| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
The present study was performed to evaluate the effects of exercise training and L-arginine administration on the fibrinolysis, blood coagulation and oxidative stress in aged, obese and diabetic rats. The plasminogen activated factor (t-PA and u-PA) significantly increased after exercise training and L-arginine administration. Moreover, thromboxane B2 increased significantly increased after exercise training and L-arginine administration compared with the control rats. The protein oxidation and lipid peroxide significantly decreased, and reduced glutathione (GSH) and glutathione reductase significantly increased after exercise training and L-arginine administration compared with the control rats. This study confirmed that the exercise training and L-arginine administration improved plasminogen activated factor (t-PA and u-PA) and blood coagulation might be due to decrease in oxidative stress in aged, obese and diabetic rats.
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