Epidemiological study for association between Helicobacter infection and gastrointestinal diseases
Project/Area Number |
22406026
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 海外学術 |
Research Field |
Gastroenterology
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Research Institution | Kobe University |
Principal Investigator |
AZUMA Takeshi 神戸大学, 医学研究科, 教授 (60221040)
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Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Masaru 神戸大学, 医学研究科, 准教授 (00419475)
KUTUMI Hiromu 神戸大学, 医学研究科, 医学研究科 (70420461)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2010: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
|
Keywords | Helicobacter感染 / 消化器疾患 / 疫学調査 / ピロリ菌 / ハイルマニ菌 / アジア / H.pylori / 感染症 |
Research Abstract |
In this study, we investigated the relationship between Helicobacterinfection (H. pylori and H. suis) and gastrointestinal diseases in Asian and African countries. H. pyloriis a group I carcinogen in human. CagA is a most important virulent factor of H. pyloriassociate with gastric cancer. The prevalence of East Asian CagA was significantly higher in patients with gastric cancer than in patients with chronic gastritis. The much greater magnitude of risk observed with East Asian CagA-positive H. pyloriinfection. Therefore, patients harboring East Asian CagA-positive H. pylori are at a higher risk for developing gastric cancer than those infected with Western CagA-positive strains. H. suis, which belongs to the Helicobacterfamily just like H. pylori, was found in the stomachs of various animals including cats, dogs and pigs, and furthermore humans. H. suis infection caused gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Th1 host response was predominant in H. pyloriinfection. In contrast, both Th1 and Th2 host response were up-regulated in H. suisinfection.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Genome-wide survey of mutual homologous recombination in a highly sexual bacterial species2012
Author(s)
Yahara K, Kawai M, Furuta Y, Takahashi N, Handa N, Tsuru T, Oshima K, Yoshida M, Azuma T, Hattori M, Uchiyama I, Kobayashi I.
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Journal Title
Genome Biol Evol
Volume: 4(5)
Pages: 628-40
Related Report
Peer Reviewed
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[Journal Article] IFN-γ plays an essential role in the pathogenesis of gastric lymphoid follicles formation caused by Helicobacter suis infection.2011
Author(s)
Mimura T, Yoshida M, Nishiumi S, Tanaka H, Nobutani K, Takenaka M, Suleiman YB, Yamamoto K, Ota H, Takahashi S, Matsui H, Nakamura M, Miki I, Azuma T.
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Journal Title
FEMS Immunol Med Microbiol.
Volume: 63(1)
Pages: 25-34
Related Report
Peer Reviewed
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[Journal Article] Helicobacter suis KB1 derived from pig gastric lymphoid follicles induces the formation of gastric lymphoid follicles in mice through the activation of B cells and CD4 positive cells.2011
Author(s)
Yamamoto K, Tanaka H, Nishitani Y, Nishiumi S, Miki I, Takenaka M, Nobutani K, Mimura T, Ben Suleiman Y, Mizuno S, Kawai M, Uchiyama I, Yoshida M, Azuma T.
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Journal Title
Microbes Infect
Volume: 13(7)
Pages: 697-708
Related Report
Peer Reviewed
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[Journal Article] Evolution in an oncogenic bacterial species with extreme genome plasticity: Helicobacter pyloriEast Asian genomes.2011
Author(s)
Kawai M, Furuta Y, Yahara K, Tsuru T, Oshima K, Handa N, Takahashi N, Yoshida M, Azuma T, Hattori M, Uchiyama I, Kobayashi I.
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Journal Title
BMC Microbiol
Volume: 11
Pages: 104-104
Related Report
Peer Reviewed
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[Journal Article] Birth and death of genes linked to chromosomal inversion.2011
Author(s)
Furuta Y, Kawai M, Yahara K, Takahashi N, Handa N, Tsuru T, Oshima K, Yoshida M, Azuma T, Hattori M, Uchiyama I, Kobayashi I.
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 108(4)
Pages: 1501-6
Related Report
Peer Reviewed
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[Journal Article] Helicobacter heilmannii can induce gastric lymphoid follicles in mice via a Peyer's patch-independent pathway.2010
Author(s)
Nobutani K, Yoshida M, Nishiumi S, Nishitani Y, Takagawa T, Tanaka H, Yamamoto K, Mimura T, Bensuleiman Y, Ota H, Takahashi S, Matsui H, Nakamura M, Azuma T.
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Journal Title
FEMS Immunol Med Microbiol
Volume: 60(2)
Pages: 156-64
Related Report
Peer Reviewed
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[Journal Article] Prescreening of a high-risk group for gastric cancer by serologically determined Helicobacter pylori infection and atrophic gastritis.2010
Author(s)
Mizuno S, Miki I, Ishida T, Yoshida M, Onoyama M, Azuma T, Habu Y, Inokuchi H, Ozasa K, Miki K, Watanabe Y.
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Journal Title
Dig Dis Sci
Volume: 55(11)
Pages: 3132-7
Related Report
Peer Reviewed
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[Journal Article] Diversity of the cagA gene of Helicobacter pylori strains from patients with gastroduodenal diseases in the Philippines.2010
Author(s)
Cortes MC, Yamakawa A, Casingal CR, Fajardo LS, Juan ML, De Guzman BB, Bondoc EM; St. Luke's Helicobacter pylori Study Group, Mahachai V, Yamazaki Y, Yoshida M, Kutsumi H, Natividad FF, Azuma T.
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Journal Title
FEMS Immunol Med Microbiol.
Volume: 60(1)
Pages: 90-7
Related Report
Peer Reviewed
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