Analysis of new NLRP3 activation passway by Vibrio cholerae
| Project/Area Number |
22590396
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
NAKASONE Noboru 琉球大学, 大学院・医学研究科, 助教 (80175497)
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| Co-Investigator(Kenkyū-buntansha) |
小倉 裕範 琉球大学, 医学研究科, 助教 (60304557)
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Toshihiko 琉球大学, 大学院・医学研究科, 教授 (10292848)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 感染免疫 / 炎症反応 / コレラ菌 / ヘモリジン / NLRP3 / MyD88/Trif |
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| Research Abstract |
The purpose of this study is to isolate a MyD88/Trif independent NLRP3 activator from Vibrio cholerae O1 and clarified the signaling passway . We usedseveral factors of V.cholerae for the purpose, and we found that the hemolysin (HlyA) is most possible factor in V. cholerae. We also found that other bacterial hemolysins did not show same phenomenon. However, we could not obtain the certificate evidences.
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Report
(4 results)
Research Products
(17 results)
