A study of controlling splicing for conditional gene expression.
| Project/Area Number |
22580101
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | Tokai University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 遺伝子発現 / 遺伝子発現調節 / スプライシング / RNA 結合タンパク質 / エキソン / イントロン / RNA結合タンパク質 |
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| Research Abstract |
The aim of this study is to control alternative splicing and gene expression as our own purpose. By using nematode C.elegans as model organism, reporter mini-gene with GFP/RFP is constructed. This mini-gene is designed to express GFP/RFP only when alternative splicing is completed as desired. An RNA binding protein which plays an important role to alternative splicing is also investigated.
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Report
(4 results)
Research Products
(15 results)
