Effects of exercise training and L-arginine adminstration on fibrinolysis
| Project/Area Number |
22500661
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied health science
|
|---|
| Research Institution | Nagoya Institute of Technology |
|---|
Principal Investigator |
OHKUWA Tetsuo 名古屋工業大学, 工学(系)研究科(研究院), 教授 (80115675)
|
|---|
| Project Period (FY) |
2010-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | アルギニン摂取 / 運動トレーニング / 血液凝固 / 線溶 / 加齢 / 肥満 / 糖尿病 / 酸化ストレス / カルボニル化蛋白 / 過酸化脂質 / L-アルギニン摂取 / ラット / ニトロチロシン / カルボニル化タンパク / 運動 / L-アルギンン摂取 / 血液線溶 / タンパク質酸化 / 還元型グルタチオン / 老化 / 血液の凝固 |
|---|
| Research Abstract |
The present study was performed to evaluate the effects of exercise training and L-arginine administration on the fibrinolysis, blood coagulation and oxidative stress in aged, obese and diabetic rats. The plasminogen activated factor (t-PA and u-PA) significantly increased after exercise training and L-arginine administration. Moreover, thromboxane B2 increased significantly increased after exercise training and L-arginine administration compared with the control rats. The protein oxidation and lipid peroxide significantly decreased, and reduced glutathione (GSH) and glutathione reductase significantly increased after exercise training and L-arginine administration compared with the control rats. This study confirmed that the exercise training and L-arginine administration improved plasminogen activated factor (t-PA and u-PA) and blood coagulation might be due to decrease in oxidative stress in aged, obese and diabetic rats.
|
Report
(5 results)
Research Products
(17 results)
