Possible mechanisms of galectin-9-induced immunoregulatory macrophages
Project/Area Number |
22590360
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Experimental pathology
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Research Institution | Kagawa University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
OOMIZU Souichi 香川大学, 医学部, 助教 (00444729)
NIKI Toshiro 香川大学, 医学部, 助教 (40558508)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | ガレクチン 9 / 免疫学 / 癌 / 炎症 / マクロファージ / ガレクチン9 |
Research Abstract |
We described that galectin-9 regulates functions of not only immunocompetent cells but also various cells by collaboration with world-wide investigators. From our works, it is suggested that galectins including galectin-9 play a role as an important factor to overcome stress, because galectins are conserved longtime from fungi and sea sponge to human.
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Report
(4 results)
Research Products
(97 results)
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[Journal Article] Galectin-9 functionally impairs natural killer cells in humans and mice.2013
Author(s)
Golden-Mason L, McMahan RH, Strong M, Reisdorph R, Mahaffey S, Palmer BE, Cheng L, Kulesza C, Hirashima M, Niki T, Rosen HR.
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Journal Title
J Virol
Volume: 87
Pages: 4838-45
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[Journal Article] Tim-3 is an inducible human NK cell receptor that enhances interferon gamma production in response to galectin-92012
Author(s)
MK. Gleason, TR. Lenvik, V. McCullar, M.Felices, MS. O'Brien, SA. Cooley, MR. Verneris, F. Cichocki, CJ. Holman, A.Panoskaltsis-Mortari, T. Niki, M.Hirashima, B.R. Blazar, JS. Miller
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Journal Title
Blood
Volume: 119
Pages: 3064-72
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[Journal Article] Contrasting acute graft-versus-host disease effects ofTim-3/galectin-9 pathway blockade dependent upon the presence ofdonor regulatory T cells.2012
Author(s)
Veenstra RG, Taylor PA, Zhou Q, Panoskaltsis-Mortari A, Hirashima M, Flynn R, Liu D, Anderson AC, Strom TB, Kuchroo VKK, Blazar BR.
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Journal Title
Blood
Volume: 120
Pages: 682-90
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[Journal Article] A novel monoclonal antibody fordetection ofgalectin-9 intissue sections: application tohuman tissues infected byoncogenic viruses.2012
Author(s)
Barjon C, Niki T, Verillaud B, Opolon P, Bedossa P,Hirashima M, Blanchin S, Wassef M, Rosen HR, Jimenez AS, Wei M, Busson P
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Journal Title
Infect Agent Cancer
Volume: 7
Pages: 16-16
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[Journal Article] Tumor-infiltrating DCssuppress nucleic acid-mediated innate immune responses through interactions between thereceptor TIM-3 and thealarmin HMGB1.2012
Author(s)
Chiba S, Baghdadi M, Akiba H, Yoshiyama H, Kinoshita I, Dosaka-Akita H, Fujioka Y, Ohba Y, Gorman JV, Colgan JD, Hirashima M, Uede T, Takaoka A, Yagita H, Jinushi M.
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Journal Title
Nat Immunol
Volume: 13
Pages: 832-42
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[Journal Article] Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1. S.2012
Author(s)
Chiba, M. Baghdadi, H. Akiba, H. Yoshiyama, I. Kinoshita, H. Dosaka-Akita, Y. Fujioka, Y. Ohba, J. V. Gorman, J. D. Colgan, M. Hirashima, T. Uede, A. Takaoka, H. Yagita and M. Jinushi.
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Journal Title
Nat. Immunol.
Volume: 13
Issue: 9
Pages: 832-842
DOI
Related Report
Peer Reviewed
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[Journal Article] Galectin-9 ameliorates acute GVH disease through the induction of T-cell apoptosis2011
Author(s)
Sakai K., Kawata E., Ashihara E., Nakagawa Y., Yamauchi A., Yao H., Nagao R., Tanaka R., Yokota A., Takeuchi M., Hirai H., Kimura S., Hirashima M., Yoshimura N., Maekawa T.
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Journal Title
Eur J Immunol
Volume: 41
Pages: 67-75
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[Journal Article] Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia.2011
Author(s)
Zhou Q, Munger ME, Veenstra RG, Weigel BJ, Hirashima M, Munn DH, Murphy WJ, Azuma M, Anderson AC, Kuchroo VK, Blazar BR.
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Journal Title
Blood
Volume: 117
Pages: 4501-10
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[Journal Article] Galectin-9 attenuates acute lung injury by expanding CD14- plasmacytoid dendritic cell-like macrophages.2011
Author(s)
Kojima K, Arikawa T, Saita N, Goto E, Tsumura S, Tanaka R, Masunaga A, Niki T, Oomizu S, Hirashima M, Kohrogi H.
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Journal Title
Am J Respir Crit Care Med
Volume: 184
Pages: 328-39
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[Journal Article] Galectin-9 expands immunosuppressive macrophages to ameliorate T cell-mediated lung inflammation.2010
Author(s)
Arikawa T, Saita N, Oomizu S, Ueno M, Matsukawa A, Katoh S, Kojima K, Nagahara K, Miyake M, Yamauchi A, Kohrogi H, and Hirashima M.
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Journal Title
Eur J Immunol
Volume: 40
Pages: 548-58
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[Journal Article] Galectin-9 exhibits anti-myeloma activity through JNK and p38 MAP kinase pathways2010
Author(s)
T. Kobayashi, J. Kuroda, E.Ashihara, S. Oomizu, Y. Terui, A. Taniyama, S. Adachi, T. Takagi, M. Yamamoto, N Sasaki, S Horiike, K. Hatake, A. Yamauchi, M.Hirashima, M. Taniwaki.
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Journal Title
Leukemia
Volume: 24
Pages: 843-50
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[Journal Article] Targeting activating transcription factor 3 by galectin-9 induces apoptosis and overcomes various types of treatment resistance in chronic myelogenous leukemia.2010
Author(s)
J. Kuroda, M.Yamamoto, H. Nagoshi, T. Kobayashi, N. Sasaki, Y Shimura, S Horiike, S. Kimura, A. Yamauchi, M. Hirashima, M.Taniwaki.
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Journal Title
Molecular Cancer Research
Volume: 8
Pages: 994-1001
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[Journal Article] Tim-3/galectin-9 pathway: regulation of Th1 immunity through promotion of CD11b+Ly-6G+ myeloid cells., Valerie Dardalhon, AC. Anderson2010
Author(s)
J.Karman, L. Apetoh, R. Chandwaskar, DH. Lee, M.Cornejo, N. Nishi, A. Yamauchi, FJ. Quintana, RA. Sobel, M. Hirashima, VK. Kuchroo.
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Journal Title
J. Immunol.
Volume: 185
Pages: 1383-92
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[Journal Article] A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in chronic hepatitis C infection.2010
Author(s)
John A. Mengshol, Lucy Golden-Mason, Tomohiro Arikawa, Maxwell Smith, Toshiro Niki, Ryan McWilliams, Jessica Randall, Rachel McMahan, Manu Rangachari, Evgenia Dobrinskikh, Pierre Busson, Stephen J. Polyak, Mitsuomi Hirashima, Hugo R. Rosen.
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Related Report
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[Journal Article] Determination of carbohydratebinding preferences of human galectins with carbohydrate microarrays.2010
Author(s)
T.Horlacher, M A. Oberli, DB. Werz, LH. Krock, S. Bufali, B. Stocker, R. Mishra, J. Sobek, K. Simons, M. Hirashima, T. Niki, PH. Seeberger.
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Journal Title
ChemBioChem
Volume: 11
Pages: 1563-73
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