Identification of microRNA and non-coding RNA regulating the oncogenesis and the progression of colorectal cancers

• Project/Area Number: 22501015
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Kyushu University
• Principal Investigator: SHIBATA Kohei 九州大学, 大学病院, 准教授 (50363560)
• Co-Investigator(Kenkyū-buntansha): MAEDA Toyoki 九州大学, 大学病院, 准教授 (30264112) ; 三森 功士 九州大学, 生体防御医学研究所, 准教授 (50322748)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: がん遺伝子 / ncRNA / 8q24 / PICT1 / 19q13 / mTOR / XIST / 染色体再構成 / lincRNA / 大腸癌 / 癌幹細胞 / 癌関連遺伝子多型 / マイクロアレイ / laser microdissection / aCGH / HOTAIR

Research Abstract

We have focused on novel non-coding RNAs being associated with the oncogenesis and progression of CRC. We applied our established database (aCGH, Gene Expression array, SNP array) to identify the significant molecule by using of the in silico analysis. As a result, we have eventually disclosed three findings;
1) Down-regulation of miR-144 leads to poor prognosis of CRC patients via activation of the mTOR signaling pathway.
2) Expressions of several miRs reflects genomic alterations in colorectal cancer cells. Simultaneous changes of cluster miRs originated form genomic alteration can lead to crucial difference of protein regulation mechanisms continuously, and to influence cancer progression.
3) We demonstrated that G/T rs6983267 allelic variants differently affect lincRNA expression in response to Wnt signaling, and identified MYC as a lincRNA target. Our work suggests a new mechanism for the different CRC risk in subjects carrying the rs6983267 variations.
By grace of the grant, we identified important ncRNA as a candidate clinical marker, and disclosed a new basic oncogenic mechanism in CRC.

Research Products

• [Journal Article] Ability of a convolutional neural network to differentiate between mouse and human cell lines and their radioresistant clones using microscopic images. (2019)
  • Author(s): Toratani, M., Konno, M., Asai. A., Koseki, J., Kawamoto, K., Tamari, K., Li, Z., Sakai, D., Kudo, T., Satoh, T., Sato, K., Motooka, D., Okuzaki, D., Doki, Y., Mori, M., Ogawa, K., Ishii, H.
  • Journal Title: Cancer Res Volume: 72(16) Pages: 1283-1295
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Laparoscopic surgery minimizes the surgical manipulation of isolated tumor cells leading to decreased metastasis compared to open surgery for colorectal cancer (2013)
  • Author(s): Akiyoshi S, Mimori K, Sudo T, Tanaka F, Shibata K, Mori M
  • Journal Title: Surg Today Volume: 43(1) Pages: 20-5
  • NAID: 10031167959
• [Journal Article] Clinical significance of the expression of long non-coding RNA HOTAIR in primary hepatocellular carcinoma (2013)
  • Author(s): Ishibashi M, Kogo R, Shibata K,Sawada G, Takahashi Y, Kurashige J, Akiyoshi S, Sasaki S, Iwaya T, Sudo T, Sugimachi K, Mimori K, Wakabayashi G, Mori M
  • Journal Title: Oncol Rep Volume: 29(3) Pages: 946-50
• [Journal Article] Plastin3 is a novel marker for circulating tumor cells undergoing the epithelial-mesenchymal transition and is associated with colorectal cancer prognosis (2013)
  • Author(s): Yokobori T, Iinuma H, Shimamura T, Imoto S, Sugimachi K, Ishii H, Iwatsuki M, Ota D, Ohkuma M, Iwaya T, Nishida N, Kogo R, Sudo T, Tanaka F, Shibata K, Toh H, Sato T, Barnard GF, Fukagawa T, Yamamoto S, Nakanishi H, Sasaki S, Miyano S, Watanabe T, Kuwano
  • Journal Title: Cancer Res Volume: 73(7) Pages: 2059-69
• [Journal Article] Clinical Significance of PICT1 in Patients of Hepatocellular Carcinoma with Wild-Type TP53 (2013)
  • Author(s): Ishibashi M, Kogo R, Shibata K, Ueo H, Uchi R, Matsumura T, Takano Y, Sawada G, Takahashi Y, Mima K, Kurashige J, Akiyoshi S, Iwaya T, Eguchi H, Sudo T, Sugimachi K, Suzuki A, Wakabayashi G, Mori M, Mimori K
  • Journal Title: Ann Surg Oncol
• [Journal Article] Clinical Significance of PICT1 in Patients of Hepatocellular Carcinoma with Wild-Type TP53. (2013)
  • Author(s): Ishibashi M
  • Journal Title: Ann Surg Oncol. Volume: (未定)
  • Peer Reviewed
• [Journal Article] The rs6983267 SNP Is Associated with MYC Transcription Efficiency Which Promotes Progression and Worsens Prognosis of Colorectal Cancer. (2013)
  • Author(s): Takatsuno Y
  • Journal Title: Ann Surg Oncol. Volume: 20 Pages: 1395-1402
  • DOI: 10.1245/s10434-012-2657-z
  • Peer Reviewed
• [Journal Article] Review: Single nucleotide polymorphisms associated with the oncogenesis of colorectal cancer (2012)
  • Author(s): Mimori K, Tanaka F, Shibata K, Mori M
  • Journal Title: Surg Today Volume: 42(3) Pages: 215-9
  • NAID: 10030231011
• [Journal Article] Down-regulation of miR-125a-3p in human gastric cancer and its clinicopathological significance (2012)
  • Author(s): Hashiguchi Y, Nishida N, Mimori K, Sudo T, Tanaka F, Shibata K, Ishii H, Mochizuki H, Hase K, Doki Y, Mori M
  • Journal Title: Int J Oncol Volume: 40(5) Pages: 1477-82
• [Journal Article] MicroRNA-10b is a prognostic indicator in colorectal cancer and confers resistance to the chemotherapeutic agent 5-fluorouracil in colorectal cancer cells (2012)
  • Author(s): Nishida N, Yamashita S, Mimori K, Sudo T, Tanaka F, Shibata K, Yamamoto H, Ishii H, Doki Y, Mori M
  • Journal Title: Ann Surg Oncol Volume: 19(9) Pages: 3065-71
• [Journal Article] Microarray analysis of colorectal cancer stromal tissue reveals upregulation of two oncogenic miRNA clusters (2012)
  • Author(s): Nishida N, Nagahara M, Sato T, Mimori K, Sudo T, Tanaka F, Shibata K, Ishii H, Sugihara K, Doki Y, Mori M
  • Journal Title: Clin Cancer Res Volume: 18(11) Pages: 3054-70
• [Journal Article] MicroRNA-372 is associated with poor prognosis in colorectal cancer (2012)
  • Author(s): Yamashita S, Yamamoto H, Mimori K, Nishida N, Takahashi H, Haraguchi N, Tanaka F, Shibata K, Sekimoto M, Ishii H, Doki Y, Mori M
  • Journal Title: Oncology Volume: 82(4) Pages: 205-12
• [Journal Article] Expression of Mesenchymal Markers Vimentin and Fibronectin: The Clinical Significance in Esophageal Squamous Cell Carcinoma (2012)
  • Author(s): Sudo T, Iwaya T, Nishida N, Sawada G, Takahashi Y, Ishibashi M, Shibata K,Fujita H, Shirouzu K, Mori M, Mimori K
  • Journal Title: Ann Surg Oncol
• [Journal Article] Downregulation of miR-144 is associated with colorectal cancer progression via activation of mTOR signaling pathway (2012)
  • Author(s): Iwaya T, Yokobori T, Nishida N, Kogo R, Sudo T, Tanaka F, Shibata K, Sawada G, Takahashi Y, Ishibashi M, Wakabayashi G, Mori M, Mimori K
  • Journal Title: Carcinogenesis Volume: 33(12) Pages: 2391-7
• [Journal Article] Cancer susceptibility and embryonic lethality in Mob1a/1b double - mutant mice (2012)
  • Author(s): Nishio M.
  • Journal Title: JOURNAL OF CLINICAL INVESTIGATION Volume: 122 Pages: 4505-18
  • DOI: 10.1172/jci63735
  • Peer Reviewed
• [Journal Article] Downregulation of miR-144 is associated with colorectal cancer progression via activation of mTOR signaling pathway. (2012)
  • Author(s): Iwaya T
  • Journal Title: Carcinogenesis Volume: 33 Pages: 179-517
  • DOI: 10.1093/carcin/bgs288
  • Peer Reviewed
• [Journal Article] MicroRNA-10b is a prognostic indicator in colorectal cancer and confers resistance to the chemotherapeutic agent 5-fluorouracil in colorectal cancer cells. (2012)
  • Author(s): Naohiro Nishida, Shinya Yamashita, Koshi Mimori, Tomoya Sudo, Fumiaki Tanaka, Kohei Shibata, Hirofumi Yamamoto, Hideshi Ishii, Yuichiro Doki, Masaki Mori
  • Journal Title: Ann. Surg. Oncol Volume: (Epub) Pages: 10-10
  • DOI: 10.1245/s10434-012-2246-1
  • Peer Reviewed
• [Journal Article] Down-regulation of miR-125a-3p in human gastric cancer and its clinicopathological significance. (2012)
  • Author(s): Yojiro Hashiguchi, Naohiro Nishida, Koshi Mimori, Tomoya Sudo, Fumiaki Tanaka, Kohei Shibata, Hideshi Ishii, Hidetaka Mochizuki, Kazuo Hase, Yuichiro Doki, Masaki Mori
  • Journal Title: Int. J. Oncol Volume: 40(5) Pages: 1477-1482
  • DOI: 10.3892/ijo.2012.1363
  • Peer Reviewed
• [Journal Article] Review: Single nucleotide polymorphisms associated with the oncogenesis of colorectal cancer. (2012)
  • Author(s): Mimori K, Tanaka F, Shibata K, Mori M
  • Journal Title: SURGERY TODAY Volume: 42 Pages: 215-219
  • DOI: 10.1007/s00595-011-0038-z
  • NAID: 10030231011
  • Peer Reviewed
• [Journal Article] FOXC2 is a novel prognostic factor in human esophageal squamous cell carcinoma (2011)
  • Author(s): Nishida N, Mimori K, Yokobori T, Sudo T, Tanaka F, Shibata K, Ishii H, Doki Y, Mori M
  • Journal Title: Ann Surg Oncol Volume: 18(2) Pages: 535-42
• [Journal Article] MicroRNA-125a-5p is an independent prognostic factor in gastric cancer and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab (2011)
  • Author(s): Nishida N, Mimori K, Fabbri M, Yokobori T, Sudo T, Tanaka F, Shibata K, Ishii H, Doki Y, Mori M
  • Journal Title: Clin Cancer Res Volume: 17(9) Pages: 2725-33
• [Journal Article] MicroRNA miR-125b is a prognostic marker in human colorectal cancer (2011)
  • Author(s): Nishida N, Yokobori T, Mimori K, Sudo T, Tanaka F, Shibata K, Ishii H, Doki Y, Kuwano H, Mori M
  • Journal Title: Int J Oncol Volume: 38(5) Pages: 1437-43
• [Journal Article] Histone deacetylase 1 expression in gastric cancer (2011)
  • Author(s): Sudo T, Mimori K, Nishida N, Kogo R, Iwaya T, Tanaka F, Shibata K, Fujita H, Shirouzu K, Mori M
  • Journal Title: Oncol Rep Volume: 26(4) Pages: 777-82
• [Journal Article] Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers (2011)
  • Author(s): Kogo R, Shimamura T, Mimori K, Kawahara K, Imoto S, Sudo T, Tanaka F, Shibata K, Suzuki A, Komune S, Miyano S, Mori M
  • Journal Title: Cancer Res Volume: 71(20) Pages: 6320-6
• [Journal Article] Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers (2011)
  • Author(s): Kogo R, Shimamura T, Mimori K, Kawahara K, Imoto S, Sudo T, Tanaka F, Shibata K, Suzuki A, Komune S, Miyano S, Mori M
  • Journal Title: Cancer Research Volume: 71 Pages: 6320-6
  • DOI: 10.1158/0008-5472.can-11-1021
  • Peer Reviewed
• [Journal Article] FOXC2 is a novel prognostic factor in human esophageal squamous cell carcinoma (2011)
  • Author(s): Nishida N, Mimori K, Yokobori T, Sudo T, Tanaka F, Shibata K, Ishii H, Doki Y, Mori M.'
  • Journal Title: Ann Surg Oncol Volume: 18(2) Pages: 535-42
  • DOI: 10.1245/s10434-010-1274-y
  • Peer Reviewed
• [Journal Article] MicroRNA-125a-5p is an independent prognostic factor in gastric cancer,and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab. (2011)
  • Author(s): Nishida N, Mimori K, Fabbri M, Yokobori T, Sudo T, Tanaka F, Shibata K, Ishii H, Doki Y, Mori M.]
  • Journal Title: Clin Cancer Res Volume: 17(9) Pages: 2725-2733
  • DOI: 10.1158/1078-0432.ccr-10-2132
  • Peer Reviewed
• [Journal Article] Clinical Significance of Circulating Tumor Cells, Including Cancer Stem-Like Cells, in Peripheral Blood for Recurrence and Prognosis in Patients With Dukes' Stage B and C Colorectal Cancer (2011)
  • Author(s): Iinuma, H.Watanabe, T.Mimori, K., et al.
  • Journal Title: J Clin Oncol Pages: 1547-55
  • Peer Reviewed
• [Journal Article] Identification of HLA-A^*0201/-A^*2402-restricted CTL epitope-peptides derived from a novel cancer/testis antigen, MCAK, and induction of a specific antitumor immune response (2011)
  • Author(s): Kawamoto, M.Tanaka, F.Mimori, K., et al.
  • Journal Title: Oncol Rep Volume: 25 Pages: 469-76
  • Peer Reviewed
• [Journal Article] STC2 : a predictive marker for lymph node metastasis in esophageal squamous-cell carcinoma (2011)
  • Author(s): Kita, Y.Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Volume: 18 Pages: 261-72
  • Peer Reviewed
• [Journal Article] The correlation between clinical laboratory data and telomeric status of male patients with metabolic disorders and no clinical history of vascular events (2011)
  • Author(s): Maeda, T.Oyama, J.Higuchi, Y.Koyanagi, M.Sasaki, M.Arima, T.Mimori, K., et al.
  • Journal Title: Aging Male Volume: 14 Pages: 21-6
  • Peer Reviewed
• [Journal Article] The physical ability of Japanese female elderly with cerebrovascular disease correlates with the telomere length and subtelomeric methylation status in their peripheral blood leukocytes (2011)
  • Author(s): Maeda, T.Oyama, J.Higuchi, Y.Nishiyama, Y.Kudo, Y.Yamori, T.Nakazono, T.Arima, T.Mimori, K., et al.
  • Journal Title: Gerontology Volume: 57 Pages: 137-43
  • Peer Reviewed
• [Journal Article] Kinesin 18A expression clinical relevance to colorectal cancer progression (2011)
  • Author(s): Nagahara, M.Nishida, N.Iwatsuki, M.Ishimaru, S.Mimori, K., et al.
  • Journal Title: Int J Cancer Volume: (Epub)
  • Peer Reviewed
• [Journal Article] MicroRNA-125a-5p is an independent prognostic factor in gastric cancer, and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab (2011)
  • Author(s): Nishida, N.Mimori, K., et al.
  • Journal Title: Clin Cancer Res Volume: (Epub)
  • Peer Reviewed
• [Journal Article] Identification of recurrence-related microRNAs in the bone marrow of breast cancer patients (2011)
  • Author(s): Nishida, N.Mimori, K., et al.
  • Journal Title: Int J Oncol Volume: 38 Pages: 955-62
  • Peer Reviewed
• [Journal Article] Significance of Lgr5(+ve) Cancer Stem Cells in the Colon and Rectum (2011)
  • Author(s): Takahashi, H.Ishii, H.Nishida, N.Takemasa, I.Mizushima, T.Ikeda, M.Yokobori, T.Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Volume: 18 Pages: 1166-74
  • Peer Reviewed
• [Journal Article] Hypoxia-inducible Adrenomedullin in Colorectal Cancer (2011)
  • Author(s): Uemura, M.Yamamoto, H.Takemasa, I.Mimori, K., et al.
  • Journal Title: Anticancer Res Volume: 31 Pages: 507-14
  • Peer Reviewed
• [Journal Article] CD13 is a therapeutic target in human liver cancer stem cells. (2010)
  • Author(s): Haraguchi, N.Ishii, H.Mimori, K., et al.
  • Journal Title: J Clin Invest Pages: 3326-9
  • Peer Reviewed
• [Journal Article] Notch pathway as candidate therapeutic target in Her2/Neu/ErbB2 receptor-negative breast tumors (2010)
  • Author(s): Hirose, H.Ishii ; H.Mimor, K., et al.
  • Journal Title: Oncol Rep Volume: 23 Pages: 35-43
  • Peer Reviewed
• [Journal Article] Clinical Significance of Human Kallikrein7 Gene Expression in Colorectal Cancer. (2010)
  • Author(s): Inoue, Y.Yokobori, T.Yokoe, T.Toiyama, Y.Miki, C.Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Pages: 3037-42
  • Peer Reviewed
• [Journal Article] The Clinical Significance of Vimentin-Expressing Gastric Cancer Cells in Bone Marrow (2010)
  • Author(s): Iwatsuki, M.Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Pages: 2516-33
  • Peer Reviewed
• [Journal Article] Overexpression of SUGT1 in human colorectal cancer and its clinicopat hological significance (2010)
  • Author(s): Iwatsuki, M.Mimori, K., et al.
  • Journal Title: Int J Oncol Volume: 36 Pages: 569-75
  • Peer Reviewed
• [Journal Article] Epithelial-mesenchymal transition in cancer development and its clinical significance (2010)
  • Author(s): Iwatsuki, M.Mimori, K., et al.
  • Journal Title: Cancer Sci Volume: 101 Pages: 293-9
  • Peer Reviewed
• [Journal Article] STC2 : A Predictive Marker for Lymph Node Metastasis in Esophageal Squamous-Cell Carcinoma (2010)
  • Author(s): Kita, Y.Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Pages: 261-72
  • Peer Reviewed
• [Journal Article] Expression of C4.4A at the invasive front is a novel prognostic marker for disease recurrence of colorectal cancer (2010)
  • Author(s): Konishi, K.Yamamoto, H.Mimori, K., et al.
  • Journal Title: Cancer Sci Volume: 101 Pages: 2269-77
  • Peer Reviewed
• [Journal Article] FHIT Suppresses Inflammatory Carcinogenic Activity by Inducing Apoptosis in Esophageal Epithelial Cells (2010)
  • Author(s): Mimori, K., et al.
  • Journal Title: J Nucleic Acid Invest Volume: 101 Pages: 2269-77
  • Peer Reviewed
• [Journal Article] Identification of Recurrence-Related microRNAs in the Bone Marrow of Breast Cancer Patients. (2010)
  • Author(s): Mimori, K., et al.
  • Journal Title: Int J Oncol Pages: 955-62
  • Peer Reviewed
• [Journal Article] Serum Matrix-Metalloproteinase-1 is a Bona Fide Prognostic Marker for Colorectal Cancer (2010)
  • Author(s): Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Pages: 3362-9
  • Peer Reviewed
• [Journal Article] Abnormal Expression of PFDN4 in Colorectal Cancer : A Novel Marker for Prognosis (2010)
  • Author(s): Miyoshi, N.Ishii, H.Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Pages: 3030-6
  • Peer Reviewed
• [Journal Article] TDGF1 is a novel predictive marker for metachronous metastasis of colorectal cancer (2010)
  • Author(s): Mimori, K., et al.
  • Journal Title: Int J Oncol Volume: 36 Pages: 563-8
  • Peer Reviewed
• [Journal Article] SCRN1 is a novel marker for prognosis in colorectal cancer (2010)
  • Author(s): Miyoshi, N.Ishii, H.Mimori, K, et al.
  • Journal Title: J Surg Oncol Volume: 101 Pages: 156-9
  • Peer Reviewed
• [Journal Article] TGM2 is a novel marker for prognosis and therapeutic target in colorectal cancer (2010)
  • Author(s): Miyoshi, N.Ishii, H.Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Volume: 17 Pages: 967-72
  • Peer Reviewed
• [Journal Article] ATP11A is a novel predictive marker for metachronous metastasis of colorctal cancer (2010)
  • Author(s): Miyoshi, N.Ishii, H.Mimori, K., et al.
  • Journal Title: Oncol Rep Volume: 23 Pages: 505-10
  • Peer Reviewed
• [Journal Article] Defined factors induce reprogramming of gastrointestinal cancer cells (2010)
  • Author(s): Miyoshi, N.Ishii, H.Mimori, K., et al.
  • Journal Title: Proc Natl Acad Sci U S A Volume: 107 Pages: 40-5
  • Peer Reviewed
• [Journal Article] Clinicopathological and prognostic significance of PDCD4 and microRNA-21 in human gastric cancer (2010)
  • Author(s): Miyoshi, N.Ishii, H.Mimori, K., et al.
  • Journal Title: Int J Oncol Volume: 36 Pages: 1089-95
  • Peer Reviewed
• [Journal Article] Correlated expression of CD47 and SIRPA in bone marrow and in peripheral blood predicts recurrence in breast cancer patients (2010)
  • Author(s): Nagahara, M.Mimori, K., et al.
  • Journal Title: Clin Cancer Res Volume: 16 Pages: 4625-35
  • Peer Reviewed
• [Journal Article] FOXC2 is a Novel Prognostic Factor in Human Esophageal Squamous Cell Carcinoma (2010)
  • Author(s): Nishida, N.Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Pages: 535-42
  • Peer Reviewed
• [Journal Article] FANCD2 mRNA overexpression is a bona fide indicator of lymph node metastasis in human colorectal cancer (2010)
  • Author(s): Ozawa, H.Iwatsuki, M.Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Volume: 17 Pages: 2341-8
  • Peer Reviewed
• [Journal Article] Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles (2010)
  • Author(s): Tanaka, F.Yamamoto, K.Suzuki, S.Inoue, H.Tsurumaru, M.Kajiyama, Y.Kato, H.Igaki, H.Furuta, K.Fujita, H.Tanaka, T.Tanaka, Y.Kawashima, Y.Natsugoe, S.Setoyama, T.Tokudome, S.Mimori, K., et al.
  • Journal Title: Gut Pages: 1457-64
  • Peer Reviewed
• [Journal Article] Clinical significance of ASB9 in human colorectal cancer (2010)
  • Author(s): Tokuoka, M.Miyoshi, N.Hitora, T.Mimori, K., et al.
  • Journal Title: Int J Oncol Volume: 37 Pages: 1105-11
  • Peer Reviewed
• [Journal Article] Jumonji domain containing 1A is a novel prognostic marker for colorectal cancer : in vivo identification from hypoxic tumor cells (2010)
  • Author(s): Uemura, M.Yamamoto, H.Takemasa, I.Mimori, K., et al.
  • Journal Title: Clin Cancer Res Volume: 16 Pages: 4636-46
  • Peer Reviewed
• [Journal Article] Clinical Significance of Stanniocalcin 2 as a Prognostic Marker in Gastric Cancer (2010)
  • Author(s): Yokobori, T.Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Pages: 2601-7
  • Peer Reviewed
• [Presentation] miR-144によるmTOR制御と大腸癌の予後 (2011)
  • Author(s): 柴田浩平、三森功士、石丸神矢、西田尚弘、岩谷岳、主藤朝也、田中文明、森正樹、北野正剛
  • Organizer: 第110回日本外科学会
  • Place of Presentation: (紙面開催)
  • Year and Date: 2011-05-26
• [Presentation] 大腸癌間質におけるマイクロRNA-遺伝子pathwayの包括的解析 (2011)
  • Author(s): 西田尚弘、永原誠、三森功士、古後龍之介、秋吉清百合、横堀武彦、石丸神矢、石川健二、主藤朝也、田中文明、柴田浩平、森 正 樹
  • Organizer: 第73回大腸癌研究会
  • Place of Presentation: 奄美大島
• [Presentation] 新規癌特異遺伝子MCAK癌抗原ペプチド同定と癌特異的免疫治療への応用 (2011)
  • Author(s): 田中文明、川本恵、主藤朝也、柴田浩平、三森功士、森正樹
  • Organizer: 第32回癌免疫外科研究会
  • Place of Presentation: 和歌山
• [Presentation] miR-144によるmTOR制御と大腸癌の予後 (2011)
  • Author(s): 岩谷岳、横堀武彦、三森功士、主藤朝也、田中文明、柴田浩平、石丸神矢、古後龍之介、西田尚弘、森正樹
  • Organizer: 第111回日本外科学会
  • Place of Presentation: 紙上開催
• [Presentation] 大腸癌間質におけるマイクロRNA-遺伝子pathwayの包括的解析 (2011)
  • Author(s): 岩谷岳、主藤朝也、田中文明、柴田浩平、石井秀始、森正樹
  • Organizer: 第20回日本がん転移学会
  • Place of Presentation: 浜松
• [Presentation] 大腸癌におけるmiR-144発現とmTOR制御に関する検討 (2011)
  • Author(s): 岩谷岳、横堀武彦、三森功士、西田尚弘、古後龍之介、石丸神矢、主藤朝也、田中文明、柴田浩平、森 正 樹
  • Organizer: 第20回日本がん転移学会
  • Place of Presentation: 浜松
• [Presentation] SNPにより発現制御を受けるmiRNA,miR-146aの胃癌における解析 (2011)
  • Author(s): 古後龍之介、三森功士、西田尚弘、岩谷岳、主藤朝也、柴田浩平、田中文明、小宗静男、森正樹
  • Organizer: 第20回日本がん転移学会
  • Place of Presentation: 浜松
• [Presentation] 大腸癌細胞における発現およびゲノムCGH プロファイルを用いた8q24多型に関連した癌進展機構の解明 (2011)
  • Author(s): 三森功士、高角康志、井上裕、岩谷岳、石丸神矢、主藤朝也、田中文明、柴田浩平、杉原健一、森正樹
  • Organizer: 第66回日本消化器外科学会
  • Place of Presentation: 名古屋
• [Presentation] 胃癌原発巣・骨髄におけるhistone family 遺伝子発現の検討 (2011)
  • Author(s): 岩谷岳、三森功士、田中文明、柴田浩平、石丸神矢、西田尚弘、古後龍之介、主藤朝也、若林剛、森正樹
  • Organizer: 第66回日本消化器外科学会
  • Place of Presentation: 名古屋
• [Presentation] 副乳頭近傍のIPMNに対して、十二指腸・胆管温存膵頭部切除を施行した1例 (2011)
  • Author(s): 柴田浩平、西田尚弘、石丸神矢、岩谷岳、主藤朝也、田中文明、三森功士
  • Organizer: 第66回日本消化器外科学会
  • Place of Presentation: 名古屋
• [Presentation] 胃癌におけるマイクロRNAmiR-125aの臨床病理学的意義 (2011)
  • Author(s): 西田尚弘、三森功士、古後龍之介、石丸神矢、岩谷岳、主藤朝也、田中文明、柴田浩平、石井秀始、森正樹
  • Organizer: 第66回日本消化器外科学会
  • Place of Presentation: 名古屋
• [Presentation] HOTAIRは大腸癌においてPRC2を再標的し、予後不良に関わる新規long ncRNAである (2011)
  • Author(s): 古後龍之介、島村徹平、三森功士、河原康一、井元清哉、主藤朝也、田中文明、柴田浩平、小宗静男、鈴木聡、森正樹
  • Organizer: 第70回日本癌学会
  • Place of Presentation: 名古屋
• [Presentation] 新規癌精巣抗原MCAKからのCTLエピトープの同定とヒト抗腫瘍効果の誘導 (2011)
  • Author(s): 田中文明、川本恵、主藤朝也、柴田浩平、三森功士、森正樹
  • Organizer: 第70回日本癌学会
  • Place of Presentation: 名古屋
• [Presentation] F-boxprotein FBXO31の胃癌における発現低下の重要性 (2011)
  • Author(s): 主藤朝也、三森功士、西田尚弘、古後龍之介、岩谷岳、田中文明、柴田浩平、藤田博正、白水和雄、森正樹
  • Organizer: 第70回日本癌学会
  • Place of Presentation: 名古屋
• [Presentation] 食道扁平上皮癌における17q25.1 TOC locus上の全転写産物解析 (2011)
  • Author(s): 岩谷岳、三森功士、西田尚弘、古後龍之介、柴田浩平、田中文明、主藤朝也、澤田元太、高橋佑典、石橋正久、森正樹
  • Organizer: 第70回日本癌学会
  • Place of Presentation: 名古屋
• [Presentation] 食道癌における転写関連遺伝子FOXC2の臨床病理学的意義 (2011)
  • Author(s): 西田尚弘、三森功士、澤田元太、高橋佑典、古後龍之介、赤木智徳、岩谷岳、主藤朝也、田中文明、柴田浩平、石井秀始、森正樹
  • Organizer: 第70回日本癌学会
  • Place of Presentation: 名古屋
• [Presentation] 個別診療のための大腸発癌および食道発癌ハイリスク因子の同定 (2011)
  • Author(s): 三森功士、田中文明、主藤朝也、柴田浩平
  • Organizer: JDDW2011
  • Place of Presentation: 福岡
• [Presentation] p53制御遺伝子PICT1の消化器癌における発現解析 (2011)
  • Author(s): 古後龍之介、河原康一、三森功士、西田尚弘、岩谷岳、石橋正久、高橋佑典、澤田元太、赤木智徳、甲斐裕一郎、主藤朝也、田中文明、柴田浩平、小宗静男、鈴木聡、森正樹
  • Organizer: 第49回日本癌治療学会
  • Place of Presentation: 名古屋
• [Presentation] 胃癌におけてHER2を制御するマイクロRMAの検討 (2011)
  • Author(s): 西田尚弘、三森功士、主藤朝也、田中文明、柴田浩平、石井秀始、森正樹
  • Organizer: 第49回日本癌治療学会
  • Place of Presentation: 名古屋
• [Presentation] 早期・進行胃がん症例骨髄のWhole transcriptome 解析による比較検討 (2011)
  • Author(s): 岩谷岳、深川剛生、三森功士、西田尚弘、古後龍之介、柴田浩平、田中文明、主藤朝也、赤木智徳、高橋佑典、澤田元太、石橋正久、笹子三津留、森正樹
  • Organizer: 第49回日本癌治療学会
  • Place of Presentation: 名古屋
• [Presentation] 大腸癌におけるゲノムワイド発癌関連多型解析の結果 (2011)
  • Author(s): 高橋佑典、古後龍之介、西田尚弘、赤木智徳、岩谷岳、主藤朝也、柴田浩平、田中文明、三森功士、森正樹
  • Organizer: 第22回消化器癌発生学会
  • Place of Presentation: 佐賀
• [Presentation] 大腸癌細胞のゲノムCGHクラスター解析および発現アレイpathway解析による5-FU適応症例の決定 (2010)
  • Author(s): 三森功士, 他8名
  • Organizer: 第110回日本外科学会定期学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-04-09
• [Presentation] 大腸癌間質におけるmicroRNAの発現意義-microRNA arrayと遺伝子発現arrayの統合解析から- (2010)
  • Author(s): 西田尚弘、永原誠、三森功士、古後龍之介、横堀武彦、石丸神矢、岩谷岳、主藤朝也、田中文明、柴田浩平、杉原健一、森正樹
  • Organizer: 第19回日本がん転移学会
  • Place of Presentation: 金沢
• [Presentation] 大腸癌のゲノムにおけるmicroRNA領域の変異とその臨床学的意義 (2010)
  • Author(s): 石丸神矢、三森功士、田中文明、柴田浩平、主藤朝也、横堀武彦、西田尚弘、古後龍之介、岩谷岳、杉原健一、森正樹
  • Organizer: 第73回大腸癌研究会
  • Place of Presentation: 奄美大島
• [Presentation] 樹状細胞と癌抗原を用いた消化器癌ワクチン治療:癌幹細胞を標的として (2010)
  • Author(s): 田中文明、古後龍之介、石川健二、主藤朝也、三森功士、柴田浩平、森正樹
  • Organizer: 第65回日本消化器外科学会
  • Place of Presentation: 下関