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Visualization of the sexual differentiation in the sexually dimorphic nucleus of the preoptic area.

Research Project

Project/Area Number 22500297
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionNippon Medical School

Principal Investigator

HAMADA Tomohiro  日本医科大学, 医学部, 助教 (90312058)

Co-Investigator(Kenkyū-buntansha) SAKUMA Yasuo  東京医療学院大学, 保健医療学部, 教授 (70094307)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords性分化 / 視索前野性的二型核 / 可視化 / 細胞移動 / エストロゲン / 性差 / 分界条床核
Research Abstract

The sexually dimorphic nucleus in the preoptic area (SDN-POA) is larger in males than in females, however the mechanism of sexual differentiation of this structure remains largely unknown, except that androgen and/or estrogen during perinatal period cause the establishment of male-typical nuclei. We have shown recently that enhanced green fluorescent protein (EGFP) is expressed in the SDN-POA under the control of an estrogen receptor α gene promoter. The present study suggested that neural migration plays a key role in the sexual differentiation of the SDN-POA to visualize the nucleogenesis of the SDN-POA in vivo and in vitro.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (30 results)

All 2013 2012 2011 2010 Other

All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (18 results) Book (1 results) Remarks (4 results)

  • [Journal Article] Estrogen-induced cell signaling in the sexually dimorphic nucleus of the rat preoptic area: potential involvement of cofilin in actin dynamics for cell migration2013

    • Author(s)
      Wada-Kiyama Y, Suzuki C, Hamada T, Rai D, Kiyama R, Kaneda M, Sakuma Y
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 434(2) Issue: 2 Pages: 287-292

    • DOI

      10.1016/j.bbrc.2013.02.117

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 中枢神経における性差科学の現状2011

    • Author(s)
      濱田知宏、石井寛高、佐久間康夫
    • Journal Title

      ファルマシア

      Volume: 47 Pages: 213-217

    • NAID

      110009884904

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of C-terminally and N-terminally truncated estrogen receptor alpha variants in the mouse2011

    • Author(s)
      Ishii H, Shoda Y, Yomogida K, Hamada T, Sakuma Y
    • Journal Title

      Journal of Steroid Biochemistry and Molecular Biology

      Volume: 124(1/2) Issue: 1-2 Pages: 38-46

    • DOI

      10.1016/j.jsbmb.2011.01.003

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] エストロゲン受容体遺伝子プロモータートランスジェニックラットの利用価値2010

    • Author(s)
      濱田知宏
    • Journal Title

      アニテックス

      Volume: 22 Pages: 10-15

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Journal Article] ラット視索前野性的二型核の可視化2010

    • Author(s)
      濱田知宏、佐久間康夫
    • Journal Title

      日本医科大学医学会雑誌

      Volume: 6 Pages: 96-97

    • NAID

      130004471443

    • URL

      http://www.nms.ac.jp/jmanms/

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen receptor α gene promoter 0/B usage in the rat sexually dimorphic nucleus of the preoptic area2010

    • Author(s)
      Hamada T, Sakuma Y
    • Journal Title

      Endocrinology

      Volume: 151(4) Issue: 4 Pages: 1923-1928

    • DOI

      10.1210/en.2009-1022

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen receptor a gene promoter 0/B usage in the rat sexually dimorphic nucleus of the preoptic area.2010

    • Author(s)
      濱田知宏、佐久間康夫
    • Journal Title

      Endocrinology

      Volume: 151 Pages: 1923-1928

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 分界条床核および視索前野性的二型核の性差形成機構を司るエストロゲン受容体発現2013

    • Author(s)
      塩野拓人、濱田知宏、安藤亮、金田誠、佐久間康夫
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船堀
    • Year and Date
      2013-03-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 視索前野性的二型核および分界条床核における性分化機構の可視化2012

    • Author(s)
      濱田知宏、安藤亮、藤掛雅博、小桧山哲平、佐久間康夫
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2012-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 視索前野性的二型核および分界条床核における性差形成過程の可視化2012

    • Author(s)
      濱田知宏、佐久間康夫
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野県松本文化会館
    • Year and Date
      2012-03-31
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] エストロゲン受容体遺伝子プロモータートランスジェニックラットを用いた分界条床核および視索前野性的二型核の発達過程2012

    • Author(s)
      安藤亮、濱田知宏、佐久間康夫
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野県松本文化会館
    • Year and Date
      2012-03-31
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 思春期の性腺ステロイドによって性指向性回路が形成される2012

    • Author(s)
      小桧山哲平、濱田知宏、佐久間康夫
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野県松本文化会館
    • Year and Date
      2012-03-31
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] エストロゲン受容体遺伝子プロモータートランスジェニックラットにおける分界条床核主部の可視化2012

    • Author(s)
      藤掛雅博、濱田知宏、佐久間康夫
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野県松本文化会館
    • Year and Date
      2012-03-31
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] ラット脳の視索前野性的二型核における臨界期のアクチン・ダイナミクス2012

    • Author(s)
      木山裕子、鈴木千晶、濱田知宏、木山亮一、佐久間康夫
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野県松本文化会館
    • Year and Date
      2012-03-31
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト、マウス及びラットにおけるC末端欠損型エストロゲン受容体αの同定2012

    • Author(s)
      石井寛高、棟朝亜理紗、濱田知宏、佐久間康夫
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野県松本文化会館
    • Year and Date
      2012-03-31
    • Related Report
      2012 Final Research Report
  • [Presentation] 脳の性分化におけるエストロゲンの細胞移動調節2011

    • Author(s)
      濱田知宏
    • Organizer
      第17回「性と生殖」公開シンポジウム(招待講演)
    • Place of Presentation
      早稲田大学井深ホール
    • Year and Date
      2011-12-04
    • Related Report
      2012 Final Research Report
  • [Presentation] 脳の性分化におけるエストロゲンの細胞移動調節2011

    • Author(s)
      濱田知宏
    • Organizer
      第17回「性と生殖」公開シンポジウム
    • Place of Presentation
      早稲田大学井深ホール(招待講演)
    • Year and Date
      2011-12-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 視索前野性的二型核の性分化機構には細胞移動が重要である2010

    • Author(s)
      濱田知宏、佐久間康夫
    • Organizer
      第25回日本下垂体研究会
    • Place of Presentation
      愛知県伊良湖ガーデンホテル
    • Year and Date
      2010-08-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 視索前野性的二型核の性分化機構には細胞移動が重要である2010

    • Author(s)
      濱田知宏、佐久間康夫
    • Organizer
      第25回日本下垂体研究会
    • Place of Presentation
      伊良湖ガーデンホテル(愛知県田原市)
    • Year and Date
      2010-08-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cell specific usage of an estrogen receptor α gene promoter in the sexually dimorphic nucleus of the rat preoptic area.2010

    • Author(s)
      Hamada T, Ishii H, Orikasa C, Sakuma Y
    • Organizer
      The 14th Annual Meeting of the Society for Behaviral Neuroendocrinology
    • Place of Presentation
      Hilton, Toronto, CANADA
    • Year and Date
      2010-07-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Cell specific usage of an estrogen receptor a gene promoter in the sexually dimorphic nucleus of the rat preoptic area2010

    • Author(s)
      T.Hamada, H.Ishii, C.Orikasa, Y.Sakuma
    • Organizer
      The 14th Annual Meeting of the Societyfor Behaviral Neuroendocrinology
    • Place of Presentation
      Hilton Toronto, Canada
    • Year and Date
      2010-07-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 視索前野性的二型核の性分化機構には細胞移動が重要である2010

    • Author(s)
      濱田知宏、佐久間康夫
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      いわて県民情報交流センター
    • Year and Date
      2010-05-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 視索前野性的二型核の性分化機構には細胞移動が重要である2010

    • Author(s)
      濱田知宏、佐久間康夫
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      いわて県民情報交流センター(岩手県盛岡市)
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 視索前野性的二型核および分界条床核における性分化機構の可視化

    • Author(s)
      濱田知宏、安藤亮、藤掛雅博、小桧山哲平、佐久間康夫
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] 分界条床核および視索前野性的二型核の性差形成機構を司るエストロゲン受容体発現

    • Author(s)
      塩野拓人、濱田知宏、安藤亮、金田誠、佐久間康夫
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船堀
    • Related Report
      2012 Annual Research Report
  • [Book] カラー図解症状の基礎からわかる病態生理第2版2011

    • Author(s)
      濱田知宏、佐久間康夫
    • Publisher
      メディカル・サイエンス・インターナショナル
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.h-ic.bb4u.ne.jp/~seiri/

    • Related Report
      2012 Final Research Report
  • [Remarks] 日本医科大学システム生理学分野

    • URL

      http://www.h-ic.bb4u.ne.jp/~seiri/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.h-ic.bb4u.ne.jp/~seiri/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.nms.ac.jp/nms/seiri1/

    • Related Report
      2010 Annual Research Report

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Published: 2010-11-30   Modified: 2019-07-29  

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