Visualization of the sexual differentiation in the sexually dimorphic nucleus of the preoptic area.
Project/Area Number |
22500297
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neuroscience in general
|
Research Institution | Nippon Medical School |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
SAKUMA Yasuo 東京医療学院大学, 保健医療学部, 教授 (70094307)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 性分化 / 視索前野性的二型核 / 可視化 / 細胞移動 / エストロゲン / 性差 / 分界条床核 |
Research Abstract |
The sexually dimorphic nucleus in the preoptic area (SDN-POA) is larger in males than in females, however the mechanism of sexual differentiation of this structure remains largely unknown, except that androgen and/or estrogen during perinatal period cause the establishment of male-typical nuclei. We have shown recently that enhanced green fluorescent protein (EGFP) is expressed in the SDN-POA under the control of an estrogen receptor α gene promoter. The present study suggested that neural migration plays a key role in the sexual differentiation of the SDN-POA to visualize the nucleogenesis of the SDN-POA in vivo and in vitro.
|
Report
(4 results)
Research Products
(30 results)