Mechanism of primitive polarity formation in epithelial cells independent of cell-cell contact
| Project/Area Number |
22570195
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
YONEMURA Shigenobu 独立行政法人理化学研究所, 電子顕微鏡解析室, 室長 (60192811)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 上皮細胞 / 極性 / ミオシン / 細胞外基質 / 上皮極性 / 微小管 / 細胞周期 / 細胞極性 / 細胞間接着装置 / 細胞接着装置 |
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| Research Abstract |
I aimed elucidation of the molecular mechanism of polarity formation of epithelial cells. By knocking down a number of genes known to be involved in polarity formation or in force generation through actomyosin interaction, I confirmed the roles of the known factors. Furthermore, I found that myosin motor activity is important for positioning of the cell-cell junctions according to the polarity. Moreover, positional cues from the ECM are not required for establishment of the epithelial polarity but important for alignment of the polarity of each cell.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] Trichoplein and Aurora A block aberrant primary cilia assembly in proliferating cells2012
Author(s)
Inoko A, Matsuyama M, Goto H, Ohmuro-Matsuyama Y, Hayashi Y, Enomoto M, Ibi M, Urano T, Yonemura S, Kiyono T, Izawa I, Inagaki M
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Journal Title
J Cell Biol.
Volume: 197
Pages: 391-405
Related Report
Peer Reviewed
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[Journal Article] Epithelial cell-intrinsic Notch signaling plays an essential role in the maintenance of gut immune homeostasis2012
Author(s)
Obata Y, Takahashi D, Ebisawa M, Kakiguchi K, Yonemura S, Jinnohara T, Kanaya T, Fujimura Y, Ohmae M, Hase K, Ohno H
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Journal Title
J Immunol.
Volume: 188
Pages: 2427-36
Related Report
Peer Reviewed
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[Journal Article] Self-formation of functional adenohypophysis in three-dimensional culture2011
Author(s)
Suga H, Kadoshima T, Minaguchi M, Ohgushi M, Soen M, Nakano T, Takata N, Wataya T, Muguruma K, Miyoshi H, Yonemura S, Oiso Y, Sasai Y
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Journal Title
Nature
Volume: 480
Pages: 57-62
Related Report
Peer Reviewed
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[Journal Article] Metalloprotease-dependent onset of blood circulation in zebrafish2010
Author(s)
Iida A, Sakaguchi K, Sato K, Sakurai H, Nishimura D, Iwaki A, Takeuchi M, Kobayashi M, Misaki K, Yonemura S, Kawahara A, Sehara-Fujisawa A
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Journal Title
Curr Biol.
Volume: 20
Pages: 1110-6
Related Report
Peer Reviewed
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[Journal Article] Mib-Jag1-Notch signalling regulates patterning and structural roles of the notochord by controlling cell-fate decisions2010
Author(s)
Yamamoto M, Morita R, Mizoguchi T, Matsuo H, Isoda M, Ishitani T, Chitnis AB, Matsumoto K, Crump JG, Hozumi K, Yonemura S, Kawakami K, Itoh M
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Journal Title
Development
Volume: 137
Pages: 2527-37
Related Report
Peer Reviewed
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