| Project/Area Number |
22590046
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SAITO Hiroyuki 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (60300919)
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| Co-Investigator(Renkei-kenkyūsha) |
TANAKA Masafumi 神戸薬科大学, 薬学部, 講師 (40411904)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 脂質異常症 / アミロイドーシス / リポタンパク質 / アポリポタンパク質 / フォールディング構造異常 / フォールディング構造 / アミロイド線維 / 脂質膜 / 脂質結合構造 / 部位特異的蛍光標識 |
|---|
| Research Abstract |
To probe the structural effects of naturally occurring mutations of apolipoproteins that lead to hypolipoproteinemia and systemic amyloidosis, we examined the tertiary structure, stability, lipid-binding property, and aggregation propensity of apolipoprotein A-I and E variants. The results indicate that the disruption of the N-terminal helix bundle and the C-terminal helical structure in apolipoproteins caused by the mutations leads to the critical outcomes of diseases.
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