Exploring the novel cycloocygenase-inhibition-independent effects of indomethacin
| Project/Area Number |
22590079
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MURAYAMA Toshihiko 千葉大学, 大学院・薬学研究院, 教授 (90174317)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 薬理学・細胞情報伝達学 / インドメタシン / アラキドン酸 / 脂肪細胞 / NSAID / COX阻害非依存作用 / FAT/CD36 / PPARγ / 上皮間葉転換(EMT) / MMP-9 / COX阻害非依存的作用 |
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| Research Abstract |
This project had started to elucidate the mechanisms of the inhibitory effects of indomethacin on arachidonic acid uptake. In this project, we have elucidated the detailed mechanisms of the uptake of arachidonic acid as well as the antagonistic effect on human EP2 receptors by indomethacin treatments in human colon cancer cells. Additionally, we have shown that indomethacin can induce epithelial-mesenchymal transition in human lung cancer cells. Moreover, we have indicated that indomethacin could reduce the newly synthesis of the triglyceride in mouse adipocyte. Since we have already started to investigate the effects of newly synthesized indole-compounds on cancer cells, we believe that the findings we have obtained through the project can be applied to the future project for finding novel drugs for cancer therapy.
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Report
(4 results)
Research Products
(22 results)
