How do the immune disorders affect drug metabolism ?
| Project/Area Number |
22590159
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Hyogo University of Health Sciences |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NISHIKAWA Jun-ichi 武庫川女子大学, 薬学部, 教授 (90218131)
FUJINO Hideki 兵庫医療大学, 薬学部, 講師 (90510975)
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| Co-Investigator(Renkei-kenkyūsha) |
IWASAKI Tsuyoshi 兵庫医療大学, 薬学部, 教授 (10151721)
MORIYA Nozomu 兵庫医療大学, 薬学部, 助手 (30509138)
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 免疫系不活化 / 肝薬物代謝酵素 / 炎症性サイトカイン / miRNA / 免疫系シグナル伝達 / 核内受容体 / ショットガン法 / プロテオミクス / 免疫沈降 / 免疫系賦活化 / 細菌感染 / １型アレルギー / 薬物動態学 / 医療薬学 / I型アレルギー / 医療薬剤学 / 肝薬物代謝 |
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| Outline of Final Research Achievements |
We have been interested in the cytokine signal transduction cascade and its effect on drug metabolism. To extract the unknown protein, which may play as transcriptional regulators for metabolic enzymes as well as inflammatory cytokines, we have conducted immune precipitation following shotgun proteomics using LC-Mass. Finally, a chaperon-like protein Bag6/Bat3 was extracted and revealed to bind p65 subunit of NF-kappa B. Then, our interests moved on the miRNA, which may regulate Bag6/Bat3 expression. Using human rheumatoid arthritis as a model disorder, we established Excel VBA algorithm to look for the miRNAs that could regulate irritation-related mRNAs.
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Report
(6 results)
Research Products
(4 results)
