Anti-carcinogenic effects of zinc by induction of apoptosis and inhibition of DNA methylation
| Project/Area Number |
22590126
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Hiroshima International University |
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Principal Investigator |
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| Project Period (FY) |
2010-10-20 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 亜鉛 / 抗がん / エピジェネティクス / ＤＮＡメチル化 / カドミウム / アポトーシス / ＭＭＰ / がん悪性化 / 発がん無機物質 / 重金属 / MMP / メタロチオネイン / マイクロアレー / DNAメチル化 / 細胞浸潤能 / 亜鉛イオノフォア |
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| Research Abstract |
Zinc (Zn) is an essential metal in humans and rodents. Zn in certain instances can also be anti-carcinogenic. In this study, we clarified that Zn is an inducer of apoptosis, programed tumor cell death. The concentration of Zn in cells determines mode of Zn-induced cell death. In addition, the involvement of metallothionein (MT), is induced by Zn, in the regulation of MMP2, has been implicated in tumor cell invasion, and cell invasion was examined. The result strongly suggests that MT promotes cell invasion by up-regulating MMP2. These results proposed that Zn can have both carcinogenic and anti-carcinogenic effects.
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Report
(5 results)
Research Products
(14 results)
