Point-of-care testing devices with original microfluidic technology and signal amplification method
Project/Area Number |
22500448
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Medical systems
|
Research Institution | The Institute of Physical and Chemical Research |
Principal Investigator |
HOSOKAWA Kazuo 独立行政法人理化学研究所, 前田バイオ工学研究室, 専任研究員 (00373366)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | マイクロチップ / イムノアッセイ / ポイント・オブ・ケア / 疾患マーカー / 臨床検査 / 抗体 |
Research Abstract |
We have developed rapid and sensitive detection methods for disease biomarkers using original microchip and amplification technologies. First, we found that covalent immobilization of antibody to the substrate via dextran matrix is advantageous in terms of sensitivity. Next, we succeeded in detecting three biomarker proteins simultaneously on the microchip. Finally, this method was successfully applied to microRNA detection as well.
|
Report
(4 results)
Research Products
(46 results)