Ionic mechanisms of CO2 sensitivity in Phox2b neurons as the medullary central chemoreceptor
| Project/Area Number |
22500296
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
IKEDA Keiko 自治医科大学, 医学部, 准教授 (10265241)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 呼吸中枢 / 延髄 / 中枢化学受容器 / Phox2b / 呼吸リズム形成 |
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| Research Abstract |
It has been suggested that Phox2b expressing cells including pFRG/Pre-I neurons in the rostral ventrolateral medulla function as the central chemoreceptors (i.e. CO2 sensor). In the present study, we investigated neuronal mechanisms of high CO2 reception of pFRG/Pre-I neurons, using the brainstem-spinal cord preparation from newborn rats. The CO2 sensitivity of pFRG/Pre-I neurons was preserved even after blockade of Na+channels and Ca2+channels, and the membrane depolarization induced by hypercapnic stimulation was mainly due to the closing of K+channels. We also found that Phox2b-expressing cells including pFRG/Pre-I neurons in the parafacial region of the rostral ventral medulla tended to assemble around capillary blood vessels. We confirmed that TASK1,2 and 3 channels were less significantly involved in hypercapnic responses of pFRG/Pre-I neurons. Our findings demonstrate that the pFRG/Pre-I neurons possess postsynaptic mechanisms that are directly responsible to high CO2 stimulation.
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Report
(4 results)
Research Products
(62 results)
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[Journal Article] Importance of rostral ventrolateral medulla neurons in determining efferent sympathetic nerve activity and blood pressure2012
Author(s)
Kumagai H, Oshima N, Matsuura T, Iigaya K,ImaiM,OnimaruH,SakataK,OsakaM,OnamiT,TakimotoC,KamayachiT,ItohH,SarutaT
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Journal Title
Hypertens Res
Volume: 35(2)
Pages: 132-41
NAID
Related Report
Peer Reviewed
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[Journal Article] Importance of rostral ventrolateral medulla neurons in determining efferent sympathetic nerve activity and blood pressure.2012
Author(s)
Kumagai H, Oshima N, Matsuura T, Iigaya K, Imai M, Onimaru H, Sakata K, Osaka M, Onami T, Takimoto C, Kamayachi T, Itoh H, Saruta T.
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Journal Title
Hypertens Res.
Volume: 35
Pages: 132-141
NAID
Related Report
Peer Reviewed
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