Heterocycle synthesis utilizing ortho-functionalized phenyl isothiocyanates
| Project/Area Number |
22550035
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Tottori University |
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Principal Investigator |
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 有機合成化学 / へテロ環 / ファーマコフォア / イソチオシアナート / ヘテロ環 / 3,1-ベンゾチアジン / 3-アミノピリジン / 臭素―リチウム交換 / イソインドール / アクリジノン / ベンゾナフチリジノン / 4H-3,1-ベンゾチアジン / 1,7-ナフチリジン-2(1H)-チオン / 2H-3,1-ベンゾオキサジン-4-チオン / インドール / イソニトリル / チオカルバモイルインドール / キナゾリンジチオン / ベンゾセレナゾール / ベンズオキサジンチオン / ベンズオキサゼピンチオン / ベンゾチアゼピンチオン / ベンゾチアゾール / 4H-3,1-ベンズオキサジン / ヨウ化水素酸 / トリフルオロ酢酸 / リチウム化 / チオール |
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| Research Abstract |
Twenty three simple methods for the general preparation of heterocyclic derivatives (organic cyclic compounds containing more than one hetero atom, such as N, S or O, in the ring(s)), which are hard or impossible to prepare by previous methods, utilizing ortho-functionalized phenyl isothiocyanates (benzene derivatives having a isothiocyanato: -N=C=S group and a functional (labile) group adjacent to each other of the benzene ring) have been developed. The isothiocyanates can be prepared from readily available starting materials. The products prepared are of highly potential use for creation of new medicines or agricultural medicines.
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Report
(5 results)
Research Products
(58 results)
