| Project/Area Number |
22590503
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
UEDA Shinichiro 琉球大学, 大学院・医学研究科, 教授 (80285105)
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| Co-Investigator(Kenkyū-buntansha) |
URATA Hidenori 福岡大学, 筑紫病院, 教授 (30289524)
MATSUOKA Hidehiro 久留米大学, 医学部, 教授 (80248393)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | バイオマーカー / 遊離脂肪酸 / 血管内皮機能 / 白血球活性化 / 酸化ストレス / ミエロペルオキシダーゼ |
|---|
| Research Abstract |
We need more specific, relevant and predictive biomarkers for not only daily practice but also development of new drugs for the prevention of cardiovascular events. Our research project firstly revealed that not only endothelial function but also smooth muscle responses to NO were impaired in not only diabetic but also IGT patients. These impaired vascular functions were significantly associated with insulin sensitivity. We also showed that elevation of FFA significantly impaired endothelial function, rheological function of myocardial microcirculation, insulin sensitivity and enhanced leukocyte function and angiotensin II forming activity. RAS inhibitors as well as dihydropyridine calcium antagonists significantly but not completely prevented these effects of FFA. We clarified mechanisms for FFA induced endothelial function and insulin resistance and established experimental system for the assessment antiatherosclerotic drugs in human.
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