Structure and functional analysis of the GCase receptor by x-ray
Project/Area Number |
22570110
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Structural biochemistry
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Research Institution | The University of Tokyo |
Principal Investigator |
OGAWA Haruo 東京大学, 分子細胞生物学研究所, 准教授 (40292726)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 受容体 / ANP / ホルモン / 膜受容体 / 膜蛋白質 / X線結晶構造解析 / X線結晶解析 / 大量発現 |
Research Abstract |
ANP receptor, which belongs to a member of guanylyl cyclase (GCase) receptor family,plays a key role in the regulation of blood pressure and body fluid balance in our body.The mechanisms "how the GCase receptor recognizes hormone" and "how the receptortransmits the hormone-binding signal to its intracellular domain” are still unknown.To elucidate the mechanisms, we performed x-ray crystallography of the ANP receptorextracellular domain complexed with ligands and kinetics experiments of the receptor.
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase2011
Author(s)
Misono, K.S., Philo, J.S., Arakawa, T., Ogata, C.M., Qiu, Y., Ogawa, H., Young, H.S.
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Journal Title
FEBS J
Volume: (印刷中)(掲載確定)
Related Report
Peer Reviewed
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