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The mechanism of loss of Erc gene ameliorates renal carcinogenesis and modulates integrin related pathway

Research Project

Project/Area Number 22500389
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory animal science
Research InstitutionJuntendo University

Principal Investigator

ZHANG Danqing  順天堂大学, 医学部, 助教 (40296877)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Toshiyuki  順天堂大学, 医学部, 准教授 (40260070)
HINO Okio  順天堂大学, 医学部, 教授 (90127910)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsErc/mesothelin / Tsc2遺伝子 / GPIアンカー蛋白 / ノックアウトマウス / シグナル伝達
Research Abstract

To investigate the position of Erc/mesothelin in signal pathway, we continue the studies and found that a novel function for Erc in the regulation of cell phenotype through controlling EGF receptor phosphorylation (Tyr1092), integrin β1 recycling and localization to lipid raft via a specific downstream effector pathway.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (23 results)

All 2013 2012 2011 2010 Other

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (8 results) Remarks (1 results)

  • [Journal Article] Tuberin activates and controls the distribution of Rac1 viaassociation with p62 and ubiquitinthrough the mTORC1 signaling pathway2013

    • Author(s)
      Okura H, Kobayashi T, Zhang D, Hino O, et al
    • Journal Title

      Int J Oncol

      Volume: 2 Pages: 5-8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Folliculin regulates cyclin D1 expression through cis-acting elements in the 3' untranslated region of cyclin D1 mRNA2013

    • Author(s)
      Kawai A, Kobayashi T, Hino O
    • Journal Title

      Int J Oncol

      Volume: 42(5) Issue: 5 Pages: 1597-604

    • DOI

      10.3892/ijo.2013.1862

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] TSC1 controls distribution of actin fibers through its effect on function of Rho family of small GTPases and regulates cell migration and polarity2013

    • Author(s)
      Ohsawa M, Kobayashi T, Hino O, et al
    • Journal Title

      PLoS One

      Volume: 8(1) Issue: 1 Pages: e54503-e54503

    • DOI

      10.1371/journal.pone.0054503

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fenton Reaction Induced Cancer in Wild Type Rats Recapitulates Genomic Alterations Observed in Human Cancer2012

    • Author(s)
      Liu Y, Izumiya M, Abe K, Ochiai M, Jiang L, Nagai H, Okazaki Y, Murakami H, Sekido Y, Arai E, Kanai Y, Hino O, Takahashi T, Nakagama H, Toyokuni S
    • Journal Title

      PLoS One

      Volume: 7 Issue: 8 Pages: e43403-e43403

    • DOI

      10.1371/journal.pone.0043403

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of the Erc/mesothelin gene ameliorates renal carcinogenesis in Tsc2 knockout mice2011

    • Author(s)
      Zhang D, Kobayashi T, Hino O, et al
    • Journal Title

      Cancer Sci

      Volume: 102(4) Issue: 4 Pages: 720-7

    • DOI

      10.1111/j.1349-7006.2011.01846.x

    • NAID

      10029291977

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of the Erc/mesothelin gene ameliorates renal cazcinogenesis in Tsc2 knockout mice.2011

    • Author(s)
      Zhang D, et al.
    • Journal Title

      Cancer Science

      Volume: (Epubに掲載)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serine 62 is a phosphorylation site in folliculin, the Birt-Hogg-Dubegene product2010

    • Author(s)
      Wang L, Kobayashi T, Zhang D, Hino O, et al
    • Journal Title

      FEBS Lett

      Volume: 584(1) Issue: 1 Pages: 39-43

    • DOI

      10.1016/j.febslet.2009.11.033

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Age dependence of radiation-induced renal cell carcinomas in an Eker rat model2010

    • Author(s)
      T. Kokubo, S. Kakinuma, M. Nishimura, Y. Shimada, et. Al
    • Journal Title

      Cancer Science

      Volume: 101(3) Issue: 3 Pages: 616-623

    • DOI

      10.1111/j.1349-7006.2009.01456.x

    • NAID

      10026589138

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylated hamartin-Hsp70 complex regulates apoptosis via mitochondrial localization2010

    • Author(s)
      Inoue H, Hino O, Kobayashi T, et al
    • Journal Title

      iochem Biophys Res Commun

      Volume: 391(1) Issue: 1 Pages: 1148-53

    • DOI

      10.1016/j.bbrc.2009.12.054

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mesothelin (MSLN) promoter is hypomethylated in malignant mesothelioma, but its expression is not associated with methylation status of the promoter2010

    • Author(s)
      Tan K, Hino O, Fujii H, et al
    • Journal Title

      Hum Pathol

      Volume: 41(9) Issue: 9 Pages: 1330-8

    • DOI

      10.1016/j.humpath.2010.03.002

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of cell death by the secretory form of N-terminal ERC/mesothelin2010

    • Author(s)
      Wang T, Kajino K, Hino O, et al
    • Journal Title

      Int J Mol Med

      Volume: 26(2) Pages: 185-91

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/20596597

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antitumor activity of anti-C-ERC/mesothelin monoclonal antibody in vivo2010

    • Author(s)
      Inami K, Abe M, Hino O, et al
    • Journal Title

      Cancer Sci

      Volume: 101(4) Issue: 4 Pages: 969-74

    • DOI

      10.1111/j.1349-7006.2009.01463.x

    • NAID

      10026591120

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mesothelin (MSLN) promoter is hypomethylated in malignant mesothelioma, but its expression is not associated with methylation status of the promoter.2010

    • Author(s)
      Tan K, et al.
    • Journal Title

      Human Pathology

      Volume: 41 Pages: 1330-8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antitumor activity of anti-C-ERC/mesothelin monoclonal antibody in vivo.2010

    • Author(s)
      Inami K, et al.
    • Journal Title

      Cancer Science

      Volume: 101 Pages: 969-74

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Reduced the phosphorylation of epidermal growth factor (EGF) receptor in Erc-deficient renal tumor cells of Tsc2 KO mice.2012

    • Author(s)
      小橋(張)丹青,ら
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌,札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] Loss of Erc/mesothelin gene reduced the phosphorylation of EGFR and modulates PI3K-Akt pathway in renal tumor cells of Tsc2 KO mice.2012

    • Author(s)
      小橋(張)丹青,ら
    • Organizer
      第26回モロシヌス研究会
    • Place of Presentation
      東京大学弥生講堂,東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] TSC2 positively regulates activity and controls intracellular localization of Rac1 through mTORC1 signaling pathway2011

    • Author(s)
      Okura H, et al
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2011-12-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Loss of Erc/mesothelin gene decreased the growth of renal tumors in Tsc2 KO mice and modulates PI3K-Akt pathway2011

    • Author(s)
      Zhang D, et al
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Enhancement of cell adhesion by Erc/mesothelin through modulation of PI3K-Akt pathway in Tsc2 KO mice renal tumor cells2011

    • Author(s)
      Zhang D, et al
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Loss of Erc/mesothelin gene decreased the growth of renal tumors in Tsc2 knockout mice.2010

    • Author(s)
      Zhang D, et al.
    • Organizer
      The 4th AFLAS Congress Meeting
    • Place of Presentation
      台北国際会議中心(台湾)
    • Year and Date
      2010-11-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Erc/mesothelin gene regulates the growth of renal tumors in Tsc2 KO mice and modulates integrin pathway.2010

    • Author(s)
      Zhang D, et al.
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Loss of Erc gene ameliorates renal carcinogenesis and modulates integrin path-way in Tsc2 KO mouse.2010

    • Author(s)
      Zhang D, et al.
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザ(東京)
    • Year and Date
      2010-04-27
    • Related Report
      2010 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.juntendo.ac.jp/graduate/laboratory/labo/bunshi_byori/index.html

    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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