランキューブ大阪
• [Presentation] FucciおよびSCAT3.1を用いたHIV-1 Vprによる細胞周期停止とアポトーシス誘導のライブイメージング (2012)
  • Author(s): 村上知行、間陽子
  • Organizer: 第60回日本ウイルス学会学術集会
  • Place of Presentation: グランキューブ大阪
• [Presentation] インポーチンα３/Qip1とヌクレオプロテイン（NP）の結合を介した核移行非依存的なA型インフルエンザウイルス増殖 (2012)
  • Author(s): 佐々木 裕、萩原 恭二、山田 和範、村上 知行、間 陽子
  • Organizer: 第60回日本ウイルス学会学術集会
  • Place of Presentation: グランキューブ大阪
• [Presentation] Visualizing Vpr-induced G2 Arrest and Apoptosis (2012)
  • Author(s): Tomoyuki Murakami , Yoko Aida
  • Organizer: 24th Workshop on Retroviral Pathogenesis
  • Place of Presentation: アメリカ
• [Presentation] Identification of Conserved Amino Acids in the Influenza a Virus Nucleoprotein by Homology Analysis and Mutational Analysis (2012)
  • Author(s): Michinori Kakisaka, Yutaka Sasaki, Kazunori Yamada, Yoko Aida
  • Organizer: 4th Workshop on Retroviral Pathogenesis
  • Place of Presentation: アメリカ
• [Presentation] どうする?牛白血病 (2011)
  • Author(s): 間陽子
  • Organizer: 牛白血病の新しい疾病防御対策、平成23年度技術懇談会-第2回-
  • Place of Presentation: 千葉県農業共済組合連合会中央家畜診療所(千葉市)(招待講演)
  • Year and Date: 2011-12-06
• [Presentation] 牛白血病のワクチン開発と新しい疾病防御対策 (2011)
  • Author(s): 間陽子
  • Organizer: 平成23年度大分県家畜保健衛生及び畜産関係業発表会
  • Place of Presentation: 大分県庁(大分市)(招待講演)
  • Year and Date: 2011-11-21
• [Presentation] 『私も獣医です』色々な職場に勤める先輩獣医師の話を聞こう (2011)
  • Author(s): 間陽子
  • Organizer: 日本大学講演
  • Place of Presentation: 日本大学(藤沢市)(招待講演)
  • Year and Date: 2011-05-21
• [Presentation] フィリピン固有品種におけるウシMHC クラスII DRB3 遺伝子の頻度解析 (2011)
  • Author(s): 大橋未来、竹嶋伸之輔、宮坂卓、松本有生、Claro N. Mingala、小沼操、間陽子
  • Organizer: 第20回日本組織適合性学会大会
  • Place of Presentation: 東京
• [Presentation] 主成分分析および立体構造解析によ るMHC の多様性に基づく牛MHC クラスII 分 子の機能予測 (2011)
  • Author(s): 竹嶋伸之輔、松本有生、Giovambattista G., 山岸純也、沖本憲明、Arainga M.,宮坂卓、 間陽子
  • Organizer: 第20回日本組織適合性学会大会
  • Place of Presentation: 東京
• [Presentation] Polymorphism of major histocompatibility complex class II associated to disease progression of bovine leukemia virus induced lymphosarcoma (2011)
  • Author(s): 間陽子、竹嶋伸之輔、松本有生、宮坂卓、宮崎義之、田邉義弘、W. C. Davis、岡田幸助
  • Organizer: 第4回HTLV-1研究会
• [Presentation] BLV-CoCoMo-qPCR: comparison of other real-time PCR methods for BLV proviral detection (2011)
  • Author(s): Jimba M., Takeshima S-n., Matusmoto Y., Arainga M., Ymadada K., Miyazaki K., Kim J., Miyasaka T., Aida Y
  • Organizer: The XXV Symposium of the International Association for Comparative Researchi on Leukemia and Related Diseases
• [Presentation] Th epitope mapping of BLV envelope protein for disease susceptibility cattle determined by major hisutocompatibility complex class II DRB3 allele (2011)
  • Author(s): Takeshima S-n., Hagiwara K., Matsumoto Y., Kim J., Miyasaka T., Jimba M., Hibishima T., Ohmori T., Nunoya T., Matoba K., Aida Y
  • Organizer: The XXV Symposium of the International Association for Comparative Researchi on Leukemia and Related Diseases
• [Presentation] Bovine MHC class II DR molecule plays A key role in bovine leukemia virus(BLV) . induced lymphoma (2011)
  • Author(s): Aida Y., Takeshima S-n., Matsumoto Y., Miyasaka T., Miyazaki Y., Tanabe Y., W. C.Davis, Okada K
  • Organizer: 15^(th) International Conference On Human Retrovirology HTLV And Related Viruses, Belgium
• [Presentation] Bovine MHC class II DR molecule plays A key role in bovine leukemia virus (BLV)-induced lymphoma (2011)
  • Author(s): Yoko Aida, Shin-nosuke Takeshima, Yuki Matsumoto, Taku Miyasaka, Yoshiyuki Miyazaki, Yoshihiro Tanabe, William C.Davis, Kosuke Okada
  • Organizer: 15^<th> International Conference On Human Retrovirology HTLV And Related Viruses
  • Place of Presentation: ベルギー
• [Presentation] BLV-CoCoMo-qPCR : comparison of other detection methods for BLV infection and kinetics analysis in experimental transmission of BLV in cattle (2011)
  • Author(s): Mayuko Jimba, Shin-nosuke Takeshima, Yuki Matsumoto, Naohiko Kobayashi, Tamako Matsuhashi, Junko Kohara, Yoko Aida
  • Organizer: 15^<th> International Conference On Human Retrovirology HTLV And Related Viruses
  • Place of Presentation: ベルギー
• [Presentation] Regulation of host cellular gene transcription by Bovine Leukemia Virus (BLV) Tax, wild type and mutants (2011)
  • Author(s): Mariluz Arainga-Ramirez, Eri Takeda, Yoko Aida
  • Organizer: 15^<th> International Conference On Human Retrovirology HTLV And Related Viruses
  • Place of Presentation: ベルギー
• [Presentation] Imaging and microarray analyses of cell cycle arrest and apoptosis by Human T cell Leukemia Virus type 1 (HTLV-1) Tax (2011)
  • Author(s): Mariluz Arainga-Ramirez, Yoko Aida
  • Organizer: 15^<th> International Conference On Human Retrovirology HTLV And Related Viruses
  • Place of Presentation: ベルギー
• [Presentation] 炭酸アパタイト粒子によるマウスへの免疫誘導 (2011)
  • Author(s): 多田誠一、蛇島武久、竹嶋伸之輔、赤池敏広、間陽子、伊藤嘉浩
  • Organizer: 第27回日本DDS学会学術集会
  • Place of Presentation: 東京大学(東京都)
• [Presentation] 牛白血病ウイルス感受性ウシMHCクラスII分子から得られた抗原ペプチドの同定および結合親和力解析 (2011)
  • Author(s): 金智潤、竹嶋伸之輔、沖本憲明、山岸純也、堂前直、萩原恭二、間陽子
  • Organizer: 第20回日本組織適合性学会大会
  • Place of Presentation: ツインメッセ静岡(静岡市)
• [Presentation] 主成分分析および立体構造解析によるMHCの多様性に基づく牛MHCクラスII分子の機能予測 (2011)
  • Author(s): 竹嶋伸之輔、松本有生、Guillermo Giovambattista、山岸純也、沖本憲明、Mariluz Arainga-Ramirez、宮坂卓、間陽子
  • Organizer: 第20回日本組織適合性学会大会
  • Place of Presentation: ツインメッセ静岡(静岡市)
• [Presentation] フィリピン固有品種におけるウシMHCクラスII DRB3遺伝子の頻度解析 (2011)
  • Author(s): 大橋未来、竹嶋伸之輔、宮坂卓、松本有生、Claro N.Mingala、小沼操、間陽子
  • Organizer: 第20回日本組織適合性学会大会
  • Place of Presentation: ツインメッセ静岡(静岡市)
• [Presentation] Polymorphism of major histocompatibility complex class II associated to disease progression of bovine leukemia virus induced lymphosarcoma (2011)
  • Author(s): Yoko Aida, Shin-nosuke Takeshima, Yuki Matsumoto, Taku Miyasaka, Yoshiyuki Miyazaki, Yoshihiro Tanabe, William C.Davis, Kosuke Okada
  • Organizer: The XXV Symposium of the Internarional Association for Comparative Reserch on Leukemia and Related Diseases
  • Place of Presentation: 東京大学(東京都)
• [Presentation] Th epitope mapping of BLV envelope protein for desease susceptibility cattle determined by major hustocompatibility complex class II DRB3 allele (2011)
  • Author(s): Shin-nosuke Takeshima, Kyoji Hagiwara, Yuki Matsumoto, Jiyun Kim, Taku Miyasaka, Mayuko Jimba, Takehisa Hebishima, Takashi Ohmori, Tetsuo Nunoya, Kazuhiro Matoba, Yoko Aida
  • Organizer: The XXV Symposium of the Internarional Association for Comparative Reserch on Leukemia and Related Diseases
  • Place of Presentation: 東京大学(東京都)
• [Presentation] BLV-Co-Co-Mo-qPCR : comparison of other real-time PCR methods for BLV proviral detection (2011)
  • Author(s): Mayuko Jimba, Shin-nosuke Takeshima, Yuki Matsumoto, Mariluz Arainga-Ramirez, Kazunori Yamada, Kazuyuki Miyazaki, Jiyun Kim, Taku Miyasaka, Yoko Aida
  • Organizer: The XXV Symposium of the Internarional Association for Comparative Reserch on Leukemia and Related Diseases
  • Place of Presentation: 東京大学(東京都)
• [Presentation] Polymorphism of major histocompatibility complex class II associated to disease progression of bovine leukemia virus induced lymphosarcoma (2011)
  • Author(s): 間陽子、竹嶋伸之輔、松本有生、宮坂卓、宮崎義之、田邉義弘、William C.Davis、岡田幸助
  • Organizer: 第4回HTLV-1研究会
  • Place of Presentation: 東京大学(東京都)
• [Presentation] Th epitope mapping of BLV envelope protein for desease susceptibility cattle determined by major hustocompatibility complex class II DRB3 allele (2011)
  • Author(s): 竹嶋伸之輔、萩原恭二、松本有生、金智潤、宮坂卓、神馬繭子、蛇島武久、大森崇史、布谷鉄夫、的場和弘、間陽子
  • Organizer: 第4回HTLV-1研究会
  • Place of Presentation: 東京大学(東京都)
• [Presentation] BLV-Co-Co-Mo-qPCR : comparison of other real-time PCR methods for BLV proviral detection (2011)
  • Author(s): 神馬繭子、竹嶋伸之輔、松本有生、Mariluz Arainga-Ramirez、山田和範、宮崎義之、金智潤、宮坂卓、間陽子
  • Organizer: 第4回HTLV-1研究会
  • Place of Presentation: 東京大学(東京都)
• [Presentation] BLV感染牛の凍結初乳給与による新生子牛の感染状況について (2011)
  • Author(s): 山本祐輔、日高健雅、今井佳積、尾形康弘、吉上渉、間陽子、竹嶋伸之輔、松本有生
  • Organizer: 平成23年度広島県家畜保健衛生及び畜産関係業発表会
  • Place of Presentation: ホテルグランヴィア広島(広島市)
• [Presentation] ウシ主要組織適合抗原(MHC)クラスII遺伝子のハプロタイプの解析 (2011)
  • Author(s): 宮坂卓、竹嶋伸之輔、泉對博、間陽子
  • Organizer: 私立大学戦略的研究基盤形成支援事業「人獣共通感染症の戦略的国際疫学研究の推進と若手研究者の実践的育成」公開シンポジウム「野生動物における人獣共通感染症の実態と研究の取り組み」
  • Place of Presentation: 日本大学(藤沢市)
• [Presentation] The distribution of bovine major histocompatibility complex class II DRB3 alleles in different herds of Japanese Black and Holstein cattle in Japan (2010)
  • Author(s): 宮坂卓、竹嶋伸之輔、松本有生, 小林直彦、松橋珠子、石橋和樹, 泉對博、間陽子
  • Organizer: 「人獣共通感染症の戦略的国際疫学研究の推進と若手研究者の実践的育成」平成22年度公開シンポジウム「食品由来人獣共通感染症の現状と対策」におけるポスターセッション
  • Place of Presentation: 神奈川 藤沢
  • Year and Date: 2010-12-18
• [Presentation] 牛白血病毒致病机理的研究(牛白血病病原性発現機構の解明) (2010)
  • Author(s): 間陽子
  • Organizer: 山東省農業大学講演
  • Place of Presentation: 中国 山東省 済南市
  • Year and Date: 2010-10-29
• [Presentation] 乳用牛における牛白血病の病態及び発症要因調査 (2010)
  • Author(s): 富田啓介、中条正樹、塚本洋、柴折浩幸、岡畑一幸、矢島和枝、浦本京也、竹嶋伸之輔、松本有生、間陽子
  • Organizer: 日本産業動物獣医学会
  • Place of Presentation: 大阪 泉佐野市
  • Year and Date: 2010-10-10
• [Presentation] Mechanism of Leukemogenesis Induced by Bovine LeukemiaVirus (2010)
  • Author(s): 間陽子
  • Organizer: Philippine Carabao Center
  • Year and Date: 2010-09-18
• [Presentation] Mechanism of Leukemogenesis Induced by Bovine Leukemia Virus (2010)
  • Author(s): 間陽子
  • Organizer: Philippine Carabao Center
  • Place of Presentation: Nueva Ecija, Philipine
  • Year and Date: 2010-09-08
• [Presentation] Association between bovine major histocompatibility complex (BOLA) class II alleles and cattle mastitis (2010)
  • Author(s): 竹嶋伸之輔、間陽子
  • Organizer: Institute for Animal Health, Compton Laboratory
  • Place of Presentation: London, England
  • Year and Date: 2010-08-03
• [Presentation] Mechanism of leukemogenesis induced by bovine leukemia virus (2010)
  • Author(s): 間陽子
  • Organizer: Institute for Animal Health, Compton Laboratory
  • Place of Presentation: London, England
  • Year and Date: 2010-08-03
• [Presentation] 牛白血病の世界における感染拡大の現状 (2010)
  • Author(s): 間陽子
  • Organizer: 農林水産省動物医薬品検査所
  • Place of Presentation: 東京
  • Year and Date: 2010-07-13
• [Presentation] 牛白血病の世界における感染拡大の現状 (2010)
  • Author(s): 間陽子
  • Organizer: 農林水産省動物医薬品検査所講演
  • Place of Presentation: 国分寺市、東京
  • Year and Date: 2010-07-13
• [Presentation] 黒毛和種とホルスタイン集団におけるウシMHC クラスII 遺伝子の多様性 (2010)
  • Author(s): 宮坂卓、竹嶋伸之輔、松本有生、小林直彦、松橋珠子、石橋和樹、泉對博、間陽子
  • Organizer: 日本組織適合性学会
  • Place of Presentation: 東京
• [Presentation] 南米大陸におけるウシMHC クラスIIDRB3 遺伝子の頻度解析 (2010)
  • Author(s): 竹嶋信之輔、松本有生、Arainga M.、金智潤、宮坂卓、薛光愛、Veronica Gabrieladela Barra、Giovambttista G.、小沼操、間陽子
  • Organizer: 日本組織適合性学会
  • Place of Presentation: 東京
• [Presentation] Distribution of Major histocompatibility complex DRB3 allelic frequencies in the 11 South American breeds of cattle (2010)
  • Author(s): 竹嶋伸之輔、松本有生、Arainga M.、金智潤、宮坂卓、薛光愛、DE LA BARRA,Gabriela V., Giovambattista G.,小沼操、間陽子
  • Organizer: 9th IVIS
  • Place of Presentation: 東京
• [Presentation] Bovine MHC class II and infectious diseases (2010)
  • Author(s): 竹嶋伸之輔、間陽子
  • Organizer: 9th IVIS
  • Place of Presentation: 東京
• [Presentation] Variation of cattle major histocompatibility complex(BOLA)DRB3 allele frequencies within different farm,breed and coutries in South America (2010)
  • Author(s): 竹嶋伸之輔、松本有生、Arainga M., 金智潤、宮坂卓、薛光愛、 Veronica Gabriela de la Barra Diaz, Giovambattista G., Enrique PofcherJ., Hermelinda,Rivera-Geronimo, 斉藤英樹,Thomas Acosta J.,印牧美佐生、 Manuel Ortiz L., Jorge Oltra,小沼操、 間陽子
  • Organizer: 32nd Conference of the International Society for Animal Genetics
  • Place of Presentation: スコットランド
• [Presentation] Bovine major histocompatibility complex class II and disease association (2010)
  • Author(s): 竹嶋伸之輔、間陽子
  • Organizer: Molecular and population genetics for improvement of farm animals and their products
  • Place of Presentation: Jastrzebiec, Poland
• [Presentation] Variation of cattle major histocompatibility complex(BOLA)DRB3 allele frequencies within different farm, breed and coutries in South America (2010)
  • Author(s): 竹嶋伸之輔, 松本有生, Arainga Ramirez Mariluz Anamelva, 金智潤, 宮坂卓, 薜光愛、Veronica Gabriela de la Barra Diaz, Guillermo Giovambattista, EnriquePofcher J., Hermelinda, Rivera-Geronimo, 斉藤英樹, Thomas Acosta J., 印牧美佐生, Manuel Ortiz L., Jorge Oltra, 小沼操, 間陽子
  • Organizer: 32nd Conference of the International Society for Animal Genetics
  • Place of Presentation: Edinburgh, Scotland
• [Presentation] BLV-CoCoMo-qPCR : Quantitation of bovine leukemia virus proviral load using CoCoMo algorism (2010)
  • Author(s): 間陽子、神馬繭子、竹嶋伸之輔、松本有生、小林直彦、松橋珠子、的場和弘、遠藤大二
  • Organizer: 2nd Conference of the International Society for Animal Genetics
  • Place of Presentation: Edinburgh, Scotland
• [Presentation] Diversity of BOLA class II DRB3 and DQA1 alleles among different herds of Japanese Black and Holstein cattle in Japan (2010)
  • Author(s): 宮坂卓、竹嶋伸之輔、松本有生、小林直彦、松橋珠子、石橋和樹、泉對博、間陽子
  • Organizer: The 9^<th> International Veterinary Immunology Symposium(9th IVIS)
  • Place of Presentation: 東京
• [Presentation] Characterization of Bovine Leukemia Virus Tax protein and its mutants (2010)
  • Author(s): Arainga Ramirez Mariluz Anamelva、武田英里、間陽子
  • Organizer: The 9^<th> International Veterinary Immunology Symposium(9th IVIS)
  • Place of Presentation: 東京
• [Presentation] Distribution of Major histocompatibility complex DRB3 allelic frequencies the 11 South American breeds of cattle (2010)
  • Author(s): 竹嶋伸之輔, 松本有生, Arainga Ramirez Mariluz Anamelva, 金智潤, 宮坂卓, 薜光愛, DE LA BARRA, Veronica Gabriela, Giovambattista Guillermo, 小沼操、間陽子
  • Organizer: The 9^<th> International Veterinary Immunology Symposium(9th IVIS)
  • Place of Presentation: 東京
• [Presentation] BoLa-DR molecule plays a key Role in bovine leukemia virus-induced lymphoma (2010)
  • Author(s): 間陽子、竹嶋伸之輔、Davis William C、小沼操、岡田幸助
  • Organizer: The 9^<th> International Veterinary Immunology Symposium(9th IVIS)
  • Place of Presentation: 東京
• [Presentation] Development of A new quantitative real-time PCR method CoCoMo primers and its clinical application (2010)
  • Author(s): 神馬繭子、竹嶋伸之輔、的場和弘、Davis William C、遠藤大二、間陽子
  • Organizer: The 9^<th> International Veterinary Immunology Symposium(9th IVIS)
  • Place of Presentation: 東京
• [Presentation] Bovine MHC class II and infectious diseases (2010)
  • Author(s): 竹嶋伸之輔、間陽子
  • Organizer: The 9^<th> International Veterinary Immunology Symposium(9th IVIS)
  • Place of Presentation: 東京
• [Presentation] 黒毛和種とホルスタイン集団におけるウシMHCクラスII遺伝子の多様性 (2010)
  • Author(s): 宮坂卓、竹嶋伸之輔、松本有生, 小林直彦、松橋珠子、石橋和樹, 泉對博、間陽子
  • Organizer: 第19回日本組織適合性学会大会
  • Place of Presentation: 東京
• [Presentation] 南米大陸におけるウシMHCクラスIIDRB3遺伝子の頻度解析 (2010)
  • Author(s): 竹嶋伸之輔、松本有生、Mariluz Arainga、金智潤、宮坂卓、薜光愛、Veronica Gabriela de la Barra, Gullermo Giovambttista、小沼操、間陽子
  • Organizer: 第19回日本組織適合性学会大会
  • Place of Presentation: 東京
• [Patent(Industrial Property Rights)] 新規なポリペプチドとその応用 (2013)
  • Inventor(s): 間陽子、竹嶋伸之輔
  • Industrial Property Rights Holder: 独立行政法人理化学研究所
  • Industrial Property Number: 2013-067683
  • Filing Date: 2013-03-27
• [Patent(Industrial Property Rights)] ウシ白血病ウイルス検出用プライマーセット、及びその利用 (2012)
  • Inventor(s): 間陽子、竹嶋伸之輔、神馬繭子、河原紀三郎、斎藤督、村松祐里、袁媛
  • Industrial Property Rights Holder: 独立行政法人理化学研究所 株式会社理研ジェネシス
  • Industrial Property Number: 2012-179972
  • Filing Date: 2012-08-14
• [Patent(Industrial Property Rights)] BLV-CoCoMo-qPCR: Quantitation of bovine leukemia virus proviral load using the CoCoMo algorithm (2010)
  • Inventor(s): Yoko AIDA, Shin-nosuke TAKESHIMA, Mayuko JIMBA, Daiji ENDOH
  • Industrial Property Rights Holder: 独立行政法人理化学研究所
  • Filing Date: 2010-10-21
  • Overseas
• [Patent(Industrial Property Rights)] BLV-CoCoMo-qPCR : Quantitation of bovine leukemia virus proviral load using the CoCoMo algorithm (2010)
  • Inventor(s): 間陽子, 竹嶋伸之輔, 神馬繭子, 遠藤大二
  • Industrial Property Rights Holder: 理化学研究所
  • Filing Date: 2010-10-21
  • Overseas