Chemopreventive effects of vitamin K cycle using human iPS cells
| Project/Area Number |
22590133
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Nagoya City University (2012)
Shinshu University (2010-2011) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUNAGA Tamihide 名古屋市立大学, 大学院・薬学研究科, 教授 (40209581)
OHMORI Shigeru 信州大学, 医学部附属病院, 教授 (70169069)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ケモプリベンション / ビタミン K / iPS 細胞 / PIVKA-II / VKORC1 / ビタミンKサイクル / ヒトiPS細胞 / 発がん予防機構 |
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| Research Abstract |
Final goal of this study was to find the way to improve the cancer chemotherapies and cancer chemo-preventions from the information of Vitamin K cycle-related genetic polymorphisms. The human iPS cells would be useful as an appropriate assay of a variety of drug metabolism study as well as the study of cancer chemo-preventions. The effect of Vitamin Kcycle-related genetic polymorphisms on warfarin maintenance dose was observed and this could havesome importance when warfarin prescribed during cancer chemotherapies.
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] CYP4F2 gene polymorphism as a contributor to warfarin maintenance dose in Japanese subjects.2012
Author(s)
Nakamura K, Obayashi K, Araki T, Aomori T, Fujita Y, Okada Y, Kurabayashi M, Hasegawa A, Ohmori S, Nakamura T, Yamamoto K.
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Journal Title
J Clin Pharm Ther
Volume: 37(4)
Pages: 481-485
Related Report
Peer Reviewed
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[Journal Article] Clinical screening assay for EGFR exon 19 mutations using PNA-clamp smart amplification process version 2 in lung adenocarcinoma.2011
Author(s)
Araki T, Shimizu K, Nakamura T, Baba M, Kawai Y, Nakamura K, Mitani Y, Obayashi K, Aomori T, Fujita Y, Miyamae Y, Kakegawa S, Kaira K, Lezhava A, Hayashizaki Y, Takeyoshi I, Yamamoto K.
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Journal Title
Oncol Rep
Volume: 26(5)
Pages: 1213-1219
Related Report
Peer Reviewed
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[Journal Article] Clinical screening assay for EGFR exon 19 mutations using PNA-clamp smart amplification process version 2 in lung adenocarcinoma2011
Author(s)
Takuya Araki, Kimihiro Shimizu, Tomonori Nakamura, Masaru Baba, Yuki Kawai, Katsunori Nakamura, Yasumasa Mitani, Kyoko Obayashi, Tohru Aomori, Yukiyoshi Fujita, Yohei Miyamae, Seiichi Kakegawa, Kyoichi Kaira, Alexander Lezhava, Yoshihide Hayashizaki, Izumi Takeyoshi, Koujirou Yamamoto
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Journal Title
Oncol Rep
Volume: 26
Pages: 1213-1219
DOI
Related Report
Peer Reviewed
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[Journal Article] Usefulness of peptide nucleic acid (PNA)-clamp smart amplification process version 2 (SmartAmp2) for clinical diagnosis of KRAS codon 1 2 mutations in lung adenocarcinoma: comparison of PNA-clamp Smart Amp2 and PCR-related methods.2010
Author(s)
Araki T, Shimizu K, Nakamura K, Nakamura T, Mitani Y, O bayashi K, Fujita Y, Kakegawa S, Miyamae Y, Kaira K, Ishid ao T, Lezhava A, Hayashizaki Y, Takeyoshi I, Yamamoto K
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Journal Title
J. Mol. Diagn.
Volume: 12(1)
Pages: 118-124
Related Report
Peer Reviewed
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[Journal Article] Pharmacokinetic individualization of high-dose methotrexate chemothe rapy for the treatment of localized osteosarcoma.2010
Author(s)
Fujita Y, Nakamura T, Aomori T, Nishiba H, Shinozaki T, Ya nagawa T, Takagishi K, Watan abe H, Okada Y, Nakamura K, Horiuchi R. Yamamoto K
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Journal Title
J. Chemother.
Volume: 22(3)
Pages: 186-190
Related Report
Peer Reviewed
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[Presentation] Small Molecule Compounds Enhance Differentiation to Hepatocytes from induced Pluripotent Stem Cells.2012
Author(s)
Yuki Kondo, Takahiro Iwao, Sachimi Yoshihashi, Kayo Mimori, Ruri Sugiyama, Takamitsu Sasaki, Kiyoshi Nagata, Kouichi Kurose, Takuro Niwa, Satoshi Yamaori, Shigeru Ohmori, Katsunori Nakamura, Tamihide Matsunaga
Organizer
第27回日本薬物動態学会年会
Place of Presentation
船堀
Related Report
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