Visualization of angiogenesis in a mouse for evaluation of anti-angiogenesis drugs

Research Project

Project/Area Number	22590501
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Applied pharmacology
Research Institution	Ehime University
Principal Investigator	INOUE Hirofumi 愛媛大学, 大学院・医学系研究科, 講師 (70321635)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000) Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords	イメージング / 血管新生 / 悪性腫瘍 / 血管内皮細胞 / VEGF / 発光イメージング / インビボイメージング / メッセンジャーRNA / 3'非翻訳領域
Research Abstract	We generated mice which expressed Cre in the endothelial cellsto visualize tumor angiogenesis. We found that the luciferase activity increased in the tumor-forming region. Moreover, the activity was observed in the metastatic region of the lung. These findings indicate that development of tumor angiogenesis can be visualized by using these mice.