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Development of the ISVSr(irregular shaking and vibration stimulator) which is new physical therapy, and study of the content effective for the prevention of bone fracture by using it.

Research Project

Project/Area Number 22500484
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionFujita Health University

Principal Investigator

YAMADA Kouji  藤田保健衛生大学, 医療科学部, 准教授 (60278306)

Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords骨密度低下 / 骨折予防 / ISVSr / 筋肥大 / 体脂肪 / 骨密度 / マイオカイン / IL-15 / 腰椎 / 骨形態計測 / 骨形成 / 骨吸収 / 振盪 / 振動 / PGC1α / FOXO1 / 大腰筋
Research Abstract

The osteoporosis has a massive impact primarily on trabecular bone as a result of the postmenopausal decline in estrogen. The current study used a model of the decrease in bone density in ovariectomized mice to simulate postmenopausal women. Physical therapy to prevent a decrease in bone density was studied via stimulus in the form of rotation of a platform. Analysis of bone histomorphometry revealed lessening of the decrease in bone density of the lumbar vertebrae, a feat that the stimulus from conventional physical therapy had failed to achieve.
With muscles that function as two-joint muscles such as the psoas major, differences exist in muscular hypertrophy, generation and differentiation between origin and insertion sides.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (20 results)

All 2013 2012 2011 2010 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (13 results)

  • [Journal Article] Stimulus in the form of rotation and shaking of a platform and its effect on the formation of trabecular bone in the lumbar vertebrae of mice2013

    • Author(s)
      Yamada K, Nishii K, Sakai K, Teranishi T
    • Journal Title

      Aging Clin Exp Res

      Volume: 25(6) Pages: 625-32

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stimulus in the form of rotation and shaking of a platform and its effect on the formation of trabecular bone in the lumbar vertebrae of mice.2013

    • Author(s)
      Yamada K, Nishii K, Sakai K, Teranishi T.
    • Journal Title

      Aging Clin Exp Res.

      Volume: 25(6) Pages: 625-632

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Shaking stimuli can retard accelerated decline of bone strength of a mouse model assumed to represent a postmenopausal woman2010

    • Author(s)
      Yamada K, Nishii K, Hida T
    • Journal Title

      J Anal Bio-Sci

      Volume: 33(4) Pages: 355-36

    • NAID

      40019884108

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Shaking stimuli may prevent bone fracture by restraining a bone density decrease gently2010

    • Author(s)
      Yamada K, Nishii K, Sawada H, Ito M, Aizu N, Dohi S Hida T
    • Journal Title

      J Anal Bio-Sci

      Volume: 33(2) Pages: 141-150

    • NAID

      40019883994

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 振盪刺激がマウス大腰筋に及ぼす影響について2010

    • Author(s)
      伊藤正典, 西井一宏, 会津直樹, 土肥さやか, 肥田岳彦, 山田晃司
    • Journal Title

      組織学と特異的タンパク質の発現量からの検討形態・機能

      Volume: 第9巻, 1号 Pages: 3-11

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] shaking stimuli can retard accelerated decline of bone strength of a mouse model assumed to represent a postmenopausal woman.2010

    • Author(s)
      Kouji Yamada, 他2名
    • Journal Title

      J Anal Bio-Sci

      Volume: 33(4) Pages: 355-365

    • NAID

      40019884108

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 振盪刺激がマウス大腰筋に及ぼす影響について組織学と特異的タンパク質の発現量からの検討2010

    • Author(s)
      伊藤正典, 他4名、山田晃司
    • Journal Title

      形態・機能

      Volume: 9(1) Pages: 3-11

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Stimulus in the form of rotation and shaking of a platform and its effect on the formation of trabecular bone in the lumbar vertebrae of mice2013

    • Author(s)
      山田晃司, 西井一宏, 酒井一由, 寺西利生
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 老化に伴う骨密度低下を緩和する刺激装置の開発と検討コ・メディカル形態機能学会2012

    • Author(s)
      山田晃司, 西井一宏, 酒井一由, 肥田岳彦
    • Organizer
      第11回学術集会
    • Place of Presentation
      東京
    • Year and Date
      2012-09-22
    • Related Report
      2013 Final Research Report
  • [Presentation] インナーマッスルを鍛える運動療法により骨強度を保たせる刺激方法の検討2012

    • Author(s)
      山田晃司, 西井一宏, 酒井一由, 寺西利生, 肥田岳彦
    • Organizer
      第85回日本生化学大会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] 老化に伴う骨密度低下が原因の腰椎圧迫骨折を予防する刺激方法の検討2012

    • Author(s)
      山田晃司, 西井一宏, 酒井一由, 澤田浩秀, 肥田岳彦
    • Organizer
      第117回日本解剖学会総会
    • Place of Presentation
      甲府
    • Related Report
      2013 Final Research Report
  • [Presentation] 老化に伴う骨密度低下が原因の腰椎圧迫骨折を予防する刺激方法の検討2012

    • Author(s)
      山田晃司
    • Organizer
      第117回日本解剖学会総会
    • Place of Presentation
      山梨大学
    • Related Report
      2011 Annual Research Report
  • [Presentation] 閉経後女性を想定した老化に伴う骨折を予防するための運動療法の開発2011

    • Author(s)
      山田晃司, 西井一宏, 肥田岳彦
    • Organizer
      第84回日本生化学大会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 老化に伴う腰椎の圧迫骨折を予防する運動療法の開発2011

    • Author(s)
      山田晃司, 西井一宏, 澤田浩秀, 肥田岳彦
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 閉経後女性を想定した老化に伴う骨折を予防するための運動療法の開発2011

    • Author(s)
      山田晃司
    • Organizer
      第84回日本生化学大会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2011 Annual Research Report
  • [Presentation] 老化に伴う腰椎の圧迫骨折を予防する運動療法の開発2011

    • Author(s)
      山田晃司
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] 水平板回転装置による刺激がマウス下肢筋に与える効果の分析2010

    • Author(s)
      山田晃司, 伊藤正典, 西井一宏, 会津直樹, 土肥さやか, 名和史朗, 大川麻樹, 肥田岳彦
    • Organizer
      第115回日本解剖学会総会
    • Place of Presentation
      盛岡
    • Related Report
      2013 Final Research Report
  • [Presentation] 震盪刺激装置を用いた運動療法がマウス下肢帯の筋に与える影響について2010

    • Author(s)
      山田晃司, 伊藤正典, 西井一宏, 肥田岳彦
    • Organizer
      第33回日本分子生物学会年会第83回日本生化学大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] 震盪刺激装置を用いた運動療法がマウス下肢帯の筋に与える影響について2010

    • Author(s)
      山田晃司
    • Organizer
      第33回日本分子生物学会年会第83回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 老化に伴う骨密度低下を緩和する刺激装置の開発と検討

    • Author(s)
      山田晃司
    • Organizer
      コ・メディカル形態機能学会第11回学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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