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Mitochondrial dynamics in injured axons

Research Project

Project/Area Number 22500314
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionNagoya University (2011-2012)
Osaka City University (2010)

Principal Investigator

KIRYU Sumiko (SEO Sumiko)  名古屋大学, 大学院・医学系研究科, 准教授 (70311529)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords神経損傷 / 神経再生 / 神経変性 / ATF3 / ミトコンドリア / 軸索輸送 / BACトランスジェニックマウス / 大腸菌人工染色体(BAC) / トランスジェニックマウス / 組織特異性 / BAC(大腸菌人工染色体)
Research Abstract

This study focused on mitochondria and attempted to elucidate mitochondrial dynamics in injured axons. For this purpose, we generated BAC transgenic mice to label mitochondria specificallyin injured neurons. The mice showed that mitochondria in the cell body were fragmented in responseto nerve injury and transported to axonal terminal, suggesting that the change is an adaptive response for nerve regeneration.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (21 results)

All 2013 2012 2011 2010 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (10 results) Remarks (1 results)

  • [Journal Article] Expression analysis of the regenerating gene (Reg) family members Reg-IIIβand Reg-IIIγin the mouse during development2012

    • Author(s)
      Matsumoto S, Konishi H, Maeda R, Kiryu-Seo S, Kiyama H
    • Journal Title

      J Comp Nuerol

      Volume: 520 Issue: 3 Pages: 479-494

    • DOI

      10.1002/cne.22705

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The nuclear events guiding successful nerve regeneration2011

    • Author(s)
      Kiryu-Seo S, Kiyama H
    • Journal Title

      Front Mol Neurosci

      Volume: 4 Pages: 53-53

    • DOI

      10.3389/fnmol.2011.00053

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cleavage of neuregulin-1 by BACE1 or ADAM10 produces differential effects on myelination2011

    • Author(s)
      Luo X, Prior M, He W, Hu X, Tang X, Sheng W, Yadav S, Kiryu-Seo S, Miller R, Trapp B, Yan R
    • Journal Title

      J Biol Chem

      Volume: 286 Issue: 27 Pages: 23967-23964

    • DOI

      10.1074/jbc.m111.251538

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myelination and axonal electrical activity modulate the distribution and motility of mitochondria at CNS nodes of Ranvier.2011

    • Author(s)
      Ohno N, Kidd G, Mahad D, Kiryu-Seo S, Avishai A, Komuro H, Trapp BD
    • Journal Title

      J Neurosci

      Volume: 31 Pages: 7249-7528

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis on expression of the regenerating gene (Reg) family members Reg-IIIβ and Reg-IIIγ in the mouse during development2011

    • Author(s)
      Matsumoto S, Konishi H Maeda R, Kiryu-Seo S, Kiyama H
    • Journal Title

      J comparative Neurol

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Damage-induced neuronal endopeptidase is critical for presynaptic formation of neuro-muscular junctions2010

    • Author(s)
      Nagata K, Kiryu-Seo S, Maeda M, Yoshida K, Morita T, Kiyama H.
    • Journal Title

      J Neurosci

      Volume: 30 Issue: 20 Pages: 6954-6962

    • DOI

      10.1523/jneurosci.4521-09.2010

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Demyelination increases axonal stationary mitochondrial size and the speed of axonal mitochondrial transport2010

    • Author(s)
      Kiryu-Seo S, Ohno N, Kidd GJ, Komuro H, Trapp BD
    • Journal Title

      J Neurosci

      Volume: 30 Pages: 6658-6666

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular characterization and expression of the low-density lipoprotein receptor-related protein-10, a new member of the LDLR gene family2010

    • Author(s)
      Jeong YH, Ishikawa K, Someya Y, Hosoda A, Yoshimi T, Yokoyama C, Kiryu-Seo S, Kang MJ, Tchibana T, Kiyama H, Fukumura T, Kim DH, Saeki S
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 391 Issue: 1 Pages: 110-115

    • DOI

      10.1016/j.bbrc.2009.12.033

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Demyelination increases axonal stationary mitochondrial size and the speed of axonal mitochondrial transport.2010

    • Author(s)
      Kiryu-Seo S, Ohno N, Kidd GJ, Komuro H, Trapp BD.
    • Journal Title

      J Neurosci.

      Volume: 30 Pages: 6658-6666

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Damage-induced neuronal endopeptidase is critical for presynaptic formation of neuromuscular junctions.2010

    • Author(s)
      Nagata K, Kiryu-Seo S, Maeda M Yoshida K, Morita T, Kiyama H.
    • Journal Title

      J Neurosci.

      Volume: 30 Pages: 6954-6962

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 「損傷神経細胞の再生能力に関わる分子メカニズム」(シンポジウム)2013

    • Author(s)
      桐生寿美子、木山博資
    • Organizer
      第118回日本解剖学会全国学術集会
    • Place of Presentation
      かがわ国際会議場、香川
    • Year and Date
      2013-03-30
    • Related Report
      2012 Final Research Report
  • [Presentation] DINE欠損は軸索-シュワン細胞相互作用に影響を及ぼし軸索ブランチング形成異常を引き起こす(DINE deficiency affects axon-Schwann cell interactions, leading to failure of nerve terminal arborization)2012

    • Author(s)
      桐生寿美子、松本早紀子、木山博資
    • Organizer
      第35回日本神経科学会
    • Place of Presentation
      名古屋国際会議場、名古屋
    • Year and Date
      2012-09-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 脱髄軸索におけるミトコンドリアダイナミクスの変化2011

    • Author(s)
      桐生寿美子、大野伸彦、Grahame J. Kid、小室仁、Bruce D. Trapp
    • Organizer
      第71回日本解剖学会中部支部学術集会
    • Place of Presentation
      名古屋大学、名古屋
    • Year and Date
      2011-10-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 脱髄軸索におけるミトコンドリアダイナミクスの変化2011

    • Author(s)
      桐生寿美子、大野伸彦、Grahame J.Kid、小室仁、Bruce D.Trapp
    • Organizer
      日本解剖学会中部支部学術集会
    • Place of Presentation
      名古屋大学(名古屋)
    • Year and Date
      2011-10-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Demyelination alters axonal stationary mitochondrial size and the speed of axonal mitochondrial transport脱髄による軸索内ミトコンドリアのサイズと輸送速度の変化2010

    • Author(s)
      桐生-瀬尾寿美子、大野伸彦、Grahame J. Kidd、小室仁、Bruce D. Trapp
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸コンベンションセンター、神戸
    • Year and Date
      2010-09-04
    • Related Report
      2012 Final Research Report
  • [Presentation] Demyelination alters axonal stationary mitochondrial size and the speed of axonal mitochondrial transport2010

    • Author(s)
      桐生-瀬尾寿美子、大野伸彦、Grahame J.Kidd、小室仁、Bruce D.Trapp
    • Organizer
      Neuro2010
    • Place of Presentation
      兵庫県、神戸コンベンションセンター(神戸)
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脱髄軸索におけるミトコンドリアの動態変化2010

    • Author(s)
      桐生-瀬尾寿美子、大野伸彦、Grahame J. Kidd、小室仁、Bruce D. Trapp
    • Organizer
      第25回神経組織の成長・再生・移植研究会学術集会
    • Place of Presentation
      大阪市立大学、大阪
    • Year and Date
      2010-05-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 脱髄軸索におけるミトコンドリアの動態変化2010

    • Author(s)
      桐生-瀬尾寿美子、大野伸彦、Grahame J.Kidd、小室仁、Bruce D.Trapp
    • Organizer
      神経組織の成長・再生・移植研究会学術集
    • Place of Presentation
      大阪府、大阪市立大学
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] DINE欠損は軸索-シュワン細胞相互作用に影響を及ぼし軸索ブランチング形成異常を引き起こす

    • Author(s)
      桐生寿美子
    • Organizer
      日本神経科学会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] 損傷神経細胞の再生能力に関わる分子メカニズム

    • Author(s)
      桐生寿美子
    • Organizer
      日本解剖学会
    • Place of Presentation
      香川
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.nagoya-u.ac.jp/Anatomy2/

    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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