Elucidation of the role of orexin type 2 receptor in the obesity resistance

• Project/Area Number: 22590228
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Toho University
• Principal Investigator: FUNATO Hiromasa 東邦大学, 医学部, 准教授 (90363118)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 解剖学 / 神経科学 / 体重制御 / 肥満 / 神経ペプチド / 摂食 / 神経解剖 / 神経回路 / 視床下部 / マウス / 体重調節

Research Abstract

To elucidate how orexin regulates body weight, we performed pharmacological and morphological studies. We found out that a specific subregion of the doral raphe nucleus is crucial for the regulation. In addition, we revealed the molecular diversity in the epigenetic mechanism of the neural groups including orexinergic neurons.

Research Products

• [Journal Article] Monoaminergic and neuropeptidergic neurons have distinct expression profiles of histone deacetylases (2013)
  • Author(s): Kenkichi Takase, Satoko Oda, Masaru Kuroda, Hiromasa Funato
  • Journal Title: PLoS One Volume: 8 Issue: 3 Pages: e58473-e58473
  • DOI: 10.1371/journal.pone.0058473
  • Peer Reviewed
• [Journal Article] Monoaminergic and neuropeptidergic neurons have distinct expression profiles of histone deacetylases (2013)
  • Author(s): Kenkichi Takase, Satoko Oda, Masaru Kuroda, *Hiromasa Funato
  • Journal Title: PLoS One Volume: 8
  • Peer Reviewed
• [Journal Article] Fasting and high-fat diet alter histone deacetylase expression in the medial hypothalamus (2011)
  • Author(s): Hiromasa Funato, Satoko Oda, Junko Yokofujita, Hiroaki Igarashi, Masaru Kuroda
  • Journal Title: PLoS One Volume: 6 Issue: 4 Pages: 1-8
  • DOI: 10.1371/journal.pone.0018950
  • Peer Reviewed
• [Journal Article] Altered gene expression of histone deacetylases in mood disorder patients (2010)
  • Author(s): Teruyuki Hobara, Shusaku Uchida, Koji Otsuki, Toshio Matsubara, Hiromasa Funato, Koji Matsuo, Masatomo Suetsugi, Yoshifumi Watanabe
  • Journal Title: Journal of Psychiatric Research Volume: 44 Issue: 8 Pages: 263-270
  • DOI: 10.1016/j.jpsychires.2011.01.016
  • Peer Reviewed
• [Journal Article] Dopamine D5 receptor immunoreactivity is differentially distributed in GABAergic interneurons and pyramidal cells in the rat medial prefrontal cortex (2010)
  • Author(s): Satoko Oda, Hiromasa Funato, Satomi Adachi-Akahane, Masanori Ito, Akiko Okada, Hiroaki Igarashi, Junko Yokofujita,Masaru Kuroda
  • Journal Title: Brain Research Volume: 1329 Pages: 89-102
  • DOI: 10.1016/j.brainres.2010.03.011
  • Peer Reviewed
• [Journal Article] Aberrant REST-mediated transcriptional regulation in major depressive disorder (2010)
  • Author(s): Koji Otsuki, Shusaku Uchida, Yusuke Wakabayashi, Toshio Matsubara, Teruyuki Hobara, Hiromasa Funato, Yoshifumi Watanabe
  • Journal Title: Journal of Psychiatric Research Volume: 44 Issue: 6 Pages: 378-384
  • DOI: 10.1016/j.jpsychires.2009.09.009
  • Peer Reviewed
• [Journal Article] Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in interpeduncular nucleus results in altered regulation of rapid eye movement sleep (2010)
  • Author(s): Hiromasa Funato, Makito Sato, Christopher M. Sinton, Laurent Gautron, S. Clay Williams, Amber Skach, Joel K. Elmquist, Arthur I. Skoultchi, Masashi Yanagisawa
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 107 Issue: 42 Pages: 18155-18160
  • DOI: 10.1073/pnas.1012764107
  • NAID: 120007137891
  • Peer Reviewed
• [Journal Article] Early life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodents (2010)
  • Author(s): Shusaku Uchida, Kumiko Hara, Ayumi Kobayashi, Hiromasa Funato, Teruyuki Hobara, Koji Otsuki, Hirotaka Yamagata, Bruce S. McEwen, Yoshifumi Watanabe
  • Journal Title: Journal of Neuroscience Volume: 30 Issue: 45 Pages: 15007-15018
  • DOI: 10.1523/jneurosci.1436-10.2010
  • Peer Reviewed
• [Journal Article] Dopamine D5 receptor immunoreactivity is differentially distributed in GABAergic interneurons and pyramidal cells in the rat medial prefrontal cortex. (2010)
  • Author(s): Oda S
  • Journal Title: Brain Research Volume: 1329 Pages: 89-102
  • Peer Reviewed
• [Journal Article] Early life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodents. (2010)
  • Author(s): Uchida S
  • Journal Title: Journal of Neuroscience Volume: 30 Pages: 15007-15018
  • Peer Reviewed
• [Presentation] Differential expression of histone deacetylases in neuronal groups regulating feeding and body weight (2013)
  • Author(s): Hiromasa Funato, Kenkichi Takase, Masaru Kuroda, Satoko Oda
  • Organizer: Keystone symposia
  • Place of Presentation: Banff Canada
  • Year and Date: 2013-03-18
• [Presentation] Monoaminergic and neuropeptidergic neurons show distinct expression profiles of histone deacetylases (2012)
  • Author(s): Kenkichi Takase, Satoko Oda, Junko Yokofujita, Masaru Kuroda, Hiromasa Funato
  • Organizer: 第35回日本神経科学学会大会 Neuro2012
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-12
• [Presentation] 摂食関連ペプチド MCHの多様な役割と、各行動に与える効果量のメタ分析 (2012)
  • Author(s): 高瀬堅吉, 小田哲子, 横藤田純子, 黒田優, 船戸弘正
  • Organizer: 日本行動科学学会 2012 年次総会
  • Place of Presentation: 東京
  • Year and Date: 2012-09-11
• [Presentation] Fasting and high-fat diet alter histone deacetylase expression in the medial hypothalamus (2012)
  • Author(s): 船戸弘正 高瀬堅吉 小田哲子 横藤田純子 黒田優
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 甲府
  • Year and Date: 2012-03-28
• [Presentation] Fasting and high-fat diet alter histone deacetylase expression in the medial hypothalamus (2012)
  • Author(s): 船戸弘正, 高瀬堅吉, 小田哲子, 横藤田純子, 黒田優
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学(山梨県甲府市)
  • Year and Date: 2012-03-28
• [Presentation] Forward genetic analysis of sleep behavior in mice (2012)
  • Author(s): Makito Sato, Christopher Sinton, Toshiyuki Motoike, Vivek Kumar, Hiromasa Funato, Joseph Takahashi, Masashi Yanagisawa
  • Organizer: FIRST 国際シンポジウム「行動神経科学の最前線ー睡眠の謎に挑むー」
  • Place of Presentation: 東京
  • Year and Date: 2012-03-19
• [Presentation] オレキシンと摂食・エネルギー代謝調節 (2011)
  • Author(s): 船戸弘正
  • Organizer: 第116回日本解剖学会総会・全国学術集会
  • Place of Presentation: (誌上開催)
  • Year and Date: 2011-03-28
• [Presentation] オレキシンと摂食・エネルギー代謝調節、シンポジウム-29「脳による摂食・エネルギー代謝調節」オレキシンと摂食・エネルギー代謝調節 (2011)
  • Author(s): 船戸弘正
  • Organizer: 第116回日本解剖学会総会・全国学術集会Journal of Physiological Sciences 誌上開催
• [Presentation] Dopamine D5 receptor immunoreactivity is differentially distributed in GABAergic interneurons and pyramidal cells in the rat medial prefrontal cortex (2010)
  • Author(s): Satoko Oda, Hiromasa Funato, Hiroaki Igarashi, Junko Yokofujita, Masaru Kuroda
  • Organizer: 第33回日本神経科学学会大会 Neuro 2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-03
• [Presentation] Loss of Goosecoid-like and Dgcr14 in interpeduncular nucleus alters the expression of REM sleep (2010)
  • Author(s): Hiromasa Funato, Makito Sato, Christopher M. Sinton, Laurent Gautron, S. Clay Williams, Joel K. Elmquist, Masaru Kuroda, Arthur I. Skoultchi, Masashi Yanagisawa
  • Organizer: 第33回日本神経科学学会大会Neuro 2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-02
• [Presentation] 摂食関連ペプチドMCHの多様な役割と、各行動に与える効果量のメタ分析
  • Author(s): 高瀬堅吉, 小田哲子, 横藤田純子, 黒田優, 船戸弘正
  • Organizer: 日本行動科学学会2012年次総会,
  • Place of Presentation: 東邦大学（東京都）
• [Presentation] Monoaminergic and neuropeptidergic neurons show distinct expression profiles of histone deacetylases
  • Author(s): Kenkichi Takase, Satoko Oda, Junko Yokofujita, Masaru Kuroda, Hiromasa Funato
  • Organizer: 第35回日本神経科学学会大会Neuro2012
  • Place of Presentation: 名古屋国際会議場（愛知県）
• [Presentation] Differential expression of histone deacetylases in neuronal groups regulating feeding and body weight
  • Author(s): Hiromasa Funato, Kenkichi Takase, Masaru Kuroda, Satoko Oda
  • Organizer: Keystone symposia
  • Place of Presentation: Fairmont Banff Springs (Banff, Canada)