Computational model of visual information coding in the retina

• Project/Area Number: 22500280
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Bioinformatics/Life informatics
• Research Institution: Aichi Prefectural University
• Principal Investigator: KAMIYAMA Yoshimi 愛知県立大学, 情報科学部, 教授 (70233963)
• Research Collaborator: SAKURAGI Yuichiro 愛知県立大学, 大学院・情報科学研究科, 大学院生 ; SONE Daiki 愛知県立大学, 大学院・情報科学研究科, 大学院生 ; SERIZAWA Hirokazu 愛知県立大学, 大学院・情報科学研究科, 大学院生
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: ニューロインフォマティクス / 網膜 / 錐体モザイク / 神経スパイク / 数理モデル / 錐体 / 網膜神経節細胞 / スパイク誘発平均刺激 / 逆相関法 / 錐体モデイク / シミュレーション / イオンチャネル / 生体生命情報学 / 神経科学 / 色覚

Research Abstract

We developed a computational model of the cone mosaic based on the physiological and anatomical characteristics. The present model incorporated the spectral sensitivities of three types of cones, as well as the nonuniform spatial distributions of cones. The cone mosaic was generated by a stochastic algorithm to reproduce the nonuniformity. The present model covers a visual angle of 60 degrees with 2,000,000 cones. The model allows us to analyze how color information is processed in the cone mosaic. In simulation, we produced various types of cone mosaics by changing the subtype cone ratio and/or the spectral sensitivities. We analyzed how the cone mosaic limits our ability to infer the spatial and color information processing present in the retinal image. We also extended the model to include the ganglion cells for analyzing the input-output relationships in the retina.

Research Products

• [Journal Article] ニューロインフォマティクスと網膜研究 (2011)
  • Author(s): 神山斉己
  • Journal Title: 生物物理 Volume: Vol.51, No.3 Pages: 112-117
  • NAID: 10029139901
  • Peer Reviewed
• [Journal Article] 霊長類錐体モザイクの大規模数理モデル (2011)
  • Author(s): 曾根大樹, 神山斉己
  • Journal Title: 電子情報通信学会技術研究報告 Volume: NC2011-84 Pages: 1-6
• [Journal Article] 網膜錐体モザイクのリアリスティックモデル (2011)
  • Author(s): 曾根大樹, 神山斉己
  • Journal Title: 第55回システム制御情報学会研究発表会論文集 Volume: H25-2 Pages: 537-538
• [Journal Article] 生理学・解剖学的な特性に基づいた錐体視細胞の数理モデル (2010)
  • Author(s): 曾根大樹, 神山斉己
  • Journal Title: 第25回生体・生理工学シンポジウム論文集 Volume: BPES2010 Pages: 201-204
  • Peer Reviewed
• [Presentation] Computational analysis of the functional connectivity between input-output neurons of the retina (2013)
  • Author(s): Serizawa, H. and Kamiyama, Y.
  • Organizer: The 35th Annual Meeting of the Japan Neuroscience society
  • Place of Presentation: 名古屋
• [Presentation] A computational model of the trichromatic cone mosaic (2012)
  • Author(s): Kamiyama, Y. and Sone, D.
  • Organizer: Neuroinformatics 2012 Abstract
  • Place of Presentation: Munich(Germany)
• [Presentation] 網膜入出力ニューロン間の機能的結合のシミュレーション解析 (2012)
  • Author(s): 芹澤弘和, 神山斉己
  • Organizer: 第10回情報学ワークショップ (Win2012)論文集
  • Place of Presentation: 豊橋
• [Presentation] A computational model of the trichromatic cone mosaic (2012)
  • Author(s): Kamiyama, Y. and Sone, D.
  • Organizer: Neuroinformatics 2012
  • Place of Presentation: Munich, Germany
• [Presentation] Computational analysis of the functional connectivity between input-output neurons of the retina (2012)
  • Author(s): Serizawa, H. and Kamiyama, Y.
  • Organizer: The 35th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Nagoya, Japan
• [Presentation] 網膜入出力ニューロン間の機能的結合のシミュレーション解析 (2012)
  • Author(s): 芹澤弘和, 神山斉己
  • Organizer: 第10回情報学ワークショップ
  • Place of Presentation: 豊橋, 愛知県
• [Presentation] A realistic large-scale model of the retinal cone network (2011)
  • Author(s): 神山斉己, 曾根大樹, 臼井支朗
  • Organizer: Neuroinformatics 2011
  • Place of Presentation: Boston(アメリカ)
  • Year and Date: 2011-09-04
• [Presentation] A realistic large-scale model of the retina cone network (2011)
  • Author(s): Kamiyama, Y., Sone, D. and Usui, S.
  • Organizer: Neuroinformatics
  • Place of Presentation: Boston(USA)
• [Presentation] 網膜神経回路のリアリスティックモデル (2011)
  • Author(s): 神山斉己, 臼井支朗
  • Organizer: 第3回バイオスーパーコンピューティング・シンポジウム
  • Place of Presentation: 神戸
• [Presentation] 網膜錐体モザイクのリアリスティックモデル (2011)
  • Author(s): 曾根大樹, 神山斉己
  • Organizer: 第55回システム制御情報学会研究発表講演会論文集
  • Place of Presentation: 大阪
• [Presentation] 霊長類網膜錐体モザイクの大規模数理モデル (2011)
  • Author(s): 曾根大樹, 神山斉己
  • Organizer: 電子情報通信学会技術研究報告
  • Place of Presentation: 名古屋
• [Presentation] Effects of ion channels on the spike timing in the retinal ganglion cells (2010)
  • Author(s): Kamiyama, Y. and Sakuragi, Y.
  • Organizer: 19th Annual Computational Neuroscience Meeting, CNS*2010, BMC Neuroscience
  • Place of Presentation: San Antonio, Texas(USA)
• [Presentation] Analysis of the spike timing precision in retinal ganglion cells by the stochastic model (2010)
  • Author(s): Kamiyama, Y. and Sakuragi, Y.
  • Organizer: Frontiers in Neuroscience, Conference Abstract, Neuroinformatics2010
  • Place of Presentation: Kobe(Japan)
• [Presentation] 生理学・解剖学的な特性に基づいた錐体視細胞の数理モデル (2010)
  • Author(s): 曾根大樹, 神山斉己
  • Organizer: 第25回生体・生理工学シンポジウム論文集
  • Place of Presentation: 岡山大学
• [Presentation] Effects of ion channels on the spike timing in the retinal ganglion cells (2010)
  • Author(s): 神山斉己
  • Organizer: 19^<th> Annual Computational Neuroscience Meeting
  • Place of Presentation: San Antonio(アメリカ)
• [Presentation] Analysis of the spike timing precision in retinal ganglion cells by the stochastic model (2010)
  • Author(s): 神山斉己
  • Organizer: Neuroinformatics 2010
  • Place of Presentation: 神戸