Mechanisms of radiation-related pediatric thyroid cancer
| Project/Area Number |
22590344
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | 独立行政法人 国立病院機構 長崎医療センター・臨床研究センター (2012)
Department of Clinical Research, National Hospital Organization Nagasaki Medical Center (2010-2011) |
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Principal Investigator |
ITOU Masahiro 独立行政法人 国立病院機構 長崎医療センター・臨床研究センター, 機能形態研究部, 部長 (30184691)
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| Co-Investigator(Kenkyū-buntansha) |
NAKASHIMA Masahiro 長崎大学, 医歯(薬)学総合研究科, 教授 (50284683)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | Chernobyl / Thyroid cancer / Papillary carcinoma / Childhood / Radiation / Iodine / 甲状腺癌 / 放射線 / チェルノブイリ / 遺伝子不安定 / 低ヨード / 小児甲状腺がん / ret/PTC / 53BP1 / microRNA / BRAF |
|---|
| Research Abstract |
The Chernobyl Tissue Bank has contributed to data/tissue collection and 4,288 cases have been registered. The age at diagnosis and the latency period from exposure to radiation were correlated with tumor morphology and aggressiveness. Low levels of iodine intake seemed to influence the formation of morphology. Specific genetic mutation by radiation injury has not been identified at individual levels.
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Report
(4 results)
Research Products
(45 results)
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[Presentation] チェルノブイリ組織バンクの現状と新たな展開2012
Author(s)
伊東正博, Tatiana Bogdanova, Alexander Abrosimov, Guido Fadda, Jeniffer Hunt, Gerry Thomas, Virginia LiVolsi, 中島正洋、山下俊一
Organizer
第55回日本放射線影響学会
Place of Presentation
仙台
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[Presentation] Pathology review of childhood thyroid cancer around Chernobyl2011
Author(s)
Ito M, Bogdanova T, Abrosimov A, Fadda G, Hunt J, LiVolsi V, Thomas G, Nakashima M, Yamashita S.
Organizer
The 6th International Symposium of Nagasaki University Global COE Program "Global Strategic Center for Radiation Health Risk Control": A New Challenge of Radiation Health Risk Management
Place of Presentation
Nagasaki
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[Presentation] Immunofluorescence analysis of P53-binding protein 1 as a new molecular indicator for malignant potency and genomic instability in thyroid follicular neoplasms2010
Author(s)
Mussazhanova Z,Nakashima M, Saenko V, Naryke Y, Suzuki K, Mitsutake N, Ito M, Nishihara E, Hirokawa M, Yamashita S.
Organizer
第14回国際甲状腺学会
Place of Presentation
パリ, フランス
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