A role of dbpA, DNA binding protein in Hodgkin lymphoma

• Project/Area Number: 22590338
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Juntendo University
• Principal Investigator: MOMOSE Shuji 順天堂大学, 医学部, 非常勤講師 (70360344)
• Co-Investigator(Kenkyū-buntansha): TAMARU Jun-ichi 埼玉医科大学, 医学部, 教授 (30188429) ; 梶野 一徳 順天堂大学, 医学部, 助教 (80260066)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: CD30 / dbpA / リンパ腫 / 病理学 / ｄｂｐA / Hodgkinリンパ腫 / 悪性リンパ腫

Research Abstract

dbpA, DNA-binding protein A is belived to be involved in DNA recombination in E.Coli. We found dbpA is highly expressed in CD30 positive lymphocytes, which is restricted to activated lymphocyte in normal tissue. Also dbpA is highlyexpressed in CD30+lymphoma, classical Hodgkin lymphoma and anaplastic lymphoma. As it is well known that constitutive activation of NF・B signaling is a characteristic feature of Hodgkin lymphoma, dbpA seemed to act in a downstream molecule of NF・B signaling pathway.

Research Products

• [Journal Article] Expression of Epstein-Barr Virus-Encoded Proteins in Extranodal NK/T-cell Lymphoma, Nasal Type (ENKL): Differences in Biologic and Clinical Behaviors of LMP1-Positive and -Negative ENKL (2012)
  • Author(s): Kanemitsu N, Isobe Y, Masuda A, Momose S, Higashi M, Tamaru J, Sugimoto K, Komatsu N
  • Journal Title: Clin Cancer Res Volume: 18(8) Pages: 2164-72
  • Peer Reviewed
• [Journal Article] Expression of Epstein-Barr Virus-Encoded Proteins in Extranodal NK/T-cell Lymphoma, Nasal Type (ENKL): Differences in Biologic and Clinical Behaviors of LMP1-Positive and -Negative ENKL. (2012)
  • Author(s): Kanemitsu N,
  • Journal Title: Clin Cancer Res. Volume: 18（8） Issue: 8 Pages: 2164-2172
  • DOI: 10.1158/1078-0432.ccr-11-2395
  • Peer Reviewed
• [Journal Article] Hodgkinリンパ腫における放射線誘発二次発がんの原因遺伝子の解明 (2012)
  • Author(s): 百瀬修二
  • Journal Title: 血液内科 Volume: 64(4) Pages: 487-491
  • NAID: 40019312386
• [Journal Article] Expression of Epstein-Barr virus-encoded proteins in extranodal NK/T-cell lymphoma, nasal type (ENKL) : Differences in biological and clinical behaviors of LMP1-positive and -negative ENKL (2012)
  • Author(s): Naoko Kanemitsu, et al
  • Journal Title: Clin Cancer Res Volume: 18 Issue: 8 Pages: 2336-2343
  • DOI: 10.1158/1078-0432.ccr-11-2825
  • Peer Reviewed
• [Journal Article] Microscopic polyangitis complicating double carcinoma of the stomach and duodenum: improvement after the resection of these carcinomas (2011)
  • Author(s): be H, Momose S, Takeuchi T
  • Journal Title: Rheumatol Int Volume: 31(1) Pages: 105-8
  • Peer Reviewed
• [Journal Article] Y-box binding protein-1 expression in diffuse large B-cell lymphoma: an impact on prognosis in the rituximab era (2010)
  • Author(s): Hanzawa K, Momose S, Higashi M, Tokuhira M, Watanabe R, Kajino K, Hino O, Itoyama S, Kizaki M, Tamaru J
  • Journal Title: Leuk Lymphoma Volume: 51(11) Pages: 2054-62
  • Peer Reviewed
• [Journal Article] Mesothelin (MSLN) promoter is hypomethylated in malignant mesothelioma, but its expression is not associated with methylation status of the promoter (2010)
  • Author(s): Tan K, Kajino K, Momose S, Masaoka A, Sasahara K, Shiomi K, Izumi H, Abe M, Ohtsuji N, Wang T, Hino O, Fujii H
  • Journal Title: Hum Pathol Volume: 41(9) Pages: 1330-8
  • Peer Reviewed
• [Journal Article] Y-box binding protein-1 expression in diffuse large B-cell lymphoma : an impact on prognosis in the rituximab era. (2010)
  • Author(s): Hanzawa K, Momose S, Higashi M, et al.
  • Journal Title: Leukemia & Lymphoma Volume: 51 Pages: 2054-62
  • Peer Reviewed
• [Journal Article] Mesothelin (MSLN) promoter is hypomethylated in malignant mesothelioma, but its expression is not associated with methylation status of the promoter. (2010)
  • Author(s): Tan K, Kajino K, Momose S, et al
  • Journal Title: Human Pathology Volume: 41 Pages: 1330-38
  • Peer Reviewed
• [Journal Article] 胸水・腹水の病理 胸腹水の生化学的マーカー-最近の知見- (2010)
  • Author(s): 百瀬修二、樋野興夫
  • Journal Title: 病理と臨床 Volume: 28 Pages: 1125-8
• [Presentation] Oral lichen planusとの鑑別に苦慮したcarcinoma in situを伴うlichenoid dysplasiaの1例 (2010)
  • Author(s): 川野竜太郎, 下山哲夫, 百瀬修二, 東守洋, 田丸淳一, 糸山進次
  • Organizer: 第99回日本病理学会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-29
• [Presentation] 「悪性リンパ腫」日常診断において知っておきたい新たな疾患概念ALK陽性大細胞型B細胞性リンパ腫について (2010)
  • Author(s): 百瀬修二
  • Organizer: 第99回日本病理学会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-28
• [Presentation] びまん性大細胞型B細胞性リンパ腫(DLBCL)におけるYB-1の発現と臨床病理学的意義 (2010)
  • Author(s): 半澤京子, 得平道英, 渡部玲子, 森茂久, 木崎昌弘, 百瀬修二, 東守洋, 田丸淳一, 梶野一徳, 樋野興夫, 糸山進次
  • Organizer: 第99回日本病理学会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-28
• [Presentation] 関節リウマチに対する抗TNFα製剤(アダリマブ)投与中に発症した免疫不全関連リンパ増殖性疾患の1例 (2010)
  • Author(s): 正岡亜希子, 百瀬修二, 田丸淳一, 樋野興夫
  • Organizer: 第99回日本病理学会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-28
• [Presentation] 悪性中皮腫におけるMesothelinプロモーター低メチル化状態とその発現状態 (2010)
  • Author(s): 譚珂, 梶野一徳, 百瀬修二, 阿部雅明, 泉浩, 樋野興夫, 藤井博昭
  • Organizer: 第99回日本病理学会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-28
• [Book] 血液内科 第64 巻第4 号 (2012)
  • Author(s): 百瀬修二
  • Publisher: 科学評論社
• [Book] 多発性骨髄腫治療マニュアル 第I章 治療の前に B.骨髄腫細胞の形態学的特徴と細胞表面マーカー (2012)
  • Author(s): 百瀬修二 田丸淳一
  • Total Pages: 7
  • Publisher: 南江堂
• [Book] II.悪性リンパ腫 1.改訂第4 版 (2010)
  • Author(s): 百瀬修二 田丸淳一
  • Publisher: 中外医学社
• [Book] 樋野興夫胸水・腹水の病理 胸腹水の生化学的マーカー -最近の知見-病理と臨牀 (2010)
  • Author(s): 百瀬修二
• [Book] 造血器腫瘍治療 2版 これは困ったぞ、どうしよう! (2010)
  • Author(s): 百瀬修二
  • Total Pages: 361
  • Publisher: 中外医学社
• [Book] 病理と臨床28(11) (2010)
  • Author(s): 百瀬修二、樋野興夫
  • Publisher: 文光堂