Total synthesis and structure-activity relationship study of citridone A, a new potentiator of antifungal miconazole activity
| Project/Area Number |
22590012
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 合成化学 / 創薬化学 / Citridone A / 全合成 / 深在性真菌症 / 抗真菌剤 / 構造活性相関研究 / 創薬研究 / citridone A / 誘導体合成 / 抗真菌薬 / 位置選択的ヨード環化反応 / 絶対構造の決定 |
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| Research Abstract |
We have achieved total synthesis of citridone A (1), a new potentiator of antifungal miconazole activity. Extension of this chemistry for the structure-activity relationship study successfully produced new citridone A analogs.
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Report
(4 results)
Research Products
(4 results)
