Peripheral nerve degeneration and regeneration from the viewpoint of neuron-Schwann cell interplay
| Project/Area Number |
22500324
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | 公益財団法人東京都医学総合研究所 (2012)
Tokyo Metropolitan Organization for Medical Research (2010-2011) |
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Principal Investigator |
SANGO Kazunori 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 副参事研究員 (50291943)
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| Co-Investigator(Kenkyū-buntansha) |
WATABE Kazuhiko 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 副参事研究員 (30240477)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 筋 / 末梢神経疾患 / 不死化シュワン細胞株 / 脊髄後根神経節細胞 / PC12細胞 / 共培養 / 髄鞘形成 / 糖尿病性神経障害 / 軸索変性・再生 / 神経栄養因子 |
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| Research Abstract |
By employing cultured adult rat neurons and Schwann cells, we investigated the mechanisms of peripheral nerve degeneration and regeneration. The research suggests that galectin-1 is localized to small diameter dorsal root ganglion (DRG) neurons and Schwann cells and plays a role in GDNF-induced axonal regeneration. Moreover, an immortalized Schwann cell line IFRS1 established from adult Fischer 344 rats retains the fundamental ability to myelinate axons in coculture with DRG neurons and NGF-primed PC12 cells, thereby being a valuable tool for the study of demyelination and remyelination.
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Report
(4 results)
Research Products
(93 results)
