Modulation of proliferation and differentiation capacitiesby solute carrier transporters in neural progenitor cells

• Project/Area Number: 22590081
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Kanazawa University
• Principal Investigator: NAKAMICHI Noritaka 金沢大学, 薬学系, 准教授 (10401895)
• Co-Investigator(Kenkyū-buntansha): KATO Yukio 金沢大学, 薬学系, 教授 (30251440)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 脳・神経 / 脳神経疾患 / 神経科学 / 薬理学 / 輸送担体

Research Abstract

To clarify the physiological role of solute carrier (SLC) transporters expressed in neural progenitor cells (NPCs), we examined effects of SLC transporters on proliferation and differentiation capacities in NPCs. As a result, it was suggested that carnitine/organic cation transporter OCTN1/SLC22A4 may be primary organic cation transporter in NPCs, and may suppress proliferation and promote neuronal differentiation of NPCs via uptake of the antioxidant ergothioneine.

Research Products

• [Journal Article] Role of organic cation/carnitine transporter 1 in uptake of phenformin and inhibitory effect on complex I respiration in mitochondria (2013)
  • Author(s): hitara, Y., Nakamichi, N., Norioka, M., Shima, h., Kato, Y., Horie, T
  • Journal Title: in uptake of phenformin and in mitochondria Volume: 132 Issue: 1 Pages: 32-42
  • DOI: 10.1093/toxsci/kfs330
  • Peer Reviewed
• [Journal Article] TP binding cassette transporters in two distinct compartments of skin contribute to transdermal absorption of a typical substrate (2013)
  • Author(s): Hashimoto, N., Nakamichi, N., Uwafuji, S., Yoshida, K., Sugiura, T., Tsuji, A., Kato, Y.
  • Journal Title: J. Control. Release Volume: 165 Issue: 1 Pages: 54-61
  • DOI: 10.1016/j.jconrel.2012.10.011
  • Peer Reviewed
• [Journal Article] Pharmacokinetic modeling of hepatocyte growth factor in experimental animals and humans (2013)
  • Author(s): Tomoko Sugiura et al.
  • Journal Title: J. Pharm. Sci. Volume: 102(1) Issue: 1 Pages: 237-249
  • DOI: 10.1002/jps.23337
  • Peer Reviewed
• [Journal Article] Functional expression of carnitine/organic cation transporter OCTN1 in mouse brain neurons: Possible involvement in neuronal differentiation (2012)
  • Author(s): Nakamichi, N., Taguchi, T., Hosotani, H., Wakayama, T., Shimizu, T., Sugiura, T., Iseki, S., Kato, Y
  • Journal Title: Neurochem. Int Volume: 61 Issue: 7 Pages: 1121-1132
  • DOI: 10.1016/j.neuint.2012.08.004
  • NAID: 120004966621
  • Peer Reviewed
• [Journal Article] Promotion of both proliferation and differentiation in pluripotent P19 cells with stable overexpression of the glutamine transporter Slc38a1 (2012)
  • Author(s): Masato Ogura et al.
  • Journal Title: PLoS ONE Volume: 7(10) Issue: 10 Pages: e48270-e48270
  • DOI: 10.1371/journal.pone.0048270
  • Peer Reviewed
• [Journal Article] Promoted neuronal differentiation after activation of alpha4/beta2 nicotinic acetylcholine receptors in undifferentiated neural progenitors (2012)
  • Author(s): Takeshi Takarada, Noritaka Nakamichi, Seiya Kitajima, Ryo Fukumori, Ryota Nakazato, Nguyen Quynh Le, Yeong-Hun Kim, Koichi Fujikawa, Miki Kou and Yukio Yoneda
  • Journal Title: PLoS ONE Volume: 7 Issue: 10 Pages: e46177-e46177
  • DOI: 10.1371/journal.pone.0046177
  • Peer Reviewed
• [Journal Article] Possible neuroprotective property of nicotinic acetylcholine receptors in association with predominant upregulation of glial cell line-derived neurotrophic factor in astrocytes. (2012)
  • Author(s): Takeshi Takarada, Noritaka Nakamichi, Hirofumi Kawagoe, Masato Ogura, Ryo Fukumori, Ryota Nakazato, Koichi Fujikawa, Miki Kou and Yukio Yoneda
  • Journal Title: J. Neurosci. Res Volume: 90(11) Issue: 11 Pages: 2074-2085
  • DOI: 10.1002/jnr.23101
  • Peer Reviewed
• [Journal Article] Delayed Mitochondrial Membrane Potential Disruption by ATP in Cultured Rat Hippocampal Neurons Exposed to <I>N</I>-Methyl-D-Aspartate (2012)
  • Author(s): Fujikawa K, Nakamichi N, Kato S, Fukumori R, Hida M, Takarada T & YonedaY
  • Journal Title: Journal of Pharmacological Sciences Volume: 119 Issue: 1 Pages: 20-29
  • DOI: 10.1254/jphs.12034FP
  • NAID: 10030760182
  • ISSN: 1347-8613, 1347-8648
  • Peer Reviewed
• [Journal Article] Transferrin receptor-1 suppresses neurite outgrowth in neuroblastoma Neuro2A cells (2011)
  • Author(s): Yukary Nakamura, Noritaka Nakamichi, Takeshi Takarada, Kiyokazu Ogita, Yukio Yoneda
  • Journal Title: Neurochem.Int. Volume: 60 Issue: 5 Pages: 448-457
  • DOI: 10.1016/j.neuint.2011.08.018
  • Peer Reviewed
• [Journal Article] DZK1 regulates breast cancer resistance protein in small intestine (2011)
  • Author(s): Shimizu, T., Sugiura, T., Wakayama, T.,Kijima, A., Nakamichi, N., Iseki, S.,Silver, D.L., Kato, Y
  • Journal Title: Drug Metab. Dispos Volume: 39 Issue: 11 Pages: 2148-2154
  • DOI: 10.1124/dmd.111.040295
  • Peer Reviewed
• [Journal Article] Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent (2011)
  • Author(s): Takeuchi, K., Sugiura, T., Umeda, S.,Matsubara, K., Horikawa, M., Nakamichi, N., Silver, D.L., Ishiwata, N., Kato, Y
  • Journal Title: Drug Metab. Dispos Volume: 39 Issue: 6 Pages: 1088-1096
  • DOI: 10.1124/dmd.110.037960
  • Peer Reviewed
• [Journal Article] A pivotal role of mitochondrial free calcium in neurotoxicity mediated by N-methyl-D-aspartate receptors in cultured rat hippocampal neurons (2011)
  • Author(s): Yuki Kambe
  • Journal Title: Neurochem Int Volume: 59 Issue: 1 Pages: 10-20
  • DOI: 10.1016/j.neuint.2011.03.018
  • Peer Reviewed
• [Journal Article] Exacerbated vulnerability to oxidative stress in astrocytic C6 glioma cells with stableoverexpression of the glutamine transporter slc38a1 (2011)
  • Author(s): Masato Ogura, et al.
  • Journal Title: Neurochemistry International Volume: 58(4) Pages: 504-511
  • Peer Reviewed
• [Journal Article] Gradual downregulation of protein expression of the partner GABABR2 subunit duringpostnatal brain development inmice defective of GABA_BR1 subunit (2011)
  • Author(s): Masaki Fukui, et al.
  • Journal Title: Journal of Pharmacological Sciences Volume: 115(1) Pages: 45-55
  • Peer Reviewed
• [Journal Article] Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in mouse small intestine and liver (2010)
  • Author(s): Sugiura, T., Kato, S., Shimizu, T.,Wakayama, T., Nakamichi, N., Kubo, Y.,Iwata, D., Suzuki, K., Soga, T., Asano, M., Iseki, S., Tamai, I., Tsuji, A., Kato, Y.
  • Journal Title: Drug Metab. Dispos Volume: 38 Issue: 10 Pages: 1665-1672
  • DOI: 10.1124/dmd.110.032763
  • Peer Reviewed
• [Journal Article] Preferential inhibition by anti-diarrheic 2-methoxy-4-methylphenol of Ca2+influx across acquired N-methyl-D-aspartate receptor channels composed of NR1/NR2B subunit assembly (2010)
  • Author(s): Nakamichi, N., Fukumori, R., Takarada, T., Kambe, Y., Yamamoto, T., Matsushima, N., Moriguchi, N., Yoneda, Y
  • Journal Title: J. Neurosci. Res Volume: 88 Issue: 11 Pages: 2483-2493
  • DOI: 10.1002/jnr.22399
  • Peer Reviewed
• [Journal Article] PDZK1 regulates organic anion transporting polypeptide Oatpla in mouse smallintestine (2010)
  • Author(s): Tomoko Sugiura, et al.
  • Journal Title: Drug Metabolism and Pharmacokinetics Volume: 25(6) Pages: 588-598
  • Peer Reviewed
• [Journal Article] Requirement of both NR3A and NR3B subunits for dominant negative properties on Ca^<2+> mobilization mediated by acquired N-methyl-D-aspartate receptor channels intomitochondria (2010)
  • Author(s): Ryo Fukumori, et al.
  • Journal Title: Neurochemistry International Volume: 57(7) Pages: 730-737
  • Peer Reviewed
• [Journal Article] Functional Expression of Carnitine/Organic Cation Transporter OCTN I/SLC22A4 inmouse small intestine and liver (2010)
  • Author(s): Tomoko Sugiura, et al.
  • Journal Title: Drug Metabolism and Disposition Volume: 38(10) Pages: 1665-1672
  • Peer Reviewed
• [Journal Article] Preferential inhibition by antidiarrheic 2-methoxy-4-methylphenol of Ca^<2+>influx across acquired N-methyl-D-aspartate receptor.channels composed of NR1/NR2B subunitassembly (2010)
  • Author(s): Noritaka Nakamichi, et al.
  • Journal Title: Journal of Neuroscience Research Volume: 88(11) Pages: 2483-2493
  • Peer Reviewed
• [Presentation] odulation of proliferation and differentiation activity by solute carrier OCTN1/SLC22A4 in neural progenitor cells (2013)
  • Author(s): Nakamichi, N., Ishimoto, T., Hosotani,H., Sugiura, T., Kato, Y
  • Organizer: 24th Biennial Meeting ISN-ASN
  • Place of Presentation: Cancun Convention Center(Mexico)
  • Year and Date: 2013-04-24
• [Presentation] 中枢神経系疾患の薬物治療における膜輸送体OCTN1/SLC22A4の役割 (2013)
  • Author(s): 中道 範隆, 杉浦 智子, 加藤 将夫
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2013-03-30
• [Presentation] 神経幹細胞における膜輸送体OCTN1の機能的発現と細胞増殖に及ぼす役割. (2013)
  • Author(s): 中道 範隆, 石本 尚大, 細谷 拓史, 杉浦智子, 加藤 将夫
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2013-03-23
• [Presentation] 中枢神経系疾患の薬物治療における膜輸送体OCTN1/SLC22A4の役割 (2013)
  • Author(s): 中道 範隆 et al.
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: パシフィコ横浜（神奈川県）
• [Presentation] 異物排出トランスポーターMrp阻害剤による神経芽腫細胞株の選択的増殖抑制 (2013)
  • Author(s): 中道 範隆 et al.
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: パシフィコ横浜（神奈川県）
• [Presentation] 神経幹細胞における膜輸送体OCTN1の機能的発現と細胞増殖に及ぼす役割 (2013)
  • Author(s): 中道 範隆 et al.
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡国際会議場（福岡県）
• [Presentation] Regulation of maturation by solute carrier OCTN1/SLC22A4 in mouse cortical neurons (2012)
  • Author(s): Nakamichi, N., Hosotani, H., Taguchi,T., Sugiura, T., Kato, Y
  • Organizer: 11th Biennial Meeting of APSN and 55th Meeting of JSN
  • Place of Presentation: Kobe International Conference Center(Hyogo)
  • Year and Date: 2012-10-02
• [Presentation] Suppression of proliferation by carnitine/organic cation transporter OCTN1 (SLC22A4) in neural progenitor cells (2012)
  • Author(s): Ishimoto, T., Nakamichi, N., Hosotani,H., Sugiura, T., Kato, Y
  • Organizer: 11th Biennial Meeting of APSN and 55th Meeting of JSN, Kobe International
  • Place of Presentation: Conference Center (Hyogo)
  • Year and Date: 2012-10-02
• [Presentation] OCTN1/SLC22A4が神経細胞の増殖・分化に及ぼす影響 (2012)
  • Author(s): 中道 範隆, 若山 友彦, 杉浦 智子, 井関尚一, 加藤 将夫
  • Organizer: 第7回トランスポーター研究会年会
  • Place of Presentation: 京都大学農学部(京都府)
  • Year and Date: 2012-06-10
• [Presentation] 膜輸送体OCTN1によるマウス神経芽腫細胞株Neuro2aの分化抑制 (2012)
  • Author(s): 中道 範隆, 細谷 拓史, 田口 貴之, 杉浦智子, 加藤 将夫
  • Organizer: 第85回日本薬理学会年会,国立京都国際会館
  • Place of Presentation: 京都府
  • Year and Date: 2012-03-16
• [Presentation] 新規血小板増多剤Eltrombopagと臨床併用薬とのトランスポーターを介した薬物間相互作用 (2012)
  • Author(s): 杉浦 智子 et al.
  • Organizer: 第33回日本臨床薬理学会学術総会
  • Place of Presentation: 沖縄コンベンションセンター（沖縄県）
• [Presentation] Interaction of breast cancer resistance protein (BCRP/ABCG2) with PDZ adaptor PDZK1 and therapeutic agents in small intestine (2012)
  • Author(s): Takuya Shimizu et al.
  • Organizer: Globalization of Pharmaceutics Education Network Meeting 2012
  • Place of Presentation: Monash University (Melbourne)
• [Presentation] Association of OCTN1/SLC22A4 with activation of hepatic stellate cells (2012)
  • Author(s): Shiori Kawabata et al.
  • Organizer: 日本薬物動態学会第27回年会
  • Place of Presentation: タワーホール船堀（東京都）
• [Presentation] Involvement of solute carrier OCTN1/SLC22A4 in intracerebral distribution of drugs acting on the central nervous system (2012)
  • Author(s): Keigo Nakayama et al.
  • Organizer: 日本薬物動態学会第27回年会
  • Place of Presentation: タワーホール船堀（東京都）
• [Presentation] 異物排出ABCトランスポーターを標的とした外用添加剤による皮内動態制御 (2012)
  • Author(s): 及川 真志 et al.
  • Organizer: 第124回日本薬学会北陸支部会
  • Place of Presentation: 富山大学杉谷キャンパス（富山県）
• [Presentation] 膜輸送体OCTN1による未分化神経細胞モデルNeuro2aの分化制御 (2012)
  • Author(s): 木下 直紀 et al.
  • Organizer: 第124回日本薬学会北陸支部会
  • Place of Presentation: 富山大学杉谷キャンパス（富山県）
• [Presentation] カルニチン/有機カチオントランスポーターOCTN1 の肝臓での機能的発現と肝線維化に及ぼす影響 (2012)
  • Author(s): 杉浦 智子 et al.
  • Organizer: 第34回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 京都大学薬学部（京都府）
• [Presentation] Gastrointestinal absorption of metformin regulated by carnitine/organic cation transporter OCTN1 (SLC22A4) (2012)
  • Author(s): Satoshi Asano et al.
  • Organizer: 18th North American Regional ISSX Meeting
  • Place of Presentation: Hilton Anatole Dallas Hotel (Dallas)
• [Presentation] OCTN1/SLC22A4 is functionally expressed in hepatic non-parenchymal cells (2012)
  • Author(s): Ryuichi Harada et al.
  • Organizer: 18th North American Regional ISSX Meeting
  • Place of Presentation: Hilton Anatole Dallas Hotel (Dallas)
• [Presentation] Regulation of maturation by solute carrier OCTN1/SLC22A4 in mouse cortical neurons (2012)
  • Author(s): Noritaka Nakamichi et al.
  • Organizer: 11th Biennial Meeting of APSN and 55th Meeting of JSN
  • Place of Presentation: Kobe International Conference Center (Kobe)
• [Presentation] Suppression of proliferation by carnitine/organic cation transporter OCTN1 (SLC22A4) in neural progenitor cells (2012)
  • Author(s): Takahiro Ishimoto et al.
  • Organizer: 11th Biennial Meeting of APSN and 55th Meeting of JSN
  • Place of Presentation: Kobe International Conference Center (Kobe)
• [Presentation] ATP-induced delay of mitochondrial membrane potential disruption by NMDA in cultured rat hippocampal neurons (2012)
  • Author(s): Koichi Fujikawa et al.
  • Organizer: 11th Biennial Meeting of APSN and 55th Meeting of JSN
  • Place of Presentation: Kobe International Conference Center (Kobe)
• [Presentation] PDZ adaptor PDZK1 is a functional regulator of breast cancer resistance protein (BCRP/ABCG2) in small intestine (2012)
  • Author(s): Takuya Shimizu et al.
  • Organizer: International Symposium on Epithelial Barrier and Transport 2012
  • Place of Presentation: Ritsumeikan University (Kusatsu)
• [Presentation] OCTN1/SLC22A4が神経細胞の増殖・分化に及ぼす影響 (2012)
  • Author(s): 中道 範隆 et al.
  • Organizer: 第7回トランスポーター研究会年会
  • Place of Presentation: 京都大学農学部（京都府）
• [Presentation] 皮膚組織に発現するP-gpおよびBCRPを標的とした基質の皮内動態制御 (2012)
  • Author(s): 橋本 直人 et al.
  • Organizer: 日本薬剤学会第27年会
  • Place of Presentation: 神戸国際会議場（兵庫県）
• [Presentation] 血小板増加薬Eltrombopagと併用薬との薬物間相互作用機構 (2012)
  • Author(s): 竹内和也, et al
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 北海道大学(北海道)
• [Presentation] 膜輸送体OCTN1によるマウス神経芽腫細胞株Neuro2aの分化抑制 (2012)
  • Author(s): 中道範隆, et al
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 国立京都国際会館(京都府)
• [Presentation] Involvement of OCTN1/SLC22A4 in uptake of ergothioneine and neurite outgrowth in murine neurons (2011)
  • Author(s): Hosotani, H., Nakamichi, N., Taguchi,T., Wakayama, T., Sugiura, T., Iseki, S.,Kato, Y
  • Organizer: 日本薬物動態学会第26回年会
  • Place of Presentation: 広島国際会議場(広島県)
  • Year and Date: 2011-11-18
• [Presentation] ニコチンによる神経幹細胞の機能制御 (2011)
  • Author(s): 北島聖也, et al
  • Organizer: 第120回日本薬理学会近畿部会
  • Place of Presentation: ホテルグランビア京都(京都府)
  • Year and Date: 2011-11-11
• [Presentation] マウス神経細胞におけるカルニチン/有機カチオントランスポーターOCTN1の機能的発現 (2011)
  • Author(s): 中道 範隆, 田口 貴之, 細谷 拓史, 杉浦智子, 加藤 将夫
  • Organizer: 第54回日本神経化学会大会
  • Place of Presentation: 山代温泉 瑠璃光(石川県)
  • Year and Date: 2011-09-28
• [Presentation] Inhibitory effect of uremic toxins on hepatic uptake of SN-38 (2011)
  • Author(s): Saki Umeda, et al
  • Organizer: 日本薬物動態学会第26回年会
  • Place of Presentation: 広島国際会議場(広島県)
• [Presentation] Involvement of OCTN1/Octn1 in phenformin-induced mitochondrial toxicity (2011)
  • Author(s): Natsuko Kikuta, et al
  • Organizer: 日本薬物動態学会第26回年会
  • Place of Presentation: 広島国際会議場(広島県)
• [Presentation] Physiologically-based pharmacokinetic model for hepatocyte growth factor (2011)
  • Author(s): Kazusa Sano, et al
  • Organizer: 日本薬物動態学会第26回年会
  • Place of Presentation: 広島国際会議場(広島県)
• [Presentation] PDZ adaptor PDZK1 regulates expression of breast cancer resistance protein (BCRP) on apical membrane in small intestine (2011)
  • Author(s): Takuya Shimizu, et al
  • Organizer: 日本薬物動態学会第26回年会
  • Place of Presentation: 広島国際会議場(広島県)
• [Presentation] Involvement of carnitine/organic cation transporter OCTN1 in gastrointestinal absorption of metformin (2011)
  • Author(s): Noritaka Nakamichi, et al
  • Organizer: 日本薬物動態学会第26回年会
  • Place of Presentation: 広島国際会議場(広島県)
• [Presentation] Functional and localization of P-glycoprotein and brest cancer resistance protein expressed in mouse skin (2011)
  • Author(s): Naoto Hashimoto, et al
  • Organizer: 日本薬物動態学会第26回年会
  • Place of Presentation: 広島国際会議場(広島県)
• [Presentation] Involvement of OCTN1 in dimethylnitrosamine (DMN)-induced liver fibrosis (2011)
  • Author(s): Ryuichi Harada, et al
  • Organizer: 日本薬物動態学会第26回年会
  • Place of Presentation: 広島国際会議場(広島県)
• [Presentation] Evaluation of possible drug-drug interaction between eitrotnbopag and coadministe red drugs via hepatic transporters (2011)
  • Author(s): Kazuki Matsubara, et al
  • Organizer: 日本薬物動態学会第26回年会
  • Place of Presentation: 広島国際会議場(広島県)
• [Presentation] マウス神経細胞におけるカルニチン/有機カチオントランスポーターOCTN1の機能的発現 (2011)
  • Author(s): 中道範隆, et al
  • Organizer: 第54回日本神経化学会大会
  • Place of Presentation: 山代温泉瑠璃光(石川県)
• [Presentation] カルニチン/有機カチオントランスポーターOCTN1による神経突起伸展制御 (2011)
  • Author(s): 細谷拓史, et al
  • Organizer: 第54回日本神経化学会大会
  • Place of Presentation: 山代温泉瑠璃光(石川県)
• [Presentation] Phenforminにより引き起こされるミトコンドリア障害に対するOCTN1/Octn1の関与 (2011)
  • Author(s): 設楽悦久, et al
  • Organizer: 第6回トランスポーター研究会年会
  • Place of Presentation: 東北大学(宮城県)
• [Presentation] PDZK1による消化管排出トランスポーターBCRPの制御と薬物動態への影響 (2011)
  • Author(s): 杉浦智子, et al
  • Organizer: 第6回トランスポーター研究会年会
  • Place of Presentation: 東北大学(宮城県)
• [Presentation] octn1/slc22a4遺伝子欠損マウスを用いたDMN誘発性肝線維化の解析 (2011)
  • Author(s): 原田龍一, et al
  • Organizer: 第6回トランスポーター研究会年会
  • Place of Presentation: 東北大学(宮城県)
• [Presentation] PDZ adaptor PDZK1 regulates breast cancer resistance protein (ABCG2) in small intestine (2011)
  • Author(s): Takuya Shimizu, et al
  • Organizer: 日本分子生物学会第11回春季シンポジウム
  • Place of Presentation: 石川県立音楽堂(石川県)
• [Presentation] トランスポーターoctn1遺伝子欠損マウスを用いたDMN誘発性肝線維化の解析 (2011)
  • Author(s): 杉浦智子, et al
  • Organizer: 日本薬剤学会第26年会
  • Place of Presentation: タワーホール船堀(東京都)
• [Presentation] マウス皮膚に発現するP-gp/BCRPの機能と炎症時における役割 (2011)
  • Author(s): 橋本直人, et al
  • Organizer: 日本薬剤学会第26年会
  • Place of Presentation: タワーホール船堀(東京都)
• [Presentation] II型糖尿病治療薬metforminの体内動態に及ぼすカルニチン/有機カチオントヲンスポーターOCTN1の関与 (2011)
  • Author(s): 島広世, et al.
  • Organizer: 貨本薬学会第131年会
  • Place of Presentation: 誌上開催
• [Presentation] Phenforminによる毒性に対するミトコンドリア輸送担体の関与の解明 (2011)
  • Author(s): 則岡美咲, et al.
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 誌上開催
• [Presentation] マウス脳に発現するカルニチン/有機カチオントランスポーターOCTN1の機能解析 (2011)
  • Author(s): 中道範隆, et al.
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: 誌上開催
• [Presentation] マウス脳におけるカルニチン/有機カチオントランスポーターOCTN1(SLC22A4)の役割 (2010)
  • Author(s): 中道 範隆, 田口 貴之, 山田 寛哉, 杉浦智子, 加藤 将夫
  • Organizer: 第32回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 富山国際会議場(富山県)
  • Year and Date: 2010-11-30
• [Presentation] マウス脳に発現するカルニチン/有機カチオントランスポーターOCTN1の生理的機能解明 (2010)
  • Author(s): 田口貴之, et al.
  • Organizer: 第122回日本薬学会北陸支部会
  • Place of Presentation: 北陸大学薬学部(石川県)
  • Year and Date: 2010-11-21
• [Presentation] Mitochondrial uptake of organic cations as one of determinants of phenformiminduced lactic acidosis (2010)
  • Author(s): Misaki Norioka, et at.
  • Organizer: 第4回次世代を担う若手医療薬科学シンポジウム
  • Place of Presentation: 東京大学本郷キャンパス(東京都)
• [Presentation] Functional expression of carnitine/organic cation transporter OCTN1 (SLC22A4) in mouse brain (2010)
  • Author(s): Takayuki Taguchi, et al.
  • Organizer: 日本薬物動態学会第25回年会
  • Place of Presentation: 大宮ソニックシティ(埼玉県)
• [Presentation] Characterization of hepatic uptake mechanism for eitrombopag, a novel platelet increasing agent (2010)
  • Author(s): Kazuya Takeuchi, et al.
  • Organizer: 日本薬物動態学会第25回年会
  • Place of Presentation: 大宮ソニックシティ(埼玉県)
• [Presentation] グリア細胞におけるグルタミントランスポーターの細胞内局在 (2010)
  • Author(s): 佐古彩, et al.
  • Organizer: 第40回日本神経精神薬理学会年会
  • Place of Presentation: 仙台国際センター(宮城県)
• [Presentation] 静磁場曝露神経系前駆細胞における神経細胞分化能促進 (2010)
  • Author(s): 中里亮太, et al.
  • Organizer: Neuro2010
  • Place of Presentation: 神戸コンベンションセンター(兵庫県)
• [Presentation] PDZアダプターPDZK1による消化管トランスポーターOATPIAの剃御 (2010)
  • Author(s): 木嶋愛, et al.
  • Organizer: 第5回トランスポーター研究会年会
  • Place of Presentation: 東京医科大学病院(東京都)
• [Presentation] アダプタータンパク質による消化管トランスポーターの機能・発境舗御と薬物動態への影響 (2010)
  • Author(s): 杉浦智子, et al.
  • Organizer: 第5回トランスポーター研究会年会
  • Place of Presentation: 東京医科大学病院(東京都)
• [Remarks]
  • URL: http://www.p.kanazawa-u.ac.jp/~bunyaku/
• [Remarks] 分子薬物治療学研究室
  • URL: http://www.p.kanazawa-u.ac.jp/~bunyaku/
• [Remarks]
  • URL: http://www.p.kanazawa-u.ac.jp/~bunyaku/
• [Remarks]
  • URL: http://www.p.kanazawa-u.ac.jp/~bunyaku/