Analysis of physical roles of osteopontin and its cancer-specific molecules in colorectal and pancreatic carcinogenesis
| Project/Area Number |
22590371
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
TAKAHASHI Mami 独立行政法人国立がん研究センター, 研究所, ユニット長 (90214973)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 腫瘍 / オステオポンチン / 膵臓がん / 大腸がん / スプライスバリアント / バイオマーカー |
|---|
| Research Abstract |
Marked elevation of OPNa expression was observed in tumor tissues of chemically-induced colon carcinogenesis model in rats and mice and of pancreatic carcinogenesis models in hamsters and mice. Effect of OPN deficiency on colon carcinogenesis was not evident, but pancreatic cancer incidence and multiplicity were decreased by OPN deficiency in mouse pancreatic carcinogenesis model. The results suggest that OPN is partly involved in cancer development and invasion, and could be a target for cancer prevention.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] A^y allele promotes azoxymethane-induced colorectal carcinogenesis via macrophage migration in hyperlipidemic/diabetic KK mice.2013
Author(s)
Ito, K., Ishigamori, R., Mutoh, M., Ohta, T., Imai, T., Takahashi, M
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Journal Title
Cancer Sci.
Volume: (in press)
Issue: 7
Pages: 835-843
DOI
Related Report
Peer Reviewed
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[Journal Article] Involvement of inflammatory factors in pancreatic carcinogenesis and preventive effects of anti-inflammatory agents.2013
Author(s)
Takahashi, M., Mutoh, M., Ishigamori, R., Fujii, G., Imai, T.
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Journal Title
Semin in Immunopathol,
Volume: 35
Issue: 2
Pages: 203-227
DOI
Related Report
Peer Reviewed
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