| Project/Area Number |
22590195
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Meijo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Kenji 名城大学, 薬学部, 助教 (80294122)
TAKEUCHI Noriko 名城大学, 薬学部, 助手 (80076728)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 発生学 / 形態形成学 / セマフォリン / ミクログリア / 脳内ホメオスターシス / プレキシン / 脳内炎症 / 精神疾患 / 細胞分化・組織形成 / 那須-ハコラ病 |
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| Research Abstract |
Plexin-A1 is a receptor of semaphorins originally found as repulsive axon guidance molecules. Plexin-A1 deficient mice over 14-week-old were revealed to have significant deficits in prepulse inhibition of auditory startle reflex which can be also observed in psychiatric disease such as schizophrenia. Plexin-A1 deficient mice also displayed significant increase in locomotion activity and grooming behavior and age-dependent microglial overactivation and demyelination. Thus, plexin-A1 deficient mice is an animal model useful to obtain a novel finding which helps us clarify the pathogenic mechanism of psychiatric diseases recently suggested to be related to abnormal microglia, but still concealing essentially unknown factors.
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