Role of positive emotion on stress responses in adolescent rats
| Project/Area Number |
22500378
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fusional social brain science
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| Research Institution | Foundation for Advancement of International Science |
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Principal Investigator |
HORI Miyo 公益財団法人国際科学振興財団, バイオ研究所, 専任研究員 (90399329)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Kazuo (公財)国際科学振興財団, バイオ研究所, 所長 (70110517)
SAKAMOTO Shigeko (公財)国際科学振興財団, バイオ研究所, 専任研究員 (60419869)
OHNISHI Eriko (公財)国際科学振興財団, バイオ研究所, 専任研究員 (90396284)
OHNISHI Junji 東京家政大学, 東京家政大学, 准教授 (40261276)
ICHITANI Yukio 筑波大学, 人間系 (80176289)
YAMADA Kazuo 筑波大学, 人間系 (30282312)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 幼若期 / 隔離ストレス / 快情動 / Tickling / 情動 / ストレス / 恐怖条件づけ / モリス水迷路 / ドパミン / 遺伝子発現 / Ticling |
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| Research Abstract |
In order to demonstrate that a positive affective state, such as play during adolescence, contributes to reverse the changes caused by isolation stress, we analyzed the effects of tickling through behavioral and biochemical indices in post-weaning isolated rats. Tickling stimulation, resembles the rough-and-tumble play behavior in rats, triggers the dopamine release in the nucleus accumbens. Additionally, the tickling could modulate fear-related behavior and sympatho-adrenal response, and recovered the behavioral changes, that were caused by isolated rearing. In conclusion, positive emotion alters directly and/or indirectly neuronal circuitry and behaviors through the play in adolescence.
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Report
(5 results)
Research Products
(29 results)
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[Journal Article] Tickling stimulation causes the up-regulation of the kallikrein family in the submandibular gland of the rat2013
Author(s)
Yamamuro T, Hori M, Nakagawa Y, Hayashi T, Sakamoto S, Ohnishi J, Takeuchi S, Mihara Y, Shiga T, Murakami K, Urayama O
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Journal Title
Behav Brain Res
Volume: 236(1)
Issue: 1
Pages: 236-243
DOI
Related Report
Peer Reviewed
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