Development of general anesthesia method of horse environmentally friendly kind to animals project.

• Project/Area Number: 22580366
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Clinical veterinary science
• Research Institution: Rakuno Gakuen University
• Principal Investigator: YAMASHITA Kazuto 酪農学園大学, 獣医学群, 教授 (60244844)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2010: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
• Keywords: 馬 / 呼吸循環機能 / 全静脈麻酔（TIVA） / 麻酔効果 / 臨床試験 / 獣医麻酔 / 全静脈麻酔 / メデトミジン / ブトルファノール / リドカイン / プロポフォール

Research Abstract

To aim to develop a less cardio-respiratory depression and environmentally-friendly anesthetic protocol, we investigated a total intravenous anesthesia using a drug combination of medetomidine, lidocaine, butorphanol and propofol (MLBP-TIVA) in horses. MLBP-TIVA provided effective general anesthesia and good recovery in horses while preserving cardiovascular function. In addition, MLBP-TIVA is a multi-purpose anesthetic protocol that can be used for field anesthesia and prolonged anesthesia.

Research Products

• [Journal Article] Effects of intermittent positive pressure ventilation on cardiopulmonary function in horses anesthetized with total intravenous anesthesia using a drug combination of medetomidine, lidocaine, butorphanol and propofol (MLBP-TIVA) (2014)
  • Author(s): Ishizuka T, Tamura J, Nagaro T, Sudo K, Itami T, Umar MA, Miyoshi K, Sano T, Yamashita K.
  • Journal Title: Journal of Veterinary Medical Science Volume: 76
  • Peer Reviewed
• [Journal Article] Anesthetic and cardiorespiratory effects of propofol, medetomidine, lidocatine and butorphanol total intravenous anesthesia in horses (2013)
  • Author(s): Ishizuka T, Itami T, Tamura J, Saitoh Y, Saitoh M, Umar MA, Miyoshi K, Yamashita K, Muir WW
  • Journal Title: Journal of Veterinary Medical Science Volume: 75 Pages: 165-172
  • Peer Reviewed
• [Journal Article] Anesthetic and Cardiorespiratory Effects of Propofol, Medetomidine, Lidocaine and Butorphanol Total Intravenous Anesthesia in Horses (2013)
  • Author(s): Ishizuka T, Itami T, Tamura J,Saitoh Y, Saitoh M, Umar MA, Miyoshi K, Yamashita K, Muir WW.
  • Journal Title: Journal of Veterinary Medical Science Volume: 75 Issue: 2 Pages: 165-172
  • DOI: 10.1292/jvms.12-0203
  • NAID: 130001879636
  • ISSN: 0916-7250, 1347-7439
  • Peer Reviewed
• [Presentation] Clinical application of total intravenous anesthesia using a drug combination of medetomidine, lidocaine, butorphanol, and propofol (MLBP-TIVA) in horses (2013)
  • Author(s): T. Ishizuka, R. Noda, J. Tamura, T. Itami, S. Fukui, N. Oyama, K. Kawase, K. Miyoshi, Sano, K. Yamashita
  • Organizer: 3rd Asian Meeting of Animal Medicine Specialty (AMAMS 2013)/3^<rd> Conference of Asian Society of Veterinary Surgery
  • Place of Presentation: IPB International Conference Center, Bogor, Indonesea
  • Year and Date: 2013-12-15
• [Presentation] Clinical application of total intravenous anesthesia using a drug combination of medetomidine, lidocaine, butorphanol, and propofol (MLBP-TIVA) in horses. (2013)
  • Author(s): Ishizuka T, Noda R, Tamura J, Itami T, Fukui S, Oyama N, Kawase K, Miyoshi K, Sano T, Yamashita K
  • Organizer: 3rd Asian Meeting of Animal Medicine Specialty/2nd Conference of Asian Society of Veterinary Surgery
  • Place of Presentation: Bogor, Indonesea
• [Presentation] メデトミジン-リドカイン-ブトルファノール-プロポフォールを用いた 馬の全静脈麻酔法の臨床応用 (2013)
  • Author(s): 野田龍介 石塚友人 田村 純 福井 翔 大山紀彦 川瀬広大 伊丹貴晴 三好健二郎 佐野忠士 山下和人
  • Organizer: 第86回獣医麻酔外科学会
  • Place of Presentation: さいたま市
• [Presentation] Evaluation of cardio- pulmonary effects of total intravenous anesthesia using a drug combination of medetomidine, lidocaine, butorphanol and propofol (MLBP-TIVA) with or without controlled ventilation and effect of positioning in mechanically ventilated horses (2012)
  • Author(s): T. Ishizuka, T. Nagaro, K. Sudo, T. Itami, J. Tamura, S. Fukui, K. Miyoshi, K. Yamashita
  • Organizer: 2^<nd> Conference of Asian Society of Veterinary Surgery
  • Place of Presentation: Nanjing Agricultural University, Nanjing, China
  • Year and Date: 2012-11-23
• [Presentation] Evaluation of cardio- pulmonary effects of total intravenous anesthesia using a drug combination of medetomidine, lidocaine, butorphanol and propofol (MLBP-TIVA) with or without controlled ventilation and effect of positioning in mechanically ventilated horses (2012)
  • Author(s): T. Ishizuka, T.Nagaro, K. Sudo, T. Itami, J. Tamura, S. Fukui, K. Miyoshi, K. Yamashita
  • Organizer: 11^<th> World Congress of Veterinary Anesthesia
  • Place of Presentation: Cape Town International Convention Centre, Cape Town, South Africa
  • Year and Date: 2012-09-22
• [Presentation] Pilot study for evaluating quality of anesthesia and recovery in horses anesthetized with total intravenous anesthesia using a drug combination of medetomidine, lidocaine, butorphanol and propofol (MLBP-TIVA) (2011)
  • Author(s): J. Tamura, M. Saito, Y. Yarita, T. Ishizuka, Itami, K. Miyoshi, K. Yamashita
  • Organizer: 36th Annual Meeting of American College of Veterinary Anesthesiologists
  • Place of Presentation: Gaylord Opryland, Nashville, USA
  • Year and Date: 2011-09-15
• [Presentation] Effects of positioning during anesthesia on cardiovascular function in mechanically ventilated horses anesthetized with total intravenous anesthesia using a drug combination of medetomidine, lidocaine, butorphanol and propofol (MLBP-TIVA) (2011)
  • Author(s): T. Itami, T. Ishizuka, K. Sudo, J. Tamura, K. Miyoshi, K. Yamashita
  • Organizer: 36th Annual Meeting of American College of Veterinary Anesthesiologists
  • Place of Presentation: Gaylord Opryland, Nashville, USA
  • Year and Date: 2011-09-15
• [Presentation] Evaluation of cardiopulmonary effects of total intravenous anesthesia using a drug combination of medetomidine, lidocaine, butorphanol and propofol (MLBP-TIVA) with or without controlled ventilation in horses (2011)
  • Author(s): T. Ishizuka, T. Nagaro, J. Tamura, T. Itami, K. Miyoshi, K. Yamashita
  • Organizer: 36th Annual Meeting of American College of Veterinary Anesthesiologists
  • Place of Presentation: Gaylord Opryland, Nashville, USA
  • Year and Date: 2011-09-15
• [Presentation] Pilot study for evaluating quality of anesthesia and recovery in horses an esthetized with total intravenous anesthesia using a drug combination of medetomidine, lidocaine, butorphanol and propofol (MLBP-TIVA) (2011)
  • Author(s): J.Tamura, M.Saito, Y.Yarita, T.Ishizuka, T.Itami, K.Miyoshi, K.Yamashita
  • Organizer: Annual Meeting of American College of Veterinary Anesthesiologists
  • Place of Presentation: Gaylord Opryland, Nashville, USA
  • Year and Date: 2011-09-15
• [Presentation] Effects of positioning during anesthesia on cardiovascular function in me chanically ventilated horses anesthetized with total intravenous anesthesia using a drug combination of medetomidine, lidocaine, butorphanol and propofol (MLBP-TIVA) (2011)
  • Author(s): T.Itami, T.Ishizuka, K.Sudo, J.Tamura, K.Miyoshi, K.Yamashita
  • Organizer: Annual Meeting of American College of Veterinary Anesthesiologists
  • Place of Presentation: Gaylord Opryland, Nashville, USA
  • Year and Date: 2011-09-15
• [Presentation] Evaluation of cardiopulmonary effects of total intravenous anesthesia using a drug combination of medetomidine, lidocaine, butorphanol and propo fol (MLBP-TIVA) with or without controlled ventilation in horses (2011)
  • Author(s): T.Ishizuka, T.Nagaro, J.Tamura, T.Itami, K.Miyoshi, K.Yamashita
  • Organizer: Annual Meeting of American College of Veterinary Anesthesiologists
  • Place of Presentation: Gaylord Opryland, Nashville, USA
  • Year and Date: 2011-09-15
• [Presentation] Evaluation of anesthetic and cardio-respiratory effects of total intravenous anesthesia using a drug combination of medetomidine, lidocaine, butorphanol, and propofol in horses (2011)
  • Author(s): K. Yamashita, T. Ishizuka, T. Itami, K. Miyoshi
  • Organizer: 2^<nd> Meeting of Asian Society of Veterinary Surgery
  • Place of Presentation: IMPACT Convention Center, Bangkok, Thailand
  • Year and Date: 2011-05-08
• [Presentation] Evaluation of anesthetic and cardio-respiratory effects of total intravenous anesthesia using a drug combination of medetomidine, lidocaine, butorphanol, and propofol in horses (2011)
  • Author(s): K.Yamashita, T.Ishizuka, T.Itami, K.Miyoshi
  • Organizer: 2^<nd> Meeting of Asian Society of Veterinary Surgery
  • Place of Presentation: IMPACT Convention Center, Impact Muang Thong Thani, THAILAND
  • Year and Date: 2011-05-08
• [Presentation] Total intravenous anesthesia using a drug combination of medetomidine, lidocaine, butorphanol, and propofol in horses (2011)
  • Author(s): T. Ishizuka, T. Itami, K. Miyoshi, K. Yamashita
  • Organizer: Preliminary Conference of Asian Society of Veterinary Surgery
  • Place of Presentation: 福岡国際会議場,福岡
  • Year and Date: 2011-01-30
• [Presentation] Total intravenous anesthesia using a drug combination of medetomidine, lidocaine, butorphanol, and propofol in horses (2011)
  • Author(s): T.Ishizuka, T.Itami, K.Miyoshi, K.Yamashita
  • Organizer: 1^<st> Meeting of Asian Society of Veterinary Surgery
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2011-01-30
• [Presentation] メデトミジン-リドカイン-ブトルファノーループロポフォールを用いた馬の全静脈麻酔法 (2010)
  • Author(s): 伊丹貴晴, 石塚友人, 三好健二郎, 山下和人
  • Organizer: 第150回日本獣医学会
  • Place of Presentation: 帯広畜産大学
  • Year and Date: 2010-09-17
• [Presentation] メデトミジン-リドカイン-ブトルファノーループロポフォールを用いた馬の全静脈麻酔法 (MLBP-TIVA) において調節呼吸が呼吸循環器系機能へ及ぼす影響 (2010)
  • Author(s): 石塚友人, 伊丹貴晴, 三好健二郎, 山下和人
  • Organizer: 第150回日本獣医学会
  • Place of Presentation: 帯広畜産大学
  • Year and Date: 2010-09-17
• [Presentation] メデトミジン-リドカイン-ブトルファノーループロポフォールを用いた馬の全静脈麻酔 1.2%プロポフォール製剤の応用 (2010)
  • Author(s): 齊藤元晃, 伊丹貴晴, 石塚友人, 三好健二郎, 山下和人
  • Organizer: 第80回獣医麻酔外科学会
  • Place of Presentation: 大宮ソニックシティ
  • Year and Date: 2010-08-01
• [Presentation] メデトミジン-リドカイン-ブトルファノーループロポフォールを用いた馬の全静脈麻酔 2.調節呼吸の影響 (2010)
  • Author(s): 長櫓司, 伊丹貴晴, 石塚友人, 三好健二郎, 山下和人
  • Organizer: 第80回獣医麻酔外科学会
  • Place of Presentation: 大宮ソニックシティ
  • Year and Date: 2010-08-01
• [Presentation] メデトミジン-リドカイン-ブトルファノーループロポフォールを用いた馬の全静脈麻酔 3.調節呼吸下での保定体位の影響 (2010)
  • Author(s): 須藤佳奈子, 伊丹貴晴, 石塚友人, 三好健二郎, 山下和人
  • Organizer: 第80回獣医麻酔外科学会
  • Place of Presentation: 大宮ソニックシティ
  • Year and Date: 2010-08-01
• [Presentation] メデトミジン-リドカイン-ブトルファノーループロポフォールを用いた馬の全静脈麻酔 4.馬の去勢術への臨床応用 (2010)
  • Author(s): 鑓田祐佳里, 伊丹貴晴, 石塚友人, 三好健二郎, 山下和人
  • Organizer: 第80回獣医麻酔外科学会
  • Place of Presentation: 大宮ソニックシティ
  • Year and Date: 2010-08-01
• [Presentation] Evaluation of cardiopulmonary effects of total intravenous anesthesia using a drug combination of medetomidine, lidocaine, butorphanol and propofol (MLBP-TIVA) with or without controlled ventilation and effect of positioning in mechanically ventilated horses.
  • Author(s): T Ishizuka, T Nagaro, K Sudo, T Itami, J Tamura, S Fukui, K Miyoshi, K Yamashita.
  • Organizer: 11th World Congress of Veterinary Anesthesia
  • Place of Presentation: ケープタウン国際コンベンションセンター
• [Presentation] Evaluation of cardiopulmonary effects of total intravenous anesthesia using a drug combination of medetomidine, lidocaine, butorphanol and propofol (MLBP-TIVA) with or without controlled ventilation and effect of positioning in mechanically ventilated horses.
  • Author(s): T Ishizuka, T Nagaro, K Sudo, T Itami, J Tamura, S Fukui, K Miyoshi, K Yamashita.
  • Organizer: 2nd Conference of Asian Society of Veterinary Surgery
  • Place of Presentation: 南京農業大学
• [Remarks] 酪農学園大学獣医学部伴侶動物医療教育群 教育獣医麻酔学ユニットホームページ
  • URL: http://www.rakuno.ac.jp/dep05/sec5/u1/unit.htm
• [Remarks] 酪農学園大学獣医学部伴侶動物医療教育群教育獣医麻酔学ユニットホームページ
  • URL: http://www.rakuno.ac.jp/dep05/sec5/u1/unit.htm
• [Remarks] 酪農学園大学獣医学部伴侶動物医療教育群教育獣医麻酔学ユニットホームページ
  • URL: http://www.rakuno.ac.jp/dep05/sec5/u1/unit.htm