| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Many organic compounds which possess a biaryl skeleton were found from the nature, and some exhibit interesting biological activities. However, there have been a few methods for the synthesis of highly functionalized biaryl molecules. Recently, a palladium-mediated intramolecular coupling reaction has been recognized as the useful technique for the construction of such compounds. In this study, we developed the synthetic methods for biaryl-type molecules, and performed the total synthesis of several natural products.
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