Neuropeptidergic regulation of sociosexual behavior in rodents
| Project/Area Number |
22590229
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Teikyo University of Science & Technology (2011-2013)
Nippon Medical School (2010) |
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Principal Investigator |
KONDO Yasuhiko 帝京科学大学, 生命環境学部, 准教授 (00192584)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 視床下部室傍核 / 視索前野 / 扁桃体内側核 / 母性行動 / 嗅覚選好性 / 性行動 / オキシトシン / げっ歯類 / V1a受容体 / V1b受容体 / ラット / マウス / 社会行動 / 痛覚 / 視床下部 / 自律神経系 / オキシトシン受容体 / 視床下部外側野 / オレキシン / 内側視索前野 / 分界条床核 / サポリン |
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| Research Abstract |
The social behavior in rodents is regulated by the hypothalamus through sensory signals from chemosensory organs. In the hypothalamus, a neuropeptide, oxytocin, has been shown to mediate the regulation of social behavior. In this study, we examine sociosexual behavior in mice deficient for oxytocin gene (OTKO mice). Alternative choice test for conspecific odors revealed that OTKO mice showed a lack of preference for opposite-sex odor. In addition, OTKO deteriorated accept of male mouse in sexually naïve females, while OTKO did not affect male sexual behavior. We also tested for olfactory preference in female rats for pup odors. The experiment demonstrated that lower responsiveness to pup in virgin females than that of multiparous females was due to lower responsiveness of oxytocin neurons. Administration of oxytocin modified olfactory preference for pup in virgin females.
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Report
(5 results)
Research Products
(63 results)
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[Presentation] Effects of antiandrogen on sexual behavior, organ weight and hormone levels of male rats.2013
Author(s)
Kamishima, M., Uemura, H., Horii, Y., Watanabe, G., Taya, K., Harigaya, T., Takigami, H., Suzuki, G., Kondo, Y. and Kawaguchi, M.
Organizer
The 17th Federation of Asian Veterinary Association (FAVA) Congress
Place of Presentation
San Francisco
Related Report
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[Presentation] Effects of estrogenic compounds exposure within 24h after birth on partner preference and sexual behaviors in female rats.2013
Author(s)
Komine, C., Kamishima, M., Odashima, Y., Yoshida, M., Kondo, Y. and Kawaguchi, M.
Organizer
Society for Neuroscience
Place of Presentation
San Diego
Related Report
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[Presentation] Permanent influence of neonatal exposure to ethynyl estradiol on expression of estrogen receptor α in female rat brain.2013
Author(s)
Shiga, T., Nakamura, T.J., Goto, Y., Mizoguchi, Y., Komine, C., Kamishima, M., Yoshida, M., Kondo, Y. and Kawaguchi, M.
Organizer
Society for Neuroscience
Place of Presentation
San Diego
Related Report
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[Presentation] Effects of neonatal single injection of ethinyl estradiol on feeding, Learning and sexual behaviors in adult female rats.2013
Author(s)
Kamishima, M., Kobayashi, Y., Senbon, T., Komine, C., Uemura, H., Yoshida, M., Kondo, Y. and Kawaguchi, M.
Organizer
The 17th Federation of Asian Veterinary Association (FAVA) Congress
Place of Presentation
Taipei, Taiwan
Related Report
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