| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
By using ODS rats having no ability of vitamin C biosynthesis as a human model, the vitamin C dynamics in the brain and its role on the neural cells were evaluated. In the vitamin C-deficient group which mimics the physiological state of aging and oxidative stress, the levels of vitamin C in the serum and peripheral tissues significantly decreased, whereas that in the brain only tended to decrease. This indicates that vitamin C in the brain is retained by the specific mechanism distinct from that in other tissues. Vitamin C is proved to have both a promotion effect on the neural differentiation of PC12 cells and a protection effect on the oxidative stress -induced cell damage. Taken together, it is clearly demonstrated that vitamin C is an essential nutritional factor for regenerating and protecting the neural cells from the aging and oxidative stresses.
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