New deployment of the synthetic method utilized the characteristic of radical species
| Project/Area Number |
22590026
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Hyogo University of Health Sciences |
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Principal Investigator |
MIYABE HIDETO 兵庫医療大学, 薬学部, 教授 (10289035)
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| Co-Investigator(Kenkyū-buntansha) |
甲谷 繁 兵庫医療大学, 薬学部, 講師 (00242529)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 有機化学 / 合成化学 / ラジカル / 連続反応 / ルイス酸 / 酸化チタン / 薬学 / 閉環反応 / 不斉合成 / 光触媒 / 触媒・化学プロセス |
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| Research Abstract |
The cascade or sequential reactions based on radical chemistry were investigated. I found that the sequential reaction of the intermediates arynes, generated from benzynes and formamides, with dialkylzinc proceeded. Next, I found that the cascade radical reactions, starting from the polarity-mismatched perfluoroalkyl radical addition to an electron-deficient acceptor, proceeded effectively. These reactions proceeded with good enantioselectivities by employing chiral Lewis acid. Additinally, the synthetically useful photocatalytic reduction of ketones was developed by using titanium dioxide.
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Report
(4 results)
Research Products
(58 results)
