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Pathogenic changes of pathogenic bacteriaby catecholamine

Research Project

Project/Area Number 22590393
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Bacteriology (including Mycology)
Research InstitutionThe University of Tokushima

Principal Investigator

TAKAHASHI Akira  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (90304047)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords腸炎ビブリオ / カテコールアミン / 病原性 / ノルエピネフリン / 病原性活性化機構
Research Abstract

Catecholamine, including norepinephrine (NE), has been known as precipitating factor in bacterial infection. The aim of this study was to clarify the pathogenic activation mechanism of pathogenic bacteria that cause the catecholamine, to help infectious diseases treatment.
In this study, we analyzed using Vibrio parahaemolyticushave been studying the applicant is consistently. V.parahaemolyticusinfection can be thought of as an exemplary model of intestinal bacterial infections in general. We searched for the presence of receptors for NE on the surface in V.parahaemolyticus. And we analyzedof the regulatory mechanism and expression pathogenic gene by the NE furtherin V.parahaemolyticus. .

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (15 results)

All 2012 2011 2010 Other

All Journal Article (8 results) (of which Peer Reviewed: 6 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] VopB1 and VopD1 are essential for translocation of type III secretion system 1 effectors of Vibrio parahaemolyticus2012

    • Author(s)
      Takaaki Shimohata, Kazuaki Mawatari, Hitomi Iba, Masakazu Hamano, Sachie Negoro, Shoko Asada, Mutsumi Aihara, Akiko Hirata, Zehong Su andAkira Takahashi
    • Journal Title

      Canadian Journal of Microbiology

      Volume: 58(8) Pages: 1002-1007

    • Related Report
      2012 Final Research Report
  • [Journal Article] VopB1 and VopD1 are essential for translocation of type III secretion system 1 effectors of Vibrio parahaemolyticus.2012

    • Author(s)
      Shimohata T
    • Journal Title

      Can J Microbiol

      Volume: 58 Issue: 8 Pages: 1002-1007

    • DOI

      10.1139/w2012-081

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] VP2118 has major roles in Vibrio parahaemolyticus response to oxidative stress.2012

    • Author(s)
      Le TT
    • Journal Title

      Biochim Biophys Acta

      Volume: 1820 Pages: 1686-1692

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vbrio parahaemolyticusinfection induces modulation of IL-8 secretion through dual pathway via VP1680.2011

    • Author(s)
      Shimohata T., Nakano M., Lian X., Shigeyama T., Iba H., Hamamoto A., Yoshida M., Harada N., Yamato M., Mawatari K., Tamaki T., Nakaya Y., and Takahashi A.
    • Journal Title

      Journal of Infectious Diseases

      Volume: 203 Pages: 537-544

    • Related Report
      2012 Final Research Report
  • [Journal Article] Vbrio parahaemolyticus infection induces inodulation of IL-8 secretion through dual pathway via VP16802011

    • Author(s)
      Shimohata, et al
    • Journal Title

      Journal of Infectious Diseases

      Volume: 203 Pages: 537-544

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hfq regulates anti-oxidative ability in Vbrio parahaemolyticus.2010

    • Author(s)
      Su Z., ほか
    • Journal Title

      J Gen Appl Microbiol.

      Volume: 56 Pages: 181-186

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new colored beverage disinfection system using UV-A light-emitting diodes.2010

    • Author(s)
      Lina X., ほか
    • Journal Title

      Biocontrol Science.

      Volume: 15 Pages: 33-37

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences in stress response after UVC or UVA irradiation in Vibrio parahaemolyticus.2010

    • Author(s)
      Hamamoto A., ほか
    • Journal Title

      Environmental Microbiology Reports

      Volume: 2 Pages: 660-666

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] VP1680 induces IL-8 secretion in Vibrio parahaemolyticus infection2012

    • Author(s)
      下畑 隆明, 射場 仁美, 根来 幸恵, 浅田 翔子, 粟飯原 睦美, 馬渡 一諭, 高 橋 章
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎ブリックホール(長崎県)
    • Year and Date
      2012-03-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 腸炎ビブリオ感染においてVP1680はIL-8の分泌を誘導する2012

    • Author(s)
      高橋章
    • Organizer
      第85回日本細菌学会
    • Place of Presentation
      長崎県(長崎ブリックホール)
    • Year and Date
      2012-03-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Vibrio parahaemolyticusの光回復時酸化ストレス応答の解析2011

    • Author(s)
      高橋章
    • Organizer
      第65回日本栄養・食糧学会大会
    • Place of Presentation
      東京都(お茶の水女子大学)
    • Year and Date
      2011-05-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腸炎ビブリオ感染は腸管上皮細胞においてMAPKsを活性化しIL-8の分泌を誘発する2011

    • Author(s)
      高橋章
    • Organizer
      第85回日本感染症学会総会・学術講演会
    • Place of Presentation
      東京都(ザ・プリンスパークタワー東京)
    • Year and Date
      2011-04-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腸炎ビブリオエフェクタータンパク質 VP1680 は IL-8 の分泌を誘発する2010

    • Author(s)
      下畑 隆明, 中野 政之, 馬渡 一諭, 大和 正幸, 高橋 章
    • Organizer
      第63回日本細菌学会・中国・四国支部総会
    • Place of Presentation
      松山大学(愛媛県)
    • Year and Date
      2010-10-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Vibrio parahaemolyticus のチロシンキナーゼ VPA1604 は高分子量型莢膜多糖類(HMW-CPS)形成を調節する2010

    • Author(s)
      馬渡 一諭, 米田 由美, 本田 真奈美, 射場 仁美, 粟飯原 睦美
    • Organizer
      第63回日本細菌学会・中国・四国支部総会
    • Place of Presentation
      松山大学(愛媛県)
    • Year and Date
      2010-10-16
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://pub2.db.tokushima-u.ac.jp/ERD/person/60133/work-ja.html

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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