| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
We found that the molecular chaperone HSP90 regulates the stability of REV1, a Y-family DNA polymerase, and accumulation of REV1 at DNA damage sites. 2) We showed that suppression of heat shock transcription factor (HSF1) induces cellular senescence mediated by activation of p53-p21 pathway.
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