Epilepsy research focusing on the potassium buffering function of brain astrocytes
| Project/Area Number |
22590092
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Osaka University of Pharmaceutical Sciences |
|---|
Principal Investigator |
OHNO Yukihiro 大阪薬科大学, 薬学部, 教授 (00432534)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 薬理学 / てんかん / アストロサイト / 内向き整流性カリウムチャネル / カリウム緩衝機構 / 強直-間代発作 / 欠神発作 / 抗てんかん薬 / 疾患モデル / 扁桃体 |
|---|
| Research Abstract |
We focused on the potassium buffering function of brain astrocytes andanalyzed the pathophysiological changes in expression of the inwardly-rectifying potassium channel 4.1(Kir4.1), which mediates spatial potassium buffering in astrocytes, using various animal models ofepilepsy. Our results revealed that reduced expression (down-regulation) of astrocytic Kir4.1 channels inthe limbic system (e.g., amygdala and piriform cortex) is closely linked to induction of generalizedtonic-clonic seizures. In addition, studies using kindling models suggest that Kir4.1 channels negativelyregulate the epileptogenesis (i.e., induction and development of epileptic seizures). Thus, the presentstudy illustrates that astrocytic Kir4.1 channels would serve as a novel therapeutic target for epilepsy.
|
Report
(4 results)
Research Products
(79 results)
-
-
[Journal Article] Expressional analysis of inwardly rectifying Kir4.1 channels in Noda epileptic rat (NER)2013
Author(s)
Yuya Harada, Yuki Nagao, Saki Shimizu, Tadao Serikawa, Ryo Terada, Megumi Fujimoto, Aoi Okuda, Takahiro Mukai, Masashi Sasa, Yoshihisa Kurachi, Yukihiro Ohno
-
Journal Title
Brain Research
Volume: 1517
Pages: 141-149
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Pathophysiological alterations ofsynaptic vesicle protein 2A (SV2A) in Groggy rat,a rat model of absence seizure2012
Author(s)
Takahiro Okumura 、 Shizuka Ishihara, RyoTerada, Chie Tomita, Ryosuke Kitaya, KentaroTokutome, Tomoya Tanaka, Saki Shimizu,Yoshiko Kawai, Tadao Serikawa, Masashi Sasa,Yukihiro Ohno
Organizer
第85回日本薬理学会年会
Place of Presentation
京都
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
