International collaborative research on the etiology for intractable kidney disease children in East Asia
| Project/Area Number |
22406027
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Pediatrics
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2010: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Keywords | 腎不全 / 疾患遺伝子 / ネフローゼ / ポドサイト / シークエンス / 難治性腎疾患 / エクソーム / 間質性腎炎 / 尿細管障害 / 連鎖解析 / ゲノム / 慢性腎臓病 / 腎尿細管 |
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| Research Abstract |
Steroid-resistant nephrotic syndrome (SRNS) is a major cause of end-stage renal disease in children. More than 10 SRNS disease genes have been reported to date. However, there is a considerable ethnic difference in the prevalence of the genes. In particular, the molecular basis of early childhood onset SRNS in Asian is still largely unknown. The aim of this study was to identify the disease genes highly specific to Asians through international collaboration. The linkage mapping 16 Asian SRNS families of recessive inheritance revealed several candidate loci with HLOD scores>3.0, suggesting that multiple genes rather than a single major gene may be involved. In 4 autosomal-dominant types of SRNS families, we found INF2 mutations, which are reported to account for 10- 20 % of dominant SRNS in Caucasians and African Americans. Whole exome analysis is now being on progress to clarify the genes in other families in which genes are yet to be determined
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Glomerular proteins related to slit diaphragm and matrix adhesion in the foot processes are highly tyrosine phosphorylated in the normal rat kidney.2010
Author(s)
Zhang Y, Yoshida Y, Nameta M, Xu B, Taguchi I, Ikeda T, Fujinaka H, Mohamed SM, Tsukaguchi H, Harita Y, Yaoita E, Yamamoto T.
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Journal Title
Nephrol Dial Transplant.
Volume: 25(6)
Pages: 1785-1795
Related Report
Peer Reviewed
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[Presentation] 家族性lgA腎症の遺伝解析2010
Author(s)
後藤眞, 和田真一, 塚口裕康, 福田陽子, 坂爪実, 辻省次, 成田一衛
Organizer
第53回日本腎臓学会学術集会・総会
Place of Presentation
神戸国際会議場
Year and Date
2010-06-18
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