Comprehensive analyses of epigenetic abnormalities inadult T-cell leukemia/lymphoma (ATLL)

• Project/Area Number: 22590312
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Okayama University
• Principal Investigator: OKA Takashi 岡山大学, 大学院・医歯薬学総合研究科, 助教 (50160651)
• Co-Investigator(Kenkyū-buntansha): YOSHINO Tasashi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70183704) ; OUCHIDA Mamoru 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (80213635) ; 佐藤 妃映 岡山大学, 大学院・保健学研究科, 助教 (70362960)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: ATL / マイクロアレイ / エピジェネテイックス / miRNA / ポリコーム / ヒストン修飾 / DNAメチル化 / 悪性リンパ腫 / エピジェネティックス / 白血病 / ATLL / HTLV-I / メチル化

Research Abstract

We investigated the epigenetic mechanism of onset and progression of non-Hodgikinlymphoma as well as adult T-cell leukemia/lymphoma (ATLL). We found that epigenetic abnormalities including unbalanced expression of Polycomb Repressive Complex (PRC) molecules, aberrant expression of miRNA and mRNA and also aberrant DNA methylation are playing the important role in the pathogenesis of ATLL.

Research Products

• [Journal Article] Duodenal follicular lymphoma lacks AID but expresses BACH2 and has memory B-cell characteristics. (2013)
  • Author(s): Katsuyoshi Takata, Takashi Oka, et al.
  • Journal Title: Modern Pathology Volume: 26 Pages: 22-31
  • NAID: 120005317246
  • Peer Reviewed
• [Journal Article] IL-17A receptor expression differs between subclasses of Langerhans cell histiocytosis, which might settle the IL-17A controversy. (2012)
  • Author(s): Murakami I, Morimoto A, Oka T, Kuwamoto S, Kato M, Horie Y, Hayashi K, Gogusev J, Jaubert F, Imashuku S, Al-Kadar LA, Takata K, Yoshino T
  • Journal Title: Virchows Arch Volume: 462(2) Pages: 219-228
  • Peer Reviewed
• [Journal Article] Dynamic changes of epigenetic abnormalities during initiation and progression of adult T-cell leukemia/lymphoma (ATLL) (2012)
  • Author(s): Takashi Oka, Lamia Abd Al-Kader, Hiaki Sato, Kana Washio, Yoko Shinnou, Katsuyoshi Takata, Ichiro Murakami, Atae Utsunomiya, and Tadashi Yoshino
  • Journal Title: Cancer Research Volume: 72 Pages: 3132-3132
  • Peer Reviewed
• [Journal Article] Duodenal follicular lymphoma lacks AID but expresses BACH2 and has memory B-cell characteristics (2012)
  • Author(s): Katsuyoshi Takata, Yasuharu Sato, Naoya Nakamura, Mami Tokunaka, Yukari Miki,Yara Yukie Kikuti2, Kazuhiko Igarashi4, Etsuro Ito, Hideo Harigae, Seiichi Kato,Eiko Hayashi, Takashi Oka, Yoshinobu Hoshii, Akira Tari, Hiroyuki Okada,Abd Alkader Lamia Mohamad, Yoshinobu Maeda, Mitsune Tanimoto,Tomohiro Kinoshita and Tadashi Yoshino
  • Journal Title: Modern Pathology Volume: 26 Pages: 22-31
  • NAID: 120005317246
  • Peer Reviewed
• [Journal Article] Upregulation of Ezh2 expression correlates with higher tumor proliferation and grade in non-Hodgkin's B- and T-cell lymphoma (2012)
  • Author(s): Lamia Abd Al-Kader, Takashi Oka,Katsuyoshi Takata, Xu Sun, Hiaki Sato, Ichiro Murakami, Hiroshi Kimura, Arie P. Otte, and Tadashi Yoshino
  • Journal Title: Cancer Research Volume: 72 Pages: 1034-1034
  • Peer Reviewed
• [Journal Article] Dynamic changes of epigenetic abnormalities during initiation and progression of adult T-cell leukemia/lymphoma (ATLL) (2012)
  • Author(s): Takashi Oka, Lamia Abd Al-Kader, Hiaki Sato, Kana Washio, et al.
  • Journal Title: Cancer Research Volume: 72 Pages: 3132-3132
  • Peer Reviewed
• [Journal Article] Upregulation of Ezh2 expression correlates with higher tumor proliferation and grade in non-Hodgkin's B- and T-cell lymphoma. (2012)
  • Author(s): Lamia Abd Al-Kader, Takashi Oka, Katsuyoshi Takata, et al.
  • Journal Title: Cancer Research Volume: 72 Pages: 1034-1034
  • Peer Reviewed
• [Journal Article] Tyrosine phosphatase SHP-1 is expressed higher in multisystem than in single-system Langerhans cell histiocytosis by immunohistochemistry (2011)
  • Author(s): Murakami I, Oka T, Kuwamoto S, Kato M, Hayashi K, Gogusev J, Imamura T, Morimoto A, Imashuku S, Yoshino T
  • Journal Title: Virchows Arch Volume: 459 Pages: 2276-234
  • Peer Reviewed
• [Journal Article] Effect of Risedronate on Osteoblast Differentiation, Expression of Receptor Activator of NF-jB Ligand and Apoptosis in Mesenchymal Stem Cells (2011)
  • Author(s): Hirofumi Fujita, Kazuko Kurokawa, Tetsuya Ogino, Mio Ono, Masanao Yamamoto, Takashi Oka, Tohru Nakanishi
  • Journal Title: Basic Clin Pharmacol Toxicol Volume: 109 Pages: 78-84
  • Peer Reviewed
• [Journal Article] Downregulation of the B-cell receptor signaling component CD79b in plasma cell myeloma: A possible post transcriptional regulation. (2011)
  • Author(s): Huang X, Takata K, Sato Y, Tanaka T, Ichimura K, Tamura M, Oka T, Yoshino T
  • Journal Title: Pathol Int Volume: 61 Pages: 122-129
  • NAID: 10031185060
  • Peer Reviewed
• [Journal Article] Cumulative Epigenetic Abnormalities in Host Genes with Viral and Microbial Infection during Initiation and Progression of Malignant Lymphoma/Leukemia. (2011)
  • Author(s): Takashi Oka, Hiaki Sato, Mamoru Ouchida, Atae Utsunomiya and Tadashi Yoshino
  • Journal Title: Cancers Volume: 3 Pages: 568-581
  • Peer Reviewed
• [Journal Article] Downregulation of the B-cell receptor signaling component CD79b in plasma cell myeloma : A possible post transcriptional regulation (2011)
  • Author(s): Huang X, Takata K, Sato Y, Tanaka T, Ichimura K, Tamura M, Oka T, Yoshino T
  • Journal Title: Pathol Int Volume: 61 Pages: 122-129
  • NAID: 10031185060
  • Peer Reviewed
• [Journal Article] Cumulative Epigenetic Abnormalities in Host Genes with Viral and Microbial Infection during Initiation and Progression of Malignant Lymphoma/Leukemia (2011)
  • Author(s): Takashi Oka, Hiaki Sato, Mamoru Ouchida, Atae Utsunomiya, Tadashi Yoshino
  • Journal Title: Cancers Volume: 3 Pages: 568-581
  • Peer Reviewed
• [Journal Article] Effect of Risedronate on Osteoblast Differentiation, Expression of Receptor Activator of NF-jB Ligand and Apoptosis in Mesenchymal Stem Cells. (2011)
  • Author(s): Hirofumi Fujital, Kazuko Kurokawal, Tetsuya Ogino2, Mio Onol, Masanao Yamamotol Takashi Oka3, Tohru Nakanishi4.
  • Journal Title: Basic Clin Pharmacol Toxicol. Volume: doi:10.1111/j.1742-7843-2011.00685.x.[Epub ahead of print]
  • Peer Reviewed
• [Journal Article] Downregulation of the B-cell receptor signaling component CD79b in plasma cell myeloma : A possible post transcriptional regulation. (2011)
  • Author(s): Huang X, Takata K, Sato Y, Tanaka T, Ichimura K, Tamura M, Oka T, Yoshino T.
  • Journal Title: Pathol Int. Volume: 61(3) Pages: 122-129
  • NAID: 10031185060
  • Peer Reviewed
• [Journal Article] Multi-step aberrant CpG island hyper-methylation is associated with the progression of adult T-cell leukemia/lymphoma (ATLL). (2010)
  • Author(s): Hiaki Sato, Takashi Oka, Yoko Shinnou, Takami Kondo, Kana Washio, Masayuki Takano, Katsuyoshi Takata, Toshiaki Morito, Xingang_Huang, Maiko Tamura, Yuta Kitamura, Nobuya Ohara, Mamoru Ouchida, Koichi Ohshima, Kenji Shimizu, Mitsune Tanimoto, Kiyoshi Takahashi, Masao Matsuoka, Atae Utsunomiya, Tadashi Yoshino
  • Journal Title: Ame.J Pathol Volume: 176(1) Pages: 402-415
  • Peer Reviewed
• [Journal Article] Effect of Risedronate on Osteoblast Differentiation,Expression of Receptor Activator of NF-jB Ligand and Apoptosis in Mesenchymal Stem Cells (2010)
  • Author(s): Saito N, Nakatani Y, Oka T, Ohshima K, Takashita M, Iwasaki H and Ikeda S
  • Journal Title: Med.Bull.Fukuoka Univ Volume: 37(1) Pages: 31-37
  • Peer Reviewed
• [Journal Article] Methylation of the thyrosine phosphatase SHP1 gene and loss of its protein in thyroid B-cell lymphoma. (2010)
  • Author(s): Saito N, Nakatani Y, Oka T, Ohshima K, Takashita M, Iwasaki H, Ikeda S.
  • Journal Title: Med.Bull.Fukuoka Univ. Volume: 37(1) Pages: 31-37
  • NAID: 110007523056
  • Peer Reviewed
• [Presentation] ポリコーム群(PcG) 蛋白の異常発現とnon-Hodgkin lymphoma の増殖性と悪性度, 「抗感受性悪性腫瘍に対する標準治療確率のための他施設共同研究」班 (飛内班)の「難治性リンパ腫小班」(木下班) (2012)
  • Author(s): 岡 剛史、Lamia Abd Al-Kader、高田尚良、孫 旭、佐藤妃映、村上一郎、都地友紘、真鍋明広、木村宏、Otte AP,吉野正
  • Organizer: 平成24年度班会議
  • Place of Presentation: 名古屋
  • Year and Date: 2012-12-01
• [Presentation] 十二指腸濾胞性リンパ腫のメチル化解析と発症機構の解析 (2012)
  • Author(s): 高田尚良、岡 剛史、中村直哉、吉野 正
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] Tumor proliferation index Ki67 correlates with PcG2 protein Ezh2 expression in non-Hodgkin lymphoma (2012)
  • Author(s): Lamia ABD AL-Kader、Oka Takashi、Sun Xu、Takata katsuyoshi、Sato Hiaki、Murakami Ichiro、Toji tomohiro、Manabe akihiro、Kimura hiroshi、Otte AP、Yoshino Tadashi
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] 成人T細胞白血病・リンパ腫(ATLL)の発症・進展におけるエピジェネテイックス異常のダイナミックス (2012)
  • Author(s): Takashi Oka,Hirofumi Fujita, Lamia Abd Al-Kader, Hiaki Sato, Ichiro Murakami, Atae Utsunomiya and Tadashi Yoshino
  • Organizer: HTLV-1研究会2012
  • Place of Presentation: 東京
• [Presentation] Aberrant expression of hsa-miR34a in leukemic cells of adult T-cell leukemia/lymphoma (ATL) (2012)
  • Author(s): 岡 剛史、ABD AL-Kader Lamia、佐藤妃映、神農陽子、鷲尾佳奈、村上一郎、大内田守、宇都宮與、吉野 正
  • Organizer: リンパ網内系学会2012
  • Place of Presentation: 福島
• [Presentation] Aberrant expression of Ezh2 correlates with tumor proliferation and signals a more aggressive nature in non Hodgkin lymphoma (2012)
  • Author(s): Lamia Abd Al-Kader, Takashi Oka,Katsuyoshi Takata, Hiaki Sato, Ichiro Murakami, Tomohiro Toji, Akihiro Manabe, Hiroshi Kimura, and Tadashi Yoshino
  • Organizer: リンパ網内系学会2012
  • Place of Presentation: 福島
• [Presentation] Upregulation of Ezh2 expression Correlates with Grade in Non Hodgkin Lymphoma (2012)
  • Author(s): Lamia Abd Al-Kader, Takashi Oka, Katsuyoshi Takata, Xu Sun, Hiaki Sato, Ichiro Murakami, Tomohiro Toji, Hiroshi Kimura, Otte AP and Tadashi Yoshino
  • Organizer: 第101回日本病理学会
  • Place of Presentation: 東京
• [Presentation] ランゲルハンス細胞組織球症(LCH)におけるIL-17R の検討 (2012)
  • Author(s): 村上一郎、岡 剛史、桑本聡史、加藤雅子、林 一彦、吉野 正
  • Organizer: 第101回日本病理学会
  • Place of Presentation: 東京
• [Presentation] 十二指腸濾胞性リンパ腫の発症機構とエビジェネティクス解析 (2012)
  • Author(s): 高田尚良、岡 剛史、安藤 翠、都地 友紘、佐藤 康晴、中村 直哉、吉野 正
  • Organizer: 第101回日本病理学会
  • Place of Presentation: 東京
• [Presentation] 成人T細胞白血病・リンパ腫(ATTL)の発症・進展におけるエビジェネティックス異常の動態解析 (2012)
  • Author(s): 岡 剛史、ABD AL-Kader Lamia、佐藤妃映、神農陽子、鷲尾佳奈、高田尚良、村上一郎、大内田守、大島孝一、宇都宮與、吉野 正
  • Organizer: 第101回日本病理学会
  • Place of Presentation: 東京
• [Presentation] Dynamic changes of epigenetic abnormalities during initiation and progression of adult T-cell leukemia/lymphoma (ATLL) (2012)
  • Author(s): Takashi Oka*, Lamia Abd Al-Kader, Hiaki Sato, Kana Washio, Yoko Shinnou, Katsuyoshi Takata, Ichiro Murakami, Atae Utsunomiya, Mamoru Ouchida and Tadashi Yoshino
  • Organizer: American Association of Cancer Research (AACR) Annual Meeting 2012
  • Place of Presentation: Chicago, Illinois, USA
• [Presentation] Upregulation of Ezh2 expression Correlates with Higher Tumor Proliferation and Grade in Non Hodgkin B and T Cell Lymphoma (2012)
  • Author(s): Lamia Abd Al-Kader, Takashi Oka, Katsuyoshi Takata, Xu Sun, Hiaki Sato, Ichiro Murakami, Hiroshi Kimura, Otte AP and Tadashi Yoshino
  • Organizer: American Association of Cancer Research (AACR) Annual Meeting 2012
  • Place of Presentation: Chicago, Illinois, USA
• [Presentation] Identification and profiling of aberrantly expressed microRNAs during progression of adult T-cell leukemia/lymphoma (ATLL) (2012)
  • Author(s): Takashi Oka, Yuta Kitamura, Maiko Tamura, Hiaki Sato, Kana Washio,Lamia Abd Al-Kader, Mamoru Ouchida, Atae Utsunomiya and Tadashi Yoshino
  • Organizer: The 5th International Symposium for Future Technology Creating Better Human Health and Society Comprehensive Approach to Cancer and Infectious Diseases
  • Place of Presentation: Okayama, Japan
• [Presentation] ランゲルハンス細胞組織球症（LCH）におけるIL-17Rの検討 (2012)
  • Author(s): 村上一郎、岡 剛史、桑本聡史、加藤雅子、林 一彦、吉野 正
  • Organizer: 第１０１回日本病理学会
  • Place of Presentation: 東京
• [Presentation] Upregulation of Ezh2 expression Correlates with Grade in Non Hodgkin Lymphoma (2012)
  • Author(s): Lamia Abd Al-Kader, Takashi Oka, Katsuyoshi Takata, Xu Sun, Hiaki Sato, Ichiro Murakami, Tomohiro Toji, Hiroshi Kimura, Otte AP and Tadashi Yoshino
  • Organizer: 第１０１回日本病理学会
  • Place of Presentation: 東京
• [Presentation] 成人T細胞白血病・リンパ腫（ATTL）の発症・進展におけるエビジェネティックス異常の動態解析 (2012)
  • Author(s): 岡 剛史、ABD AL-Kader Lamia、佐藤妃映、神農陽子、鷲尾佳奈、高田尚良、村上一郎、大内田守、大島孝一、宇都宮與、吉野 正
  • Organizer: 第１０１回日本病理学会
  • Place of Presentation: 東京
• [Presentation] 十二指腸濾胞性リンパ腫の発症機構とエビジェネティクス解析 (2012)
  • Author(s): 高田尚良、岡 剛史、安藤 翠、都地 友紘、佐藤 康晴、中村 直哉、吉野 正
  • Organizer: 第１０１回日本病理学会
  • Place of Presentation: 東京
• [Presentation] Aberrant expression of Ezh2 correlates with tumor proliferation and signals a more aggressive nature in non Hodgkin lymphoma (2012)
  • Author(s): Lamia Abd Al-Kader, Takashi Oka, Katsuyoshi Takata, Hiaki Sato, Ichiro Murakami, Tomohiro Toji, Akihiro Manabe, Hiroshi Kimura, and Tadashi Yoshino
  • Organizer: リンパ網内系学会２０１２
  • Place of Presentation: 福島
• [Presentation] Aberrant expression of hsa-miR34a in leukemic cells of adult T-cell leukemia/lymphoma (ATL) (2012)
  • Author(s): 岡 剛史、ABD AL-Kader Lamia、佐藤妃映、神農陽子、鷲尾佳奈、村上一郎、大内田守、宇都宮與、吉野 正
  • Organizer: リンパ網内系学会２０１２
  • Place of Presentation: 福島
• [Presentation] Tumor proliferation index Ki67 correlates with PcG2 protein Ezh2 expression in non-Hodgkin lymphoma (2012)
  • Author(s): Lamia ABD AL-Kader、 Oka takashi、Sun Xu、Takata katsuyoshi、Sato Hiaki、Murakami Ichiro、Toji tomohiro、Manabe akihiro、Kimura hiroshi、Otte AP、Yoshino Tadashi
  • Organizer: 第7１回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] 成人Ｔ細胞白血病・リンパ腫(ATLL)の発症・進展におけるエピジェネテイックス異常のダイナミックス (2012)
  • Author(s): Takashi Oka, Hirofumi Fujita, Lamia Abd Al-Kader, Hiaki Sato, Ichiro Murakami, Atae Utsunomiya and Tadashi Yoshino
  • Organizer: HTLV-1研究会2012
  • Place of Presentation: 東京
• [Presentation] 十二指腸濾胞性リンパ腫のメチル化解析と発症機構の解析 (2012)
  • Author(s): 高田尚良、岡 剛史、中村直哉、吉野 正
  • Organizer: 第7１回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] Identification and profiling of aberrantly expressed microRNAs during progression of adul't T-cell leukemia/lymphoma (ATLL) (2012)
  • Author(s): Takashi Oka, Yuta Kitamura, Maiko Tamura, Hiaki Sato, Kana Washio, Lamia Abd Al-Kader, Mamoru Ouchida, Atae Utsunomiya, Tadashi Yoshino
  • Organizer: The 5th International Symposium for Future Technology Creating Better Human Health and Society Comprehensive Approach to Cancer and Infectious Diseases
  • Place of Presentation: Okayama, Japan
• [Presentation] Multi-step accumulation of aberrant CpG island hypermethylation in specific genes promotes development and progression of lymphomas/leukemias (2011)
  • Author(s): Takashi Oka
  • Organizer: Invited Lecture at University of Amsterdam
  • Place of Presentation: Amsterdam, Netherland
  • Year and Date: 2011-06-10
• [Presentation] Cumulative aberrant methylation in specific genes during progression of Adult T-cell Leukemia/Lymphoma (ATLL) (2011)
  • Author(s): Takashi Oka, Hiaki Sato, Lamia Abd Al-Kader, Yoko Shinnou, Kana Washio, Ichiro Murakami, Atae Utsunomiya, Mamoru Ouchida, and Tadashi Yoshino
  • Organizer: The 4th International Symposium for Future Technology Creating Better Human Health and Society. Comprehensive Approach to Cancer and Infectious Diseases
  • Place of Presentation: Okayama
  • Year and Date: 2011-02-08
• [Presentation] Cumulative aberrant methylation in specific genes during progression of Adult T-cell Leukemia/Lymphoma (ATLL) (2011)
  • Author(s): Takashi Oka1), Hiaki Sato2), Lamia Abd Al-Kader1), Yoko Shinnou1), Kana Washio1), Ichiro Murakami4), Atae Utsunomiya5), Mamoru Ouchida3), Tadashi Yoshino1)
  • Organizer: The 4th International Symposium for Future Technology Creating Better Human Health and Society Comprehensive Approach to Cancer and Infectious Diseases
  • Place of Presentation: Okayama
  • Year and Date: 2011-02-08
• [Presentation] 超微量検体による悪性リンパ腫・白血病の早期発見・診断・高感度病態モニタリング技術の開発 (2011)
  • Author(s): 岡 剛史
  • Organizer: Bio Japan 2011
  • Place of Presentation: Tokyo
• [Presentation] 成人T細胞白血病(ATLL)の進展に於けるエピジェネティック状態の動的変化 (2011)
  • Author(s): 岡 剛史、佐藤妃映、Lamia ABD AL-Kader、村上一郎、高田尚良、宇都宮與、大内田守、吉野 正
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] 悪性リンパ腫に於けるEzh2の異常発現;aggressivenessとの関連 (2011)
  • Author(s): Lamia ABD AL-Kader、岡 剛史、高田尚良、佐藤妃映、村上一郎、吉野 正
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] B細胞リンパ腫におけるCD79b発現の検討 (2011)
  • Author(s): 黄 新剛、高田尚良、田中健大、岡 剛史、吉野 正
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] Aberrant expression of PcG proteins in Non-Hodgkin B- and T-Cell Lymphoma: A relation to aggressive sub-types (2011)
  • Author(s): Lamia Abd Al-Kader, Takashi Oka, Katsuyoshi Takata, Xu Sun, Hiaki Sato, Akihiro Manabe, Tomohiro Toji, Ichiro Murakami, Mamoru Ouchida,Hiroshi Kimura, Otte AP and Tadashi Yoshino
  • Organizer: The XXV Symposium of the International Association for Comparative Research on Leukemia and Related Diseases
  • Place of Presentation: Tokyo, Japan
• [Presentation] Clonal Epigenetic Changes in Specific Genes during Progression of Adult T-cell Leukemia/Lymphoma (ATLL) (2011)
  • Author(s): Takashi Oka,Lamia Abd Al-Kader, Hiaki Sato, Yoko Shinnou, Kana Washio, Ichiro Murakami, Atae Utsunomiya, Mamoru Ouchida, and Tadashi Yoshino
  • Organizer: XV International Congress of Virology
  • Place of Presentation: Sapporo, Japan
• [Presentation] 成人T細胞白血病・リンパ腫(ATLL)の発症・進展におけるエピジェネテイックス異常 (2011)
  • Author(s): 岡 剛史、佐藤妃映、ABD AL-Kader Lamia、神農陽子、鷲尾佳奈、高田尚良、田村麻衣子、村上一郎、大内田守、大島孝一、宇都宮與、吉野 正
  • Organizer: 日本リンパ網内系学会
  • Place of Presentation: 福岡
• [Presentation] Cumulative kinetics of epigenetic abnormalities during initiation and progression of Adult T-cell Leukemia/Lymphoma (ATLL) (2011)
  • Author(s): Takashi Oka, Hiaki Sato, Lamia Abd Al-Kader, Yoko Shinnou, Kana Washio, Katsuyoshi Takata, Ichiro Murakami, Atae Utsunomiya, Mamoru Ouchida, Kiyoshi Takahashi and Tadashi Yoshino
  • Organizer: 15th International Conference on Human Retrovirology: HTLV and Related Retroviruses
  • Place of Presentation: Leuven, Belgium
• [Presentation] 成人T細胞白血病・リンパ腫(ATLL)の発症・進展におけるエピジェネテイックス異常の解析 (2011)
  • Author(s): 岡 剛史、佐藤妃映、ABD AL-Kader Lamia、神農陽子、鷲尾佳奈、高田尚良、田村麻衣子、村上一郎、大内田守、大島孝一、宇都宮與、高橋聖之、吉野 正
  • Organizer: 日本病理学会2011
  • Place of Presentation: 横浜
• [Presentation] HTLV-1キャリアにおけるDNA メチル化の解析 (2011)
  • Author(s): 佐藤妃映、岡 剛史、ABD AL-Kader Lamia、神農陽子、鷲尾佳奈、高田尚良、田村麻衣子、村上一郎、大内田守、大島孝一、宇都宮與、高橋聖之、吉野 正
  • Organizer: 日本病理学会2011
  • Place of Presentation: 横浜
• [Presentation] PTPN6(SHP-1)遺伝子導入Langerhans cell 様細胞株(ELD-1)に 関する検討 (2011)
  • Author(s): 村上一郎、岡 剛史、桑本聡史、加藤雅子、堀江 靖、林 一彦、佐藤妃映、高橋聖之、吉野 正
  • Organizer: 日本病理学会2011
  • Place of Presentation: 横浜
• [Presentation] 消化管follicular lymphomaの病理組織学的検索(十二指腸下行脚での特異性) (2011)
  • Author(s): 高田尚良、佐藤康晴、岡 剛史、中村直哉、吉野 正
  • Organizer: 日本病理学会2011
  • Place of Presentation: 横浜
• [Presentation] 成人T細胞白血病/リンパ腫(ATLL)におけるDNAメチル化と病態との関連 (2011)
  • Author(s): 平岩千尋、岡 剛史、佐藤妃映、 AL-Kader Lamia、神農陽子、鷲尾佳奈、佐藤康晴、高田尚良、田村麻衣子、村上一郎、大内田守、大島孝一、宇都宮與、吉野 正
  • Organizer: 日本病理学会2011
  • Place of Presentation: 横浜
• [Presentation] 成人T細胞白血病・リンパ腫(ATLL)の発症・進展におけるエピジェネティックス異常の解析 (2011)
  • Author(s): 岡剛史、佐藤妃映、ABD AL-Kader Lamia、神農陽子、鷲尾佳奈、高田尚良、田村麻衣子、村上一郎、大内田守、大島孝一、宇都宮興、高橋聖之、吉野正
  • Organizer: 日本病理学会2011
  • Place of Presentation: 横浜
• [Presentation] HTLV-1キャリアにおけるDNAメチル化の解析 (2011)
  • Author(s): 佐藤妃映、岡剛史、ABD AL-Kader Lamia、神農陽子、鷲尾佳奈、高田尚良、田村麻衣子、村上一郎、大内田守、大島孝一、宇都宮興、高橋聖之、吉野正
  • Organizer: 日本病理学会2011
  • Place of Presentation: 横浜
• [Presentation] PTPN6(SHP-1)遺伝子導入Langerhans cell様細胞株(ELD-1)に関する検討 (2011)
  • Author(s): 村上一郎、岡剛史、桑本聡史、加藤雅子、堀江靖、林一彦、佐藤妃映、高橋聖之、吉野正
  • Organizer: 日本病理学会2011
  • Place of Presentation: 横浜
• [Presentation] EZH2 is up-regulated in aggressive subtypes of non Hodgkin B and T cell lyraphoma (2011)
  • Author(s): Lamia Abd Al-Kader, Takashi Oka, Katsuyoshi Takata, Hiaki Sato, Ichiro Murakami, Tadashi Yoshino
  • Organizer: 日本病理学会2011
  • Place of Presentation: 横浜
• [Presentation] 成人T細胞白血病・リンパ腫(ATLL)の発症・進展におけるエピジェネティックス異常 (2011)
  • Author(s): 岡剛史、佐藤妃映、ABD AL-Kader Lamia、神農陽子、鷲尾佳奈、高田尚良、田村麻衣子、村上一郎、大内田守、大島孝一、宇都宮與、吉野正
  • Organizer: 日本リンパ網内系学会
  • Place of Presentation: 福岡
• [Presentation] Cumulative kinetics of epigenetic abnormalities during initiation and progression of Adult T-cell Leukemia/Lymphoma (ATLL) (2011)
  • Author(s): Takashi Oka, Hiaki Sato, Lamia Abd Al-Kader, Yoko Shinnou, Kana Washio, Katsuyoshi Takata, Ichiro Murakami, Atae Utsunomiya, Mamoru Oucchida, Kiyoshi Takahashi, Tadashi Yoshino
  • Organizer: 15th International Conference on Human Retrovirology : HTLV and Related Retroviruses
  • Place of Presentation: ベルギー、ルーベン
• [Presentation] 悪性リンパ腫に於けるEzh2の異常発現; aggressivenessとの関連 (2011)
  • Author(s): Lamia ABD AL-Kader、岡剛史、高田尚良。佐藤妃映、村上一郎、吉野正
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] B細胞リンパ腫におけるCD79b発現の検討 (2011)
  • Author(s): 黄新剛、高田尚良、田中健大、岡剛史、吉野正
  • Organizer: 第70回日本癌学会字術総会
  • Place of Presentation: 名古屋
• [Presentation] Clonal Epigenetic Changes in Specific Genes during Progression of Adult T-cell Leukemia/Lyraphoma (ATLL) (2011)
  • Author(s): Takashi Oka, Lamia Abd Al-Kader, Hiaki Sato, Yoko Shinnou, Kana Washio, Ichiro Murakami, Atae Utsunomiya, Mamoru Ouchida, Tadashi Yoshino
  • Organizer: XV International Congress of Virology
  • Place of Presentation: Sapporo, Japan
• [Presentation] Aberrant expression of PcG proteins in Non-Hodgkin B- and T-Cell Lymphoma : A relation to aggressive sub-types (2011)
  • Author(s): Lamia Abd Al-Kader, Takashi Oka, Katsuyoshi Takata, Xu Sun, Hiaki Sato, Akihiro Manabe, Tomohiro Toji, Ichiro Murakami, Mamoru Ouchida, Hiroshi Kimura, Otte AP, Tadashi Yoshino
  • Organizer: The XXV Symposium of the International Association for Comparative Research on Leukemia and Related Diseases
  • Place of Presentation: Tokyo
• [Presentation] 成人T細胞白血病・リンパ腫(ATLL)の発症・進展におけるEpigenetics異常の解析 (2010)
  • Author(s): 岡 剛史、佐藤妃映、ABD AL-Kader Lamia、宇都宮 與、吉野 正
  • Organizer: 第二回木下班会議
  • Place of Presentation: 名古屋
  • Year and Date: 2010-11-23
• [Presentation] 間葉系幹細胞の特異的分化に関与するエピジェネティック制御遺伝子の網羅的解析 (2010)
  • Author(s): 岡 剛史、高野正幸、姜 頚哲、神農陽子、鷲尾佳奈、北村雄太、佐藤妃映、村上一郎、中西徹、吉野 正
  • Organizer: 硬組織再生生物学会
  • Place of Presentation: 岡山
  • Year and Date: 2010-09-04
• [Presentation] 間葉系幹細胞の分化に関与するエピジェネティック制御遺伝子の網羅的解析 (2010)
  • Author(s): 岡剛史1)、高野正幸1)、姜頚哲1)、神農陽子1)、鷲尾佳奈1)、北村雄太1)、佐藤妃映1,2)、村上一郎3)、中西徹4)、吉野正1)
  • Organizer: 硬組織再生生物学会
  • Place of Presentation: 岡山
  • Year and Date: 2010-09-04
• [Presentation] Development and progression of gastric MALT lymphoma are associated with accumulation of specific aberrant CpG hypermethylation by Helicobacter pylori infection. (2010)
  • Author(s): Takashi Oka,Takami Kondo, Hiaki Sato, Yoko Shinnou, Kana Washio, Ichirou Murakamni, ABD AL-Kader Lamia, Xu Sun, Katsuyoshi Takata, Mamoru Ohuchidaand Tadashi Yoshino
  • Organizer: Epigenetics研究会
  • Place of Presentation: 米子
  • Year and Date: 2010-05-28
• [Presentation] Development and progression of gastric MALT lymphoma are associated with accumulation of specific aberrant CpG hypermethylation by Helicobacter pylori infection (2010)
  • Author(s): Takashi Oka1), Takami Kondo1), Hiaki Sato3), Yoko Shinnou1), Kana Washio1), Ichirou Murakamni1), ABD AL-Kader Lamia1), Xu Sun1), Katsuyoshi Takata1), Mamoru Ohuchida2), Tadashi Yoshino1)
  • Organizer: Epigenetics研究会
  • Place of Presentation: 米子
  • Year and Date: 2010-05-28
• [Presentation] TNF-アルファによるは骨細胞分化に対するヒト間養鶏肝細胞とリセドロナートの影響 (2010)
  • Author(s): 斧美緒、藤田洋史、岡 剛史、中西徹、山本昌直、内海耕造、久保田敏夫、佐々木順造
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] Multi-step accumulation of aberrant CpG island hypermethylation during progression of lymphoma/leukemia (2010)
  • Author(s): Takashi Oka, Takami Kondo, Hiaki Sato, Yoko Nakatani, Kana Washio, Ichiro Murakami, Nobuya Ohara, Kiyoshi Takahashi, Mamoru Ouchida,Mitsune Tanimoto,Tadashi Yoshino
  • Organizer: 15th World Congress on Advances in Oncology, 13th International Symposium on Molecular Medicine
  • Place of Presentation: Loutraki, Greece
• [Presentation] Accumulation of aberrant CpG hypermethylation in specific genes induce development and progression of MALT lymphoma (2010)
  • Author(s): Takashi Oka, Takami Kondo, Hiaki Sato, Yoko Shinnou, Kana Washio, Ichirou Murakamni, ABD AL-Kader Lamia, Xu Sun, Katsuyoshi Takata, Mamoru Ohuchidaand Tadashi Yoshino
  • Organizer: 日本癌学会
  • Place of Presentation: 大阪
• [Presentation] Down -regulation of BCR signaling component CD79b in plasma cell myeloma: potential post-transcriptional mechanism (2010)
  • Author(s): X Huang, K Takata, K Tanaka, K Ichimura, T Oka, and T Yoshino
  • Organizer: 日本癌学会
  • Place of Presentation: 大阪
• [Presentation] Aberrant expression of Polycomb Group (PcG) gene:Bmi-1 in malignant lymphoma (2010)
  • Author(s): Xu Sun, Takashi Oka,Katsuyoshi Takata, Hiaki Sato, Xingang Huang, Ichiro Murakami, ABD AL-Kader Lamia , Tadashi Yoshino
  • Organizer: 日本癌学会
  • Place of Presentation: 大阪
• [Presentation] HTLV-1キャリアにおけるDNA異常メチル化と病態との関連 (2010)
  • Author(s): 佐藤妃映、岡 剛史、ABD AL-Kader Lamia, 孫 旭,神農陽子、鷲尾佳奈、高田尚良、田村麻衣子、村上一郎、大内田守、宇都宮與、高橋聖之、吉野 正
  • Organizer: 第3回HTLV研究会
  • Place of Presentation: 東京
• [Presentation] Langerhans cell histiocytosis における活性化型PTPN6(SHP-1)pY536の発現 (2010)
  • Author(s): 村上一郎、岡 剛史、桑本聡、加藤雅子、林 一彦、田村麻衣子、佐藤妃映、北村雄太、鷲尾 佳奈、黄 新剛、高野正幸、守都敏晃、高田尚良、佐藤康晴、神農陽子、田中健大、市村浩一、大原信哉、柳井広之、近藤英作、高橋聖之、吉野 正
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] Langerhans cell histiocytosisにおける活性化型PTPN6(SHP-1)pY536の発現 (2010)
  • Author(s): 村上一郎、岡剛史、桑本聡、加藤雅子、林一彦、田村麻衣子、佐藤妃映、北村雄太、鷲尾佳奈、黄新剛、高野正幸、守都敏晃、高田尚良、佐藤康晴、神農陽子、田中健大、市村浩一、大原信哉、柳井広之、近藤英作、高橋聖之、吉野正
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] Down-regulation of BCR signaling component CD79b in plasm cell myeloma : potential post-transcriptionl mechanism (2010)
  • Author(s): X Huang, K Takata, K Tanaka, K Ichimura, T Oka, T Yoshino
  • Organizer: 日本癌学会
  • Place of Presentation: 大阪
• [Presentation] Aberrant expression of Polycomb Group (PcG) gene : Bmi-1 in malignant lymphoma (2010)
  • Author(s): Xu Sun1,3, Takashi Oka1, Katsuyoshi Takata1, Hiaki Sato1,2, Xingang Huang1, Ichiro Murakami1, ABD AL-Kader Lamia1, Tadashi Yoshino1
  • Organizer: 日本癌学会
  • Place of Presentation: 大阪
• [Presentation] TNF-アルファによるは骨細胞分化に対するヒト間養鶏肝細胞とリセドロナートの影響 (2010)
  • Author(s): 斧美緒、藤田洋史、岡剛史、中西徹、山本昌直、内海耕造、久保田敏夫、佐々木順造
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
• [Presentation] 間葉系肝細胞の骨芽細胞分に伴う石灰における細胞死の関与 (2010)
  • Author(s): 藤田洋史、斧美緒、荻野哲也、岡剛史、中西徹、内海耕造、佐々木順造
  • Organizer: 第33回日本分子生物学会・第83回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
• [Presentation] ポリコーム群(PcG)蛋白の異常発現とnon-Hodgkin lymphomaの増殖性と悪性度
  • Author(s): 岡 剛史、Lamia Abd Al-Kader、高田尚良、孫 旭、佐藤妃映、村上一郎、都地友紘、真鍋明広、木村宏、Otte AP，吉野正
  • Organizer: 「抗感受性悪性腫瘍に対する標準治療確率のための他施設共同研究」班 (飛内班)の「難治性リンパ腫小班」（木下班）平成24年度班会議
  • Place of Presentation: 名古屋
• [Book] Accumulation of Specific EpigeneticAbnormalities during Development and Progression of T cell Leukemia/Lymphoma. (2011)
  • Author(s): Takashi Oka,Hiaki Sato, Mamoru Ouchida, Atae Utsunomiya, Daisuke Ennishi, Mitsune Tanimoto, and Tadashi Yoshino
  • Publisher: InTech Press
• [Book] T cell leukemia (2011)
  • Author(s): Takashi Oka, Hiaki Sato, Mamoru
  • Total Pages: 234
  • Publisher: InTech
• [Patent(Industrial Property Rights)] ATLLの診断のためのデータ取得方法、ATLL診断用キットおよびATLL診断システム (2013)
  • Inventor(s): 岡 剛史、大内田 守、吉野 正
  • Industrial Property Rights Holder: 国立大学法人 岡山大学
  • Industrial Property Number: 2013-026614
  • Filing Date: 2013-02-14
• [Patent(Industrial Property Rights)] Test method for MALT lymphoma and kit therefor (2013)
  • Inventor(s): Takashi Oka,Takami Kondo, Tadashi Yoshino, Mamoru Oouchida
  • Industrial Property Rights Holder: National University Corporation Okayama University
  • Acquisition Date: 2013-02-27
  • Overseas
• [Patent(Industrial Property Rights)] ＡＴＬＬの診断のためのデータ取得方法、ＡＴＬＬ診断用キットおよびＡＴＬＬ診断システム (2013)
  • Inventor(s): 岡剛史.大内田守,吉野正
  • Industrial Property Rights Holder: 国立大学法人岡山大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-026614
  • Filing Date: 2013-02-14
• [Patent(Industrial Property Rights)] 高悪性型 ATLL の診断のためのデータ取得方法、高悪性型 ATLL 診断用キット及び高悪性型 ATLL 診断システム (2012)
  • Inventor(s): 岡 剛史、大内田 守、吉野 正
  • Industrial Property Rights Holder: 国立大学法人 岡山大学
  • Industrial Property Number: 2012-029463
  • Filing Date: 2012-02-14
• [Patent(Industrial Property Rights)] MALTリンパ腫の検査方法およびキット (2012)
  • Inventor(s): 岡 剛史、近藤孝美、吉野正、大内田守
  • Industrial Property Rights Holder: 国立大学法人岡山大学
  • Acquisition Date: 2012-06-08
• [Patent(Industrial Property Rights)] 高悪性型ATLLの診断のためのデータ取得方法、高悪性型ATLL診断用キット及び高悪性型ATLL診断システム (2012)
  • Inventor(s): 岡剛史、大内田守、吉野正
  • Industrial Property Rights Holder: 国立大学法人岡山大学
  • Industrial Property Number: 2012-029463
  • Filing Date: 2012-02-14