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Establishing a global base in treatment of radiation injuries

Research Project

Project/Area Number 22406030
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Plastic surgery
Research InstitutionNagasaki University

Principal Investigator

AKITA Sadanori  長崎大学, 大学病院, 助教 (90315250)

Co-Investigator(Kenkyū-buntansha) YAMASHITA Shunichi  長崎大学, 医歯薬学総合研究科, 教授 (30200679)
OHTSURU Akira  福島県立医科大学, 医学部, 教授 (00233198)
FUJIOKA Masaki  独立行政法人国立病院機構, 長崎医療センター, 研究員 (70393452)
長谷 敦子  長崎大学, 病院, 准教授 (50228037)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Keywords国際連携 / 放射線障害 / 国際創傷ネットワーク / 治療ガイドライン / 幹細胞治療 / 放射線防護 / サイトカイン / REMPAN会議 / REAC/TSシンポジウム / 人工真皮 / 同時植皮 / 自家細胞 / 再生医療 / ロシア / アジア連携 / クロアチア / hands-onプログラム / 急性放射線障害モデル / 放射線医学データベース / 大学間連携 / 自家脂肪幹細胞移植
Research Abstract

Protective effect of skin soft tissue was validated immediately after external irradiation (10Gy) by continuous administration of basic fibroblast growth factor (bFGF) as acute radiation injury model in the local radiation damage.Autologous adipose-derived stem cell therapy is safe and effective in treatment of chronic radiation injuries. For possible application of stem cell therapy for acute as well as chronic injuries, the construction of the international joint project with a quote from neighboring Asian countries, including China, Russia and South Korea, the old Russia, Europe, and USA was proposed.The joint meeting with the biological Nagasaki University and 125thThe principal investigator played a role of an organizer as the secretary general.anniversary-RussianSaint Petersburg Medical Academy of Postgraduate Studies in June, 2010, Principal Investigator was awarded to a visiting professor in November 2010. Announced 13th Coordination and planning meeting of the REMPAN (Radiation Emergency Medical Preparedness and Assistance Network) meeting was held in Nagasaki, February, 2011, where the a joint international project was expanded. Fourth World Union of Wound Healing Societies (WUWHS) was held in September, 2012 Yokohama and the former Soviet Union, China, the Philippines, based on the participation in more than 50 countries, 3,500, practical study and world network construction recommendations of wound , to discuss neighboring Asian countries South Korea, Taiwan, Singapore, and Indonesia, and the United States of America professional and European countries, was invited to participate Transontinental Wound Registty to (intercontinental wound registration) database and realization of radiation damage center project.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (58 results)

All 2013 2012 2011 2010 2005 2004 1998 Other

All Journal Article (19 results) (of which Peer Reviewed: 9 results) Presentation (21 results) (of which Invited: 1 results) Book (11 results) Remarks (4 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 3 results)

  • [Journal Article] The usefulness of basic fibroblast growth factor for radiation-exposed tissue2012

    • Author(s)
      Kinoshita N, Tsuda M, Hamuy R, Nakashima M, Nakamura-Kurashige T,Matsuu-Matsuyama M, Hirano A, Akita S
    • Journal Title

      Wound Repair Regen

      Volume: 20 Pages: 91-102

    • NAID

      10031181795

    • Related Report
      2012 Final Research Report
  • [Journal Article] Early experiences with stem cells in treating chronic wounds2012

    • Author(s)
      Akita S, Yoshimoto H, Akno K, Yamashita S, Hirano A
    • Journal Title

      Clin Plast Surg

      Volume: 39 Pages: 281-292

    • NAID

      120006985986

    • Related Report
      2012 Final Research Report
  • [Journal Article] Vascularised fat flaps lose 44% of their weight 24 weeks after transplantation2012

    • Author(s)
      Oashi K, Furukawa H, Akita S, Nakashima M, Matsuda K, Oyama A, Hayashi T, Hirano A, Yamamoto Y
    • Journal Title

      J Plast Reconstr Aesthet Surg

      Volume: 65 Pages: 403-409

    • Related Report
      2012 Final Research Report
  • [Journal Article] Quality of pediatric second-degree burn wound scars following the application of basic fibroblast growth factor: Results of a randomized, controlled pilot study.2012

    • Author(s)
      Hayashida K, Akita S
    • Journal Title

      Ostomy Wound Manage

      Volume: 58 Pages: 32-36

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] Autologous adipose-derived regenerative cells are effective for chronic intractable radiation injuries2012

    • Author(s)
      Akita S, Yoshimoto H, Ohtsuru A, Hirano A, Yamashita S
    • Journal Title

      Radiat Prot Dosim

      Volume: 151 Pages: 656-660

    • NAID

      120006985992

    • Related Report
      2012 Final Research Report
  • [Journal Article] The usefulness of basic fibroblast growth factor fro radiation-exposed tissue.2012

    • Author(s)
      Kinoshita N, Tsuda M, Hamuy R, Nakashima M, Nakamura-Kurashige T, Matsuu-Matsuyama M, Hirano A, Akita S
    • Journal Title

      Wound Repair Regen

      Volume: 20 Issue: 1 Pages: 91-102

    • DOI

      10.1111/j.1524-475x.2011.00758.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vascularised fat flaps lose 44% of their weight 24 weeks after transplantation.2012

    • Author(s)
      Oashi K, Furukawa H, Akita S, Nakashima M, Matsuda K, Oyama A, Hayashi T, Hirano A, Yamamoto Y.
    • Journal Title

      J Plast Reconstr Aesthet Surg

      Volume: 65 Issue: 10 Pages: 403-409

    • DOI

      10.1016/j.bjps.2012.04.036

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early experiences with stem cells in treating chronic wounds.2012

    • Author(s)
      Akita S, Yoshimoto H, Akno K, Yamashita S, Hirano A.
    • Journal Title

      Clin Plast Surg

      Volume: 39 Issue: 3 Pages: 281-292

    • DOI

      10.1016/j.cps.2012.04.005

    • NAID

      120006985986

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autologous adipose-derived regenerative cells are effective for chronic intractable radiation injuries2012

    • Author(s)
      Akita S, Yoshimoto H, Ohtsuru A, Hirano A, Yamashita S.
    • Journal Title

      Radiat Prot Dosimetry

      Volume: 151 Pages: 656-660

    • NAID

      120006985992

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] No evidence of association between 8q24 and susceptibility to nonsyndromic cleft lip with or without palate in Japanese population2011

    • Author(s)
      Hikida M, Tsuda M, Watanabe A, Kinoshita A, Akita S, Uchiyama T, Yoshiura KI
    • Journal Title

      Cleft Palate Craniofac J

      Volume: (epub ahead of print)

    • Related Report
      2012 Final Research Report
  • [Journal Article] Basic FGF in scarless wound healing2011

    • Author(s)
      Akita S
    • Journal Title

      Wound Healing Society Year Book-Advances in Wound Care

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early experiences with stem cells in treating chronic wounds2011

    • Author(s)
      Akita S, Yoshimoto H, Akino K, Yamashita S, Hirano A
    • Journal Title

      Clin Plast Surg

      Volume: (in press)

    • NAID

      120006985986

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mesenchymal stem cell therapy for cutaneous radiation syndrome2010

    • Author(s)
      Akita S, Akino K, Hirano A, Ohtsuru A, Yamashita S.
    • Journal Title

      Health Physics

      Volume: 09 Pages: 858-862

    • NAID

      120006985984

    • Related Report
      2012 Final Research Report
  • [Journal Article] 自家脂肪組織由来幹細胞を用いた放射線障害の再生医療2010

    • Author(s)
      秋田定伯
    • Journal Title

      放射線事故医療研究会会報

      Volume: 21 Pages: 6-6

    • Related Report
      2012 Final Research Report
  • [Journal Article] Basic fibroblast growth factor is beneficialfor post-operative color uniformity in split-thickness skin grafting2010

    • Author(s)
      Akita S, Akino K, Yakabe A, Tanaka K, Anraku K, Yano H, Hirano A
    • Journal Title

      Wound Repair Regen

      Volume: 18 Pages: 560-566

    • Related Report
      2012 Final Research Report
  • [Journal Article] Non-cultured autologous adipose-derived stem cells therapy for chronic radiation injury.2010

    • Author(s)
      Akita S, Akino K, Hirano A, Ohtsuru A, Yamashita S
    • Journal Title

      Stem cells International

      Volume: 532704 Pages: 1-8

    • NAID

      120006985055

    • Related Report
      2012 Final Research Report
  • [Journal Article] Non-cultured autologous adipose-derived stem cells therapy for chronic radiation injury.2010

    • Author(s)
      Akita S, Akino K, Hirano A, Ohtsuru A, Yamashita S.
    • Journal Title

      Stem cells International

      Volume: (Epub)

    • NAID

      120006985055

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Basic fibroblast growth factor is beneficial for post-operative color uniformity in split-thickness skin grafting.2010

    • Author(s)
      Akita S, Akino K, Yakabe A, Tanaka K, Anraku K, Yano H, Hirano A.
    • Journal Title

      Wound Repair Regen

      Volume: 18 Pages: 560-566

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mesenchymal stem cel therapy for cutaneous radiation syndrome2010

    • Author(s)
      Akita S, Akino K, Hirano A, Ohtsuru A, Yamashita S.
    • Journal Title

      Health Phys

      Volume: 9 Pages: 858-862

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 局所慢性放射線障害に対する再生医療2012

    • Author(s)
      秋田定伯、吉本 浩、林田健志、山下俊一、平野明喜
    • Organizer
      第55回日本形成外科学会 総会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] The ideal perspectives for wound healing reimbursement2012

    • Author(s)
      Akita S
    • Organizer
      World Union of Wound Healing Societies
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] 下肢リンパ浮腫モデルにおける脂肪由来幹細胞を用いたリンパ管再生療法2012

    • Author(s)
      吉田周平、秋田定伯、吉本 浩、Hamuy R、浜田裕一、平野明喜
    • Organizer
      第21回日本創傷外科学会 基礎学術集会
    • Place of Presentation
      福島
    • Related Report
      2012 Final Research Report
  • [Presentation] Role of autologous stem cells in DM and related intractable chronic wounds2012

    • Author(s)
      Akita S
    • Organizer
      9thAsia Pacific conference on diabetic limb problems
    • Related Report
      2012 Final Research Report
  • [Presentation] 局所放射線障害に対する再生医療2012

    • Author(s)
      秋田定伯、吉本 浩、林田健志、山下俊一、平野明喜
    • Organizer
      第55回日本形成外科学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Simultaneous artificial dermis, basic fibroblast growth factor and skin grafting result in successful graft take and improved tissue texture2012

    • Author(s)
      Hamuy R, Kinoshita N, Yoshimoto H, Hayashida K, Houbara S, Nakashima M,
    • Organizer
      SAWC/WHS annual meeting
    • Place of Presentation
      Georgia, Atlanta
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cytokine and Mesenchymal stem and regenerative cell therapy in local radiation2012

    • Author(s)
      Akita S, Yoshimoto H, Akino K, Kinoshita N, Hamuy R, Ohtsuru A, Hayashida K,
    • Organizer
      The 11th Japan-Korea Congress of Plastic and Reconstructive Surgery
    • Place of Presentation
      Awaji, Hyogo,Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] Role of stem cells in wound care-Autologous adipose-derived stem cell therapy in2012

    • Author(s)
      Akia S
    • Organizer
      1st Asia Pacific Wound Congress
    • Place of Presentation
      Kuala Lumpur
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 下肢リンパ浮腫モデルにおける脂肪由来幹細胞を用いたリンパ管再生療法2012

    • Author(s)
      吉田周平、秋田定伯、吉本 浩、Hamuy R、浜田裕一、平野明喜
    • Organizer
      第21回日本創傷外科学会 基礎学術集会
    • Place of Presentation
      福島
    • Related Report
      2012 Annual Research Report
  • [Presentation] Mesenchymal stem cell therapy for local radiation injuries-Nagasaki experience2011

    • Author(s)
      Akita S
    • Organizer
      13^<th> Coordination and planning meeting of the REMPAN
    • Place of Presentation
      Nagasaki
    • Year and Date
      2011-02-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mesenchymal stem cell therapy for local radiation injuries-Nagasaki experience2011

    • Author(s)
      Akita S
    • Organizer
      13thCoordination and planning meeting of the REMPAN
    • Place of Presentation
      Speaker, Nagasaki
    • Related Report
      2012 Final Research Report
  • [Presentation] Adult stem cell therapy and radiation injury2011

    • Author(s)
      Akita S
    • Organizer
      1st Cell Society meeting, Invited Lecture
    • Place of Presentation
      La Jolla, California
    • Related Report
      2012 Final Research Report
  • [Presentation] Mesenchymal stem cell therapy in local radiation injuries-A Japanese approach2011

    • Author(s)
      Akita S, Yoshimoto H, Akino K, Ohtsuru A, Hayashida K, Hirano A, Suzuki K, Yamashita S.
    • Organizer
      5thInternational REAC/TS (Radiation Emergency Assistance Center/Training Site)
    • Place of Presentation
      Symposium, Miami
    • Related Report
      2012 Final Research Report
  • [Presentation] Autologous mesenchymal stem cell therapy in local radiation injury-A Japanese approach2011

    • Author(s)
      Akita S, Yoshimoto H, Akino K, Ohtsuru A, Hayashida K, Hirano A, Suzuki K, Yamashita S
    • Organizer
      3rdInternational conference on regenerative surgery
    • Place of Presentation
      Rome
    • Related Report
      2012 Final Research Report
  • [Presentation] Mesenchymal stem cell therapy in local radiation injuries-A Japnese approach2011

    • Author(s)
      Akita S, Yoshimoto H, Akino K, Ohtsuru A, Hayashida K, Hirano A, Suzuki K, Yamashita S
    • Organizer
      5^<th> International REAC/TS (Radiation Emergency Assistance Center/Training Site) Symposium
    • Place of Presentation
      Miami, California
    • Related Report
      2011 Annual Research Report
  • [Presentation] Autologous stem cell delivery Wound healing congress2010

    • Author(s)
      Akita S
    • Place of Presentation
      St. Thomas, Virgin Islands, USA
    • Year and Date
      2010-12-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Regenerative medicine for intractable skin ulcer and lipodystrophy.2010

    • Author(s)
      Akita S
    • Organizer
      St.Petersburg medical academy of postgraduate studies 125th anniversaryjoint conference on biomedical sciences
    • Place of Presentation
      St. Petersburg, Russia
    • Year and Date
      2010-06-10
    • Related Report
      2012 Final Research Report
  • [Presentation] 自家脂肪由来幹細胞を用いた放射線障害に対する再生医療2010

    • Author(s)
      秋田定伯 吉本 浩 竹下順子 山下俊一 平野明喜
    • Organizer
      第53回日本形成外科学会
    • Place of Presentation
      金沢
    • Year and Date
      2010-04-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Autologous adipose-derived stem cell therapy for chronic radiation injuries2010

    • Author(s)
      Yoshimoto H, Hirano A, Akita S.
    • Organizer
      International Workshop of Wound Technology/European Tissue Repair Society joint meeting
    • Year and Date
      2010-01-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Autologous adipose-derived stem cells enhance wound healing and fat regeneration.2010

    • Author(s)
      Akita S, Akino K, Yoshimoto H, Hirano A, Yamashita S
    • Organizer
      SAWC/WHS annual meeting, international session
    • Place of Presentation
      Orlando, Florida, USA, April
    • Related Report
      2012 Final Research Report
  • [Presentation] St. Petersburg Medial Academy of Postgraduate Studies, Visiting professor2010

    • Author(s)
      Akita S.
    • Organizer
      Burn, Scar, Trauma management andregenerative medicine
    • Place of Presentation
      St. Petersburg, Russia
    • Related Report
      2012 Final Research Report
  • [Book] Necrotizing fasciitis. Skin Necrosis2013

    • Author(s)
      Akita S.
    • Total Pages
      430
    • Publisher
      Springer-Verlag
    • Related Report
      2012 Annual Research Report
  • [Book] Imaging, vascular assessment: Extension in depth and vascular anomalies. Skin Necrosis2013

    • Author(s)
      Akita S, Houbara S, Akatsuka M.
    • Total Pages
      430
    • Publisher
      Springer-Verlag
    • Related Report
      2012 Annual Research Report
  • [Book] Basic fibroblat growth factor in scarless wound healing. Year Book2013

    • Author(s)
      Akita S, Akino K, Hirano A.
    • Total Pages
      430
    • Publisher
      Wound Healing Society, Inc
    • Related Report
      2012 Annual Research Report
  • [Book] Surgical management of pressure ulcers. Surgical wound Management, Second Edition Eds2012

    • Author(s)
      Akita S.
    • Total Pages
      186
    • Publisher
      Mark S. Granick and Luc Teot, Informa Healthcare, London
    • Related Report
      2012 Final Research Report
  • [Book] 肥厚性瘢痕・ケロイドの非手術的治療創傷のすべて 市岡滋 監修、安部正敏、溝上祐子、寺師浩人編集2012

    • Author(s)
      吉本 浩、秋田定伯、平野明喜
    • Total Pages
      403
    • Publisher
      克誠堂出版
    • Related Report
      2012 Final Research Report
  • [Book] Surgical management of pressure ulcers. Surgical wound Management, Second2012

    • Author(s)
      Akita S.
    • Total Pages
      186
    • Publisher
      Informa Healthcare
    • Related Report
      2012 Annual Research Report
  • [Book] 肥厚性瘢痕・ケロイドの非手術的治療 創傷のすべて2012

    • Author(s)
      吉本 浩、秋田定伯、平野明喜
    • Total Pages
      403
    • Publisher
      克誠堂
    • Related Report
      2012 Annual Research Report
  • [Book] Surgical management of pressure ulcers. Surgical wound Management, Second Edition(Eds.Mark S.Granick and Luc Teot)2011

    • Author(s)
      Akita S.
    • Publisher
      Informa Healthcare, London(in press)
    • Related Report
      2011 Annual Research Report
  • [Book] Prevention of scar using bFGF Chapter 9: Color atlas of burn reconstructive surgery. Pp. 62-71, Eds. Hyakusoku H, Orgill DP, Teot L, Pribaz JJ, Ogawa R2010

    • Author(s)
      Akita S
    • Publisher
      Springer-Verlag, Berlin Heidelberg, 499 pages in total, 2010 Akita S, Editions MF, Paris
    • Related Report
      2012 Final Research Report
  • [Book] Color atlas of burn reconstructive surgery. (Prevention of scar using bFGF Chapter 9 : Pp.62-71)(Eds.Hyakusoku H, Orgill DP, Teot L, Pribaz JJ, Ogawa R)2010

    • Author(s)
      Akita S.
    • Total Pages
      499
    • Publisher
      Springer-Verlag, Berlin Heidelberg
    • Related Report
      2010 Annual Research Report
  • [Book] How to manage radiation injuries. SkinNecrosis, Eds. Teot L, Meaume S, Del Mamol V, Akita S, Ennis WI

    • Author(s)
      Murakami C, Fujioka M, Akita S.
    • Publisher
      Springer-Verlag, Heidelberg
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.med.nagasaki-u.ac.jp/plastics/

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.wuwhs.org/

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.med.nagasaki-u.ac.jp/plastics/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.nagasaki-u.ac.jp/plastics/

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 間葉系幹細胞の培養方法および間葉系幹細胞を用いてなる培養臓器2005

    • Inventor(s)
      秋田定伯
    • Industrial Property Rights Holder
      秋田定伯、秋野公造、中川浩志
    • Filing Date
      2005-02-10
    • Related Report
      2012 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] ITS USE FOR TESTING THERAPEUTIC DRUGS FOR THE CONDITIONS2004

    • Inventor(s)
      Melmed S, Akita S, Readhead C
    • Industrial Property Rights Holder
      Melmed S, Akita S, Readhead C
    • Acquisition Date
      2004-06-30
    • Related Report
      2012 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] TRANSGENIC MOUSE MODEL FOR PITUITARY DISORDERS ASSOCIATED WITH LIFOVER-EXPRESSION AND/OR GH UNDEREXPRESSION1998

    • Inventor(s)
      Melmed S, Akita S, Readhead C
    • Industrial Property Rights Holder
      Melmed S, Akita S, Readhead C
    • Acquisition Date
      1998-10-20
    • Related Report
      2012 Final Research Report
    • Overseas

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Published: 2010-08-23   Modified: 2019-07-29  

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