Interrelated effects of dietary factors on hepatic fatty acid metabolism

• Project/Area Number: 22580143
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Food science
• Research Institution: Jumonji University
• Principal Investigator: IDE Takashi 十文字学園女子大学, 人間生活学部・食物栄養学科, 教授 (20127971)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 食品機能 / 脂質代謝 / 脂肪酸合成 / 脂肪酸酸化 / 遺伝子発現 / セサミン / 魚油 / n-3脂肪酸 / カルニチン / α-リポ酸 / ゴマリグナン / 脂肪酸酸化活性 / ペルオキシゾーム / 相乗作用

Research Abstract

Combined effects of different food factors affecting lipid metabolism were evaluated using rats as experimental animals.
(1) Low dietary levels of fish oil enhanced physiological activity of sesamin to increase hepatic fatty acid oxidation.
(2)Dietary sesamin and α-lipoic acid reduced hepatic lipogenesis in an additive fashion. However, α-lipoic acid antagonized the stimulating effect of sesamin of fatty acid oxidation through reductions in t carnitine concentration in the liver.
(3)Dietary sesamin and soybean phospholipid reduced hepatic lipogenesis in an additive fashion. Moreover, soybeanphospholipid enhanced the stimulating effect of sesamin of fatty acid oxidation through the increase in carnitine concentration in th

Research Products

• [Journal Article] Combined effect of sesamin and α-lipoic acid on hepatic fatty acid metabolism in rats (2013)
  • Author(s): Ide T, Azechi A, Kitade S, Kunimatsu Y, Suzuki N, Nakajima C
  • Journal Title: Eur J Nutr Volume: 52(3) Issue: 3 Pages: 1015-27
  • DOI: 10.1007/s00394-012-0408-3
  • Peer Reviewed
• [Journal Article] Effects of dietary α-lipoic acid enantiomers on hepatic fatty acid metabolism in rats. (2013)
  • Author(s): Ide T, Azechi A, Suzuki N, Kunimatsu Y, Nakajima C, Kitade S
  • Journal Title: J Funct Foods Volume: 5(1) Issue: 1 Pages: 71-9
  • DOI: 10.1016/j.jff.2012.08.005
  • Peer Reviewed
• [Journal Article] ポリフェノールの有効性の評価--動物実験の役割 (2012)
  • Author(s): 井手隆
  • Journal Title: 日本ポリフェノール学会誌 Volume: 1 Pages: 33-45
  • NAID: 40019792589
• [Journal Article] Fish oil at low dietary levels enhances physiological activity of sesamin to increase hepatic fatty acid oxidation in rats (2012)
  • Author(s): Ide T
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 51 Issue: 3 Pages: 241-247
  • DOI: 10.3164/jcbn.12-38
  • NAID: 130004466689
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Journal Article] Interrelated effects of dihomo-γ-linolenic and arachidonic acids, and sesamin on hepatic fatty acid synthesis and oxidation in rats (2012)
  • Author(s): Ide T, Ono Y, Kawashima H, Kiso Y
  • Journal Title: Br J Nutr Volume: 108(11) Issue: 11 Pages: 1980-93
  • DOI: 10.1017/s0007114512000141
  • Peer Reviewed
• [Journal Article] ポリフェノールの有効性の評価-動物実験の役割 (2012)
  • Author(s): 井手隆
  • Journal Title: 日本ポリフェノール学会誌 Volume: 1 Pages: 33-45
  • NAID: 40019792589
• [Journal Article] Antioxidant Capacities and Total Quercetin Content of Several Species of Polygonaceae in Mongolia (2010)
  • Author(s): Tseye-Oidov O, Mikami I, Watanabe, J, Tsushida T, Demberel B, Kimura T, Ide T
  • Journal Title: Food Science and Technology Research Volume: 16 Issue: 2 Pages: 169-174
  • DOI: 10.3136/fstr.16.169
  • NAID: 10027496448
  • ISSN: 1344-6606, 1881-3984
  • Peer Reviewed
• [Journal Article] Enzymatic-HPLC Method to Analyze <small>D</small>-3-Hydroxybutyric Acid in Rat Serum (2010)
  • Author(s): Ide T
  • Journal Title: Bioscience, Biotechnology, and Biochemistry Volume: 74 Issue: 8 Pages: 1578-1582
  • DOI: 10.1271/bbb.100167
  • NAID: 10027558025
  • ISSN: 0916-8451, 1347-6947
  • Peer Reviewed
• [Journal Article] Enzymatic-HPLC method to analyze D-3-hydroxybutyric acid in rat serum. (2010)
  • Author(s): Ide T.
  • Journal Title: Biosci Biotechnol Biochem. Volume: 74 Pages: 1578-1582
  • NAID: 10027558025
  • Peer Reviewed
• [Presentation] α-リポ酸異性体の脂質代謝調節機能 (2012)
  • Author(s): 北出清夏、畦地彩奈、岡根なつみ、井手隆
  • Organizer: 第66回日本栄養・食糧学会
  • Place of Presentation: 東北大学、仙台
  • Year and Date: 2012-05-19
• [Presentation] 高リグナンゴマの脂質代謝調節機能 (2012)
  • Author(s): 鈴木菜津子、國松瑤子、中島千尋、井手隆
  • Organizer: 第66回日本栄養・食糧学会
  • Place of Presentation: 東北大学、仙台
  • Year and Date: 2012-05-19
• [Presentation] α-リポ酸とセサミンによるラット肝臓の脂肪酸代謝の制御 (2011)
  • Author(s): 井手隆、有田安那、佐々木菜穂
  • Organizer: 第65回日本栄養・食糧学会大会
  • Place of Presentation: お茶の水女子大、東京
  • Year and Date: 2011-05-14
• [Presentation] α-リポ酸とセサミンによるラット肝臓の脂肪酸代謝の制御 (2011)
  • Author(s): 井手隆、有田安那、佐々木菜穂
  • Organizer: 第65回日本栄養・食糧学会大会
  • Place of Presentation: お茶の水女子大(東京都)
  • Year and Date: 2011-05-14
• [Presentation] ポリフェノールの有効性の評価:動物実験の役割 (2010)
  • Author(s): 井手隆
  • Organizer: 第4回日本ポリフェノール学会年次大会
  • Place of Presentation: 十文字学園女子大学(新座市)
  • Year and Date: 2010-08-06
• [Presentation] ポリフェノールの有効性の評価:動物実験の役割 (2010)
  • Author(s): 井手隆
  • Organizer: 第4回ポリフェノール研究会
  • Place of Presentation: 十文字学園女子大学(新座市)(招待講演)
  • Year and Date: 2010-08-06
• [Presentation] α-リポ酸によるラット肝臓の薬物代謝関連遺伝子発現変化-DNA マイクロアレイによる解析 (2010)
  • Author(s): 井手隆
  • Organizer: 第64回日本栄養・食糧学会大会
  • Place of Presentation: アスティとくしま、徳島市
  • Year and Date: 2010-05-23
• [Presentation] α-リポ酸によるラット肝臓の薬物代謝関連遺伝子発現変化-DNAマイクロアレイによる解析 (2010)
  • Author(s): 井手隆
  • Organizer: 第64回日本栄養・食糧学会大会
  • Place of Presentation: アスティとくしま(徳島市)
  • Year and Date: 2010-05-23
• [Presentation] 高リグナンゴマの脂質代謝制御機能
  • Author(s): 鈴木菜津子、國松瑤子、中島千尋、井手隆
  • Organizer: 第66回日本栄養・食糧学会
  • Place of Presentation: 東北大学、仙台