| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
The purpose of this project was to evaluate the relationship peroxisomal dysfunction anddemyelination. In this study, we focused on the ER stress and innate immunity in ABCD1-deficient primary astrocytes. Dysfunction of ABCD1, a peroxisomal membrane protein, caused a neurodegenerative disease called adrenoleukodystropy. We found that treatment of ligands for pattern recognition receptors induced the expression of cytokines and antiviral proteins in ABCD1-deficient astrocytes. These results suggest that dysfunction of ABCD1 lead to the disturbance of innate immune response, which result in the demyelination in adrenoleukodystrophy.
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