| Project/Area Number |
22590019
|
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
|
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| Research Institution | Kinjo Gakuin University (2011-2012)
Tokyo University of Pharmacy and Life Science (2010) |
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Principal Investigator |
AOYAGI Yutaka 金城学院大学, 薬学部, 教授 (70212389)
|
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
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| Keywords | 環境調和型化学 / 創薬 / 構造活性相関 / 生物活性 / 創薬シーズ / リパーゼTL / 光学分割 / 抗トリパノソーマ / 抗炎症 / ジテルペン / マイクロ波 / 環境調和型 / マイクロウェーブ / ent-カウレンアナログ / salvileucalin類 / トリプトライドアナログ / ent-カウレン / トリプドライドアナログ |
|---|
| Research Abstract |
The project entitled “synthesis and structure-activityrelationship of biologically active natural products and their analogues based on greenchemistry” was studied. Namely, the project includes 1) isolation of secondarymetabolites from cultivated plants by using HPLC with water-alcohol solvent systems whichare environmentally friendly, 2) synthesis of biologically active natural products viakinetic resolution by using Lipase TL, a cold active enzyme, as a key step, and 3) synthesisof medicinal seed compounds by using microwave irradiation
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