| Project/Area Number |
22590230
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Nippon Medical School |
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Principal Investigator |
OZAWA Hitoshi 日本医科大学, 大学院・医学研究科, 教授 (60169290)
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| Co-Investigator(Kenkyū-buntansha) |
IIJIMA Norio 日本医科大学, 医学部, 准教授 (00285248)
SAWAI Nobuhiko 日本医科大学, 医学部, 助教 (70307916)
YO Shunei 日本医科大学, 医学部, 助教 (70303435)
託見 健 日本医科大学, 医学部, 助教 (40553269)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | キスペプチン(kisspeptin) / HPG 軸 / GnRH / 視床下部 / ストレス / エネルギー代謝 / レプチン / グルココルチコイド受容体 / Kisspeptin / TIDA neuron / 星状膠細胞 / ストレス応答 / 生殖機能調節 / CRH / glucocorticoid receptor / キスペプチン / 性ステロイド / 性差 / 摂食調節 / 遺伝子発現 / 生殖神経内分泌 / 思春期 / 性機能調節 / 摂食制御調節 / ストレス応答調節 |
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| Research Abstract |
We have hisitochemically and molecular biologically studied on the morphofunctional role of kisspeptin and kisspeptin neurons in the hypothalamus which integrate the information about the reproduction, energy balance and stress response in the brain and rely to the HPG axis, and revealed an important role of kisspeptin neurons in the onset of puberty.
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